Endpoint
Estimated glomerular filtration rate
CAT:outcome/egfrreported in mL/min/1.73m21 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| creatine | down | 1 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
Reported to move it
1 finding
creatine — decreases
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Specifically, there was an increase in serum creatinine (mean difference 12.63 μmol/L, 95% CI 1.14 to 24.12) and decrease in eGFR (−25.79 mL/min/1.73 m2, 95% CI −44.3 to −7.25) in individuals on creatine supplementation compared to placebo.”
Quoted verbatim from Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double-blind placebo-controlled crossover trial.. - Study
- crossover
- Duration
- 3 months
- Dose
- creatine monohydrate ~100 mg/kg/day (2.5-10 g daily by weight band) for 12 weeks per crossover period
- Population
- children aged 5-18 years with facioscapulohumeral muscular dystrophy; safety outcome, not the primary endpoint; eGFR by the modified Schwartz creatinine-based equation
Effect -25.79 mean difference, 95% CI -44.3 to -7.25
Effect of creatine monohydrate on motor function in children with facioscapulohumeral muscular dystrophy: A multicenter, randomized, double-blind placebo-controlled crossover trial.2025PMID:40366059Permalink
How it is measured
eGFR from a stated estimating equation. The equation is recorded with each finding, and creatinine-based equations are flagged as such.
Measured, not recorded
- Subject
- estimated glomerular filtration rate
- Measurements
- 4 measurements
- Recorded as a finding
- No
Show what was measured
Estimated glomerular filtration rate
no effect, p = 0.5, n = 13
eGFR (mL/min/1.73 m2) | 80±13 | 81±11 | 81±10 | 81±10 | 0.5 | 0.6
PMID:25412338 · one of two readings recorded this
estimated glomerular filtration rate
no effect
However, a randomized, double-blind placebo-controlled clinical trial in patients with nondiabetic or diabetic proteinuric CKD has shown no significant effect of curcumin on proteinuria, estimated glomerular filtration rate, or lipid profile
PMID:35053230 · one of two readings recorded this
estimated glomerular filtration rate
no effect
The estimated glomerular filtration rate did not differ between the study groups in the entire postoperative period
PMID:35643076 · one of two readings recorded this
Estimated glomerular filtration rate
increases, n = 848
The pooled results showed that the FOSM product group was superior to the routine group in increasing eGFR (MD = 4.10 mL/min-1.73 m2, 95% CI 2.24–5.96, I2 = 74.8%, eight trials, 848 participants)
PMID:38189088 · one of two readings recorded this
Sources cited
1 paper
- Subject
- estimated glomerular filtration rate
- Findings
- 1
- Papers
- 1