Compound
dUTP
A 2'-deoxyribonucleoside 5'-triphosphate(4−) resulting from deprotonation of the triphosphate OH groups of 2'-deoxyuridine-5'-triphosphate (dUTP); major species at pH 7.3.
Definition from ChEBI (CHEBI:61555), read 2026-09-23. CC BY 4.0.
Structure
No depiction stored
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- Class
- Organic compound, anion
- Formula
- C9H11N2O14P3
- Mass
- 464.109 g/mol
- Charge
- -4
- InChIKey
- AHCYMLUZIRLXAA-SHYZEUOFSA-J
- SMILES
- O=c1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O2)c(=O)n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
16 entities
16 entities reached.
0 reported hops16 assembled from the scaffold
- SLC25A36ProteinUNIPROT:Q96CQ1transported byInferred only78 paths39 endpoints
- NME1ProteinUNIPROT:P15531substrate ofInferred only64 paths32 endpoints
- NME2ProteinUNIPROT:P22392substrate ofInferred only52 paths26 endpoints
- TXNProteinUNIPROT:P10599substrate ofInferred only48 paths48 endpoints
- DUTProteinUNIPROT:P33316substrate ofInferred only33 paths11 endpoints
- RRM2ProteinUNIPROT:P31350substrate ofInferred only20 paths20 endpoints
- TXN2ProteinUNIPROT:Q99757substrate ofInferred only12 paths12 endpoints
- UCK2ProteinUNIPROT:Q9BZX2substrate ofInferred only12 paths6 endpoints
- UCKL1ProteinUNIPROT:Q9NWZ5substrate ofInferred only12 paths6 endpoints
- RRM1ProteinUNIPROT:P23921substrate ofInferred only12 paths12 endpoints
- NME7ProteinUNIPROT:Q9Y5B8substrate ofInferred only10 paths10 endpoints
- NME4ProteinUNIPROT:O00746substrate ofInferred only10 paths10 endpoints
What the reference databases state
Statements
36 statements
36 statements · 2 reference databases · Subject: dUTP · Sources: Human-GEM, Rhea
- dCTP is converted to dUTPCompoundHuman-GEM MAR04672Inferred only
- dCTP is converted to dUTPCompoundRhea RHEA:22680Inferred only
- dUMP is converted to dUTPCompoundRhea RHEA:64964Inferred only
- dUTP is converted to dUMPCompoundHuman-GEM MAR08483Inferred only
- dUTP is converted to dUMPCompoundHuman-GEM MAR11398Inferred only
- dUTP is converted to dUMPCompoundRhea RHEA:10248Inferred only
- dUTP is converted to dUMPCompoundRhea RHEA:64964Inferred only
- dUTP is converted to dUMPCompoundHuman-GEM MAR04643Inferred only
- dUMP is converted to dUTPCompoundRhea RHEA:10248Inferred only
- formate is converted to dUTPCompoundRhea RHEA:51628Inferred only
- dUTP is converted to formateCompoundRhea RHEA:51628Inferred only
- dUTP is a substrate of DUTProteinRhea RHEA:10248Inferred only
Show the remaining 24
- dUTP is a substrate of DUTProteinHuman-GEM MAR04643Inferred only
- dUTP is a substrate of DUTProteinHuman-GEM MAR08483Inferred only
- dUTP is a substrate of NME1ProteinHuman-GEM MAR07889Inferred only
- dUTP is a substrate of NME1ProteinHuman-GEM MAR04673Inferred only
- dUTP is a substrate of NME2ProteinHuman-GEM MAR07889Inferred only
- dUTP is a substrate of NME2ProteinHuman-GEM MAR04673Inferred only
- dUTP is a substrate of NME3ProteinHuman-GEM MAR04673Inferred only
- dUTP is a substrate of NME4ProteinHuman-GEM MAR04673Inferred only
- dUTP is a substrate of NME6ProteinHuman-GEM MAR04673Inferred only
- dUTP is a substrate of NME7ProteinHuman-GEM MAR04673Inferred only
- dUTP is a substrate of RRM1ProteinHuman-GEM MAR06621Inferred only
- dUTP is a substrate of RRM2ProteinHuman-GEM MAR06621Inferred only
- dUTP is a substrate of RRM2BProteinHuman-GEM MAR06621Inferred only
- dUTP is a substrate of TXNProteinHuman-GEM MAR06621Inferred only
- dUTP is a substrate of TXN2ProteinHuman-GEM MAR06621Inferred only
- dUTP is a substrate of UCK1ProteinHuman-GEM MAR05352Inferred only
- dUTP is a substrate of UCK2ProteinHuman-GEM MAR04676Inferred only
- dUTP is a substrate of UCK2ProteinHuman-GEM MAR05352Inferred only
- dUTP is a substrate of UCKL1ProteinHuman-GEM MAR05352Inferred only
- dUTP is a substrate of UCKL1ProteinHuman-GEM MAR04676Inferred only
- dUTP is transported by SLC25A33ProteinHuman-GEM MAR20163Inferred only
- dUTP is transported by SLC25A33ProteinRhea RHEA:73519Inferred only
- dUTP is transported by SLC25A36ProteinHuman-GEM MAR20149Inferred only
- dUTP is transported by SLC25A36ProteinRhea RHEA:73591Inferred only
Reactions
23 reactions
thioredoxin dithiol+UTPdUTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04618CC BY 4.0Reference data
dUTP+waterdUMP+proton+diphosphate(3-)
Catalysed by DUT
Reaction pageLeft to rightBalancedEC 3.6.1.23, 3.6.1.9mitochondrial matrix
Human-GEM MAR04643CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 3.5.4.13cytosol
Human-GEM MAR04672CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04673CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04675CC BY 4.0Reference data
cytidine+dUTPcytidine 5'-monophosphate+MAM01754c+proton
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR04676CC BY 4.0Reference data
dUTP+uridineMAM01754c+proton+UMP
Catalysed by UCK1 or UCK2 or UCKL1
Reaction pageLeft to rightBalancedEC 2.7.1.48cytosol
Human-GEM MAR05352CC BY 4.0Reference data
dUTP+water+thioredoxin disulfidethioredoxin dithiol+UTP
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageReversibleBalancedEC 1.17.4.1mitochondrial matrix
Human-GEM MAR06621CC BY 4.0Reference data
thioredoxin dithiol+UTPdUTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1nucleus
Human-GEM MAR06622CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 2.7.4.6nucleus
Human-GEM MAR07889CC BY 4.0Reference data
dUTP+waterdUMP+proton+diphosphate(3-)
Catalysed by DUT
Reaction pageLeft to rightBalancedEC 3.6.1.23nucleus
Human-GEM MAR08483CC BY 4.0Reference data
dUTP+waterdUMP+proton+diphosphate(3-)
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR11398CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 39 tissues, 39 transporter routes — routes, not measurements: transporters known to carry dUTP are expressed there, and no source reports it arriving.
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Other names
10 names
Resolves to: dUTP
- Also called
- 2'-deoxyuridine-5'-triphosphate2'-deoxyuridine-5'-triphosphate tetraanion2'-deoxyuridine-5'-triphosphate(4-)2'-deoxyuridine-5'-triphosphate(4−)deoxy-UTP(4-)deoxy-UTP(4−)deoxyuridine-triphosphate(4-)deoxyuridine-triphosphate(4−)dUTP tetraanion
- Systematic name
- 2'-deoxy-5'-O-({[(phosphonatooxy)phosphinato]oxy}phosphinato)uridine