Compound
natamycin
Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically.
Studied for
2 endpoints, 2 findings, from 2 papers.
Structure
- Class
- Organic compound
- Formula
- C33H47NO13
- Mass
- 665.733 g/mol
- Charge
- 0
- InChIKey
- NCXMLFZGDNKEPB-FFPOYIOWSA-N
- SMILES
- [H][C@@]12C[C@H](O)C[C@]3(O)C[C@H](O)[C@@H](C(=O)O)[C@]([H])(C[C@@H](O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O)/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]1O2)O3
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What the evidence says
How to read these marks2 findings across 2 endpoints, from 2 papers, strongest first.
What moved
2 findings
Inhibits CAT
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Furthermore, natamycin can cause oxidative damage to the fungus, as evidenced by decreased superoxide dismutase and catalase enzyme activity.”
Quoted verbatim from Natamycin Has an Inhibitory Effect on Neofusicoccum parvum, the Pathogen of Chestnuts.. - Study
- in vitro · not in humans
- Population
- Neofusicoccum parvum, fungal culture
Natamycin Has an Inhibitory Effect on Neofusicoccum parvum, the Pathogen of Chestnuts.2023PMID:37175119
Depletes oxalic acid
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Natamycin markedly disrupted hyphal form, sclerotia formation, integrity of the cell membrane, and reduced the content of oxalic acid and ergosterol, whereas it increased the reactive oxygen species (ROS) and malondialdehyde content.”
Quoted verbatim from Efficacy and toxic action of the natural product natamycin against Sclerotinia sclerotiorum.. - Study
- in vitro · not in humans
- Population
- Sclerotinia sclerotiorum, mycelial culture
Efficacy and toxic action of the natural product natamycin against Sclerotinia sclerotiorum.2024PMID:38087429
Registered, and not reported
Trials on ClinicalTrials.gov that list natamycin as an intervention, reached completed, terminated or suspended, and posted no results. What they found is not known, and that is the point.
Trials without posted results
3 trials
3 registered trials without posted results. 3 passed an actual primary completion date more than a year ago, which is the reporting window FDAAA 801 sets.
3 past the window0 within it, or no actual date
- NCT06411314completed2023-07-26industrypast the reporting window
- NCT05655689completed2023-01-01a university or hospitalpast the reporting window
- NCT00516399terminated— The DSMC decided it appeared futile to attempt to demonstrate non-inferiority of povidone-iodine to Natamycin.2010-09a university or hospitalpast the reporting window
Papers screened
26 papers
26 papers screened for natamycin. 2 produced a finding, 10 were read and discarded, 14 have not been read yet. Each group opens to the papers in it.
The whole record lists every paper, the query that retrieved it and the date it was decided.
Produced a finding2 papers
- PMID:371751192026-09-18
- PMID:380874292026-09-18
Discarded: an endpoint this vocabulary does not hold9 papers
- PMID:31010869no claim extracted — no_outcome_node — measured: in vitro checkerboard synergy (MIC) of natamycin combined with nonantifungal ophthalmic agents against natamycin-resistant Fusarium ocular isolates | antifungal combination synergy testing (checkerboard MIC), Fusarium ocular isolates2026-09-18
- PMID:32891143no claim extracted — no_outcome_node — measured: in vitro checkerboard synergy (MIC) of natamycin combined with chlorhexidine against clinical Fusarium strains | antifungal combination synergy testing (checkerboard MIC), Fusarium isolates2026-09-18
- PMID:36249301no claim extracted — no_outcome_node — measured: minimum cysticidal concentration (MCC) of natamycin against Acanthamoeba cysts, in vitro assay | Acanthamoeba cysticidal potency, minimum cysticidal concentration (MCC) assay2026-09-18
- PMID:38117668no claim extracted — no_outcome_node — measured: transcorneal permeability of natamycin from an ophthalmic suspension across excised cornea, ex vivo permeation study | ocular transcorneal drug permeability / flux, ex vivo permeation assay2026-09-18
- PMID:38569998no claim extracted — no_outcome_node — measured: antifungal/antibacterial inhibition zone and antioxidant activity of natamycin-ferulic acid loaded PEG/CMC films against Aspergillus niger, E. coli and C. botulinum | food-packaging antimicrobial film performance metrics (moisture content, puncture force) on cheese during storage2026-09-18
- PMID:38806103claims extracted but the object named resolved to no node — recorded in candidate_nodes (ADR-0070)2026-09-18
- PMID:40372083no claim extracted — no_outcome_node — measured: in vitro antifungal susceptibility (MIC) of clinical Fusarium isolates to natamycin, EUCAST broth microdilution | antifungal susceptibility / MIC against Fusarium species, EUCAST broth microdilution2026-09-18
- PMID:40451348no claim extracted — no_outcome_node — measured: decay rate and fungal community diversity of jujube fruit surface treated with pectin-natamycin coating, high-throughput amplicon sequencing | postharvest fruit decay/spoilage rate and fungal microbiome diversity2026-09-18
- PMID:42493047claims extracted but the object named resolved to no node — recorded in candidate_nodes (ADR-0070)2026-09-18
Discarded: no extractable result1 paper
- PMID:37289410no claim extracted — narrated_not_pooled2026-09-18
Not read yet14 papers
- PMID:240014392026-09-01
- PMID:252263052026-09-01
- PMID:275890202026-09-01
- PMID:278742242026-09-01
- PMID:305623372026-09-01
- PMID:318200712026-09-01
- PMID:352552442026-09-01
- PMID:355044172026-09-01
- PMID:356880982026-09-01
- PMID:359145702026-09-01
- PMID:365633122026-09-01
- PMID:375799122026-09-01
and 2 more.
Sources cited
2 papers
The 2 findings about natamycin on this page come from 2 papers, newest first. The count beside each opens the first finding drawn from it.
Other names
22 names
Every name this graph resolves to natamycin. Searching any of them lands here.
- Also called
- antibiotic A-5283CL 12,625CL 12625E 235E-235pimaricinpimaricinetennecetin
- Systematic name
- (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.0(5,7)]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(3-amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
- Sold as
- DelvocidDelvolanDelvoposMycophytMyprozineMyuprozineNatacynNatajenNatamatrixNatamaxPimafucinSynogil