Compound
N,N-dimethylglycine
An amino acid zwitterion resulting from transfer of a proton from the carboxy to the amino group of N,N-dimethylglycine; major species at pH 7.3.
Definition from ChEBI (CHEBI:58251), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C4H9NO2
- Mass
- 103.121 g/mol
- Charge
- 0
- InChIKey
- FFDGPVCHZBVARC-UHFFFAOYSA-N
- SMILES
- C[NH+](C)CC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- SLC22A5ProteinUNIPROT:O76082transported byInferred only5 paths5 endpoints
- DMGDHProteinUNIPROT:Q9UI17substrate ofInferred only4 paths4 endpoints
- glycine betaineCompoundCHEBI:17750converted toInferred only2 paths2 endpoints
- glycineCompoundCHEBI:57305converted toInferred only1 path1 endpoint
- SLC36A2ProteinUNIPROT:Q495M3transported byInferred only1 path1 endpoint
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: N,N-dimethylglycine · Sources: Rhea
- glycine is converted to N,N-dimethylglycineCompoundRhea RHEA:32463Inferred only
- N,N-dimethylglycine is converted to glycineCompoundRhea RHEA:32463Inferred only
- glycine betaine is converted to N,N-dimethylglycineCompoundRhea RHEA:10072Inferred only
- N,N-dimethylglycine is converted to glycine betaineCompoundRhea RHEA:10072Inferred only
- N,N-dimethylglycine is converted to sarcosineCompoundRhea RHEA:15453Inferred only
- sarcosine is converted to N,N-dimethylglycineCompoundRhea RHEA:15453Inferred only
- N,N-dimethylglycine is a substrate of DMGDHProteinRhea RHEA:52856Inferred only
- N,N-dimethylglycine is transported by SLC22A15ProteinRhea RHEA:76271Inferred only
- N,N-dimethylglycine is transported by SLC22A5ProteinRhea RHEA:76591Inferred only
- N,N-dimethylglycine is transported by SLC36A2ProteinRhea RHEA:70659Inferred only
Reactions
13 reactions
N,N-dimethylglycine+S-adenosyl-L-methionineglycine betaine+S-adenosyl-L-homocysteine+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:10072CC BY 4.0Reference data
sarcosine+S-adenosyl-L-methionineN,N-dimethylglycine+S-adenosyl-L-homocysteine+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:15453CC BY 4.0Reference data
N,N-dimethylglycine+dioxygen+watersarcosine+formaldehyde+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:17077CC BY 4.0Reference data
L-homocysteine+glycine betaineN,N-dimethylglycine+L-methionine
Catalysed by BHMT
Reaction pageLeft to rightBalanced
Rhea RHEA:22336CC BY 4.0Reference data
glycine+2S-adenosyl-L-methionineN,N-dimethylglycine+2S-adenosyl-L-homocysteine+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:32463CC BY 4.0Reference data
glycine betaine+NADH(2-)+dioxygen+hydronN,N-dimethylglycine+formaldehyde+NAD(1-)+water
Reaction pageDirection not assertedBalanced
Rhea RHEA:45700CC BY 4.0Reference data
N,N-dimethylglycine+(6S)-5,6,7,8-tetrahydrofolate+dioxygensarcosine+(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate+hydrogen peroxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:45756CC BY 4.0Reference data
(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n)+N,N-dimethylglycine+oxidized [electron-transfer flavoprotein]+hydron(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n)+sarcosine+reduced [electron-transfer flavoprotein]
Catalysed by DMGDH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52856CC BY 4.0Reference data
Co(I)-[glycine betaine-specific corrinoid protein]+glycine betaine+hydronmethyl-Co(III)-[glycine betaine-specific corrinoid protein]+N,N-dimethylglycine
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:65996CC BY 4.0Reference data
N,N-dimethylglycine+hydronN,N-dimethylglycine+hydron
Transported by SLC36A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:70659CC BY 4.0Reference data
oxidized 2[4Fe-4S]-[ferredoxin]+N,N-dimethylglycine+waterreduced 2[4Fe-4S]-[ferredoxin]+sarcosine+formaldehyde+2hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:74167CC BY 4.0Reference data
N,N-dimethylglycineN,N-dimethylglycine
Transported by SLC22A15
Reaction pageRight to leftBalanced
Rhea RHEA:76271CC BY 4.0Reference data
On the label
Labelled products
23 products
Source: NIH DSLD · Ingredient: N,N-dimethylglycine · 23 products · Declared amount per serving: 125–500 mg (23 products)
23 labels state an amount0 do not
- BodSmithDMG 300 Liquid300 mgper 1 Milliliter(s)DSLD:252236
- DaVinci Benefits LineAcute Immune Benefits450 mgper 1 mLDSLD:303567
- DaVinci Benefits LineAcute Immune Benefits Liquid450 mgper 1 mLDSLD:303568
- DaVinci Benefits LineMaitake-DMG Liquid450 mgper 1 mLDSLD:313202
- DaVinci LaboratoriesBehavior Balance-DMG Liquid250 mgper 5 mLDSLD:303722
- DaVinci LaboratoriesGluconic DMG 250 mg250 mgper 1 Tablet(s)DSLD:287871
- DaVinci LaboratoriesGluconic DMG 250 mg250 mgper 1 Tablet(s)DSLD:291612
- DaVinci LaboratoriesGluconic DMG 250 mg250 mgper 1 Tablet(s)DSLD:303953
- DaVinci LaboratoriesGluconic DMG 250 mg250 mgper 1 Tablet(s)DSLD:305231
- DaVinci LaboratoriesGluconic DMG 250 mg250 mgper 1 Tablet(s)DSLD:322168
- DaVinci LaboratoriesGluconic DMG 250 mg250 mgper 1 Tablet(s)DSLD:322169
- DaVinci LaboratoriesGluconic DMG 500 mg500 mgper 1 Tablet(s)DSLD:303954
Show the remaining 11
- DaVinci LaboratoriesGluconic DMG 500 mg500 mgper 1 Tablet(s)DSLD:322170
- DaVinci LaboratoriesGluconic DMG Liquid 300 mgeach drop equals 15 mg DMG300 mgper 0.5 mLDSLD:288275
- DaVinci LaboratoriesGluconic DMG Liquid 300 mgeach drop equals 15 mg DMG300 mgper 0.5 mLDSLD:303955
- DaVinci Laboratories of VermontGluconic DMG 500 mg500 mgper 1 Tablet(s)DSLD:245243
- DaVinci Laboratories Of VermontGluconic DMG Liquid 300 mgN,N-Dimethylglycine Note: each drop equals 15 mg DMG300 mgper 1 mLDSLD:22729
- Douglas LaboratoriesDMG-125125 mgper 1 Tablet(s)DSLD:8654
- Dr. Seth's Vitamin VibrationsPower DMG Liquideach drop equals 15 mg DMG300 mgper 0.5 mLDSLD:315792
- FoodScience of VermontDMG Chewables 250 mg250 mgper 1 Chewable Tablet(s)DSLD:74959
- FoodScience of VermontLiquid DMG 300 mg300 mgper 1 mLDSLD:74987
- FoodScience of VermontPure-DMG 125 mg125 mgper 1 Tablet(s)DSLD:74937
- Genestra BrandsAmino DMG400 mgper 1 Capsule(s)DSLD:55500
Label record: NIH Office of Dietary Supplements · CC0
Where it reaches
3 systems, 3 regions, 3 tissues, 3 transporter routes — routes, not measurements: transporters known to carry N,N-dimethylglycine are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: N,N-dimethylglycine
- Also called
- (dimethylammonio)acetate
- Systematic name
- (dimethylazaniumyl)acetate