Compound
prostaglandin E3
A prostaglandin carboxylic acid anion that is the conjugate base of prostaglandin E3, obtained by deprotonation of the carboxy group; major species at pH 7.3.
Definition from ChEBI (CHEBI:133132), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C20H29O5
- Mass
- 349.447 g/mol
- Charge
- -1
- InChIKey
- CBOMORHDRONZRN-QLOYDKTKSA-M
- SMILES
- CC/C=CC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=CCCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- PTGES3ProteinUNIPROT:Q15185substrate ofInferred only62 paths31 endpoints
- SLCO2A1ProteinUNIPROT:Q92959transported byInferred only28 paths13 endpoints
- PTGESProteinUNIPROT:O14684substrate ofInferred only26 paths13 endpoints
- PTGES2ProteinUNIPROT:Q9H7Z7substrate ofInferred only22 paths11 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only9 paths2 endpoints
What the reference databases state
Statements
13 statements
13 statements · 2 reference databases · Subject: prostaglandin E3 · Sources: Human-GEM, Rhea
- prostaglandin E3 is converted to prostaglandin H3CompoundRhea RHEA:50452Inferred only
- prostaglandin H3 is converted to prostaglandin E3CompoundRhea RHEA:50452Inferred only
- prostaglandin E3 is a substrate of PTGESProteinHuman-GEM MAR02584Inferred only
- prostaglandin E3 is a substrate of PTGESProteinHuman-GEM MAR02583Inferred only
- prostaglandin E3 is a substrate of PTGES2ProteinHuman-GEM MAR02584Inferred only
- prostaglandin E3 is a substrate of PTGES2ProteinHuman-GEM MAR02583Inferred only
- prostaglandin E3 is a substrate of PTGES3ProteinHuman-GEM MAR02583Inferred only
- prostaglandin E3 is a substrate of PTGES3ProteinHuman-GEM MAR02584Inferred only
- prostaglandin E3 is transported by SLCO1B1ProteinHuman-GEM MAR06194Inferred only
- prostaglandin E3 is transported by SLCO1B1ProteinHuman-GEM MAR06193Inferred only
- prostaglandin E3 is transported by SLCO1B1ProteinHuman-GEM MAR06195Inferred only
- prostaglandin E3 is transported by SLCO2A1ProteinHuman-GEM MAR06234Inferred only
Show the remaining 1
- prostaglandin E3 is transported by SLCO2A1ProteinRhea RHEA:74351Inferred only
Reactions
13 reactions
11R-hydroperoxy-(5Z,8Z,12E,14Z)-eicosatetraenoate+15-oxoprostaglandin E1+MAM00014x+(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate+MAM00254c+MAM00254m+MAM00254x+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00274c+MAM00274r+MAM00276c+MAM00277c+MAM00278c+MAM00280c+MAM00282c+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+11beta-hydroxyandrost-4-ene-3,17-dione+MAM00293c+MAM00297c+MAM00298c+MAM00304c+MAM00306c+MAM00308c+MAM00318c+MAM00318r+MAM00319c+MAM00320c+MAM00321c+MAM00322c+MAM00323c+MAM00323r+MAM00324r+MAM00327c+MAM00327r+MAM00328c+MAM00328r+MAM00333r+12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate+(13S)-hydroxy-(9Z,11E)-octadecadienoate+MAM00338c+MAM00340c+MAM00352r+13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00364c+14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate+MAM00378c+MAM00382c+15-deoxy-Delta(12,14)-prostaglandin J2+MAM00384c+MAM00386c+MAM00386r+MAM00386x+MAM00387c+MAM00387r+MAM00387x+MAM00388c+MAM00388r+MAM00388x+MAM00389c+MAM00389r+MAM00389x+15-oxoprostaglandin F2alpha+MAM00395c+16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00398x+17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00424m+MAM00425x+MAM00426c+18-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM00430c+MAM00590c+MAM00595c+MAM00595r+MAM00598c+MAM00598r+MAM00602c+MAM00687m+MAM00687x+MAM01038n+MAM01039x+MAM01041n+MAM01046c+MAM01047c+MAM01049c+MAM01050c+MAM01051c+5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+MAM01055c+MAM01120c+MAM01120r+MAM01122c+MAM01122r+MAM01150c+MAM01150m+MAM01150x+MAM01153c+MAM01153m+MAM01153r+MAM01153x+MAM01167c+MAM01168r+MAM01171c+MAM01171m+MAM01171x+MAM01172c+MAM01172m+MAM01172x+7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+MAM01202c+MAM01208c+8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+MAM01210c+MAM01213c+MAM01239c+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate+MAM02368c+MAM02395n+MAM02395r+MAM02395x+MAM02396r+MAM02396x+malonaldehyde+MAM02538c+MAM02538n+MAM02649m+MAM02649x+prostaglandin E2+prostaglandin E3+prostaglandin H1+prostaglandin J2+MAM02797c+MAM02798c+MAM02799c+MAM02851c+MAM02852c+MAM02862c+MAM02863c+MAM02864c+MAM03055c+MAM03055r+MAM03055x+MAM03056cMAM10003e
Reaction pageLeft to rightBalance undeterminablecytosol, peroxisome, mitochondrial matrix, endoplasmic reticulum, nucleus, extracellular space
Human-GEM MAR00036CC BY 4.0Reference data
MAM02716cprostaglandin E3
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
Human-GEM MAR02583CC BY 4.0Reference data
MAM02716nprostaglandin E3
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3nucleus
Human-GEM MAR02584CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR04230CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin E3MAM01980e+hydrogencarbonate+prostaglandin E3
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminablecytosol, extracellular space
Human-GEM MAR06193CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E3+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+prostaglandin E3+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06194CC BY 4.0Reference data
hydrogencarbonate+prostaglandin E3+MAM02901chydrogencarbonate+prostaglandin E3+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06195CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+prostaglandin E3CHEBI:16856+hydrogencarbonate+prostaglandin E3
Transported by SLCO2A1
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06234CC BY 4.0Reference data
prostaglandin E3prostaglandin E3
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06269CC BY 4.0Reference data
(S)-lactic acid+prostaglandin E3(S)-lactic acid+prostaglandin E3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR10138CC BY 4.0Reference data
prostaglandin E3prostaglandin E3
Reaction pageReversibleBalancednucleus, cytosol
Human-GEM MAR10139CC BY 4.0Reference data
prostaglandin H3prostaglandin E3
Reaction pageDirection not assertedBalanced
Rhea RHEA:50452CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry prostaglandin E3 are expressed there, and no source reports it arriving.
Loading the model…
Other names
2 names
Resolves to: prostaglandin E3
- Systematic name
- (5Z,13E,15S,17Z)-11alpha,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oate(5Z,13E,15S,17Z)-11α,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oate