Compound
prostaglandin I2
A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (hypertension, pulmonary).
Structure
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- Class
- Organic compound, anion
- Formula
- C20H31O5
- Mass
- 351.463 g/mol
- Charge
- -1
- InChIKey
- KAQKFAOMNZTLHT-OZUDYXHBSA-M
- SMILES
- [H][C@]12C[C@@H](O)[C@H](/C=C/[C@@H](O)CCCCC)[C@@]1([H])C/C(=C/CCCC(=O)[O-])O2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
11 statements
11 statements · 2 reference databases · Subject: prostaglandin I2 · Sources: Human-GEM, Rhea
- prostaglandin I2 is converted to 15-oxoprostaglandin F2alphaCompoundHuman-GEM MAR10395Inferred only
- 15-oxoprostaglandin F2alpha is converted to prostaglandin I2CompoundHuman-GEM MAR10395Inferred only
- prostaglandin I2 is converted to prostaglandin H2CompoundRhea RHEA:23580Inferred only
- prostaglandin H2 is converted to prostaglandin I2CompoundRhea RHEA:23580Inferred only
- prostaglandin H2 is converted to prostaglandin I2CompoundHuman-GEM MAR01308Inferred only
- prostaglandin I2 is a substrate of PTGISProteinRhea RHEA:23580Inferred only
- prostaglandin I2 is transported by SLC22A10ProteinHuman-GEM MAR06274Inferred only
- prostaglandin I2 is transported by SLCO1B1ProteinHuman-GEM MAR06211Inferred only
- prostaglandin I2 is transported by SLCO1B1ProteinHuman-GEM MAR06212Inferred only
- prostaglandin I2 is transported by SLCO1B1ProteinHuman-GEM MAR06213Inferred only
- prostaglandin I2 is transported by SLCO2A1ProteinHuman-GEM MAR06240Inferred only
Reactions
15 reactions
prostaglandin H2prostaglandin I2
Catalysed by PTGIS
Reaction pageLeft to rightBalancedEC 5.3.99.4GO:0005783
Human-GEM MAR01308CC BY 4.0Reference data
prostaglandin I2prostaglandin I2
Reaction pageReversibleBalancedGO:0005829, GO:0005783
Human-GEM MAR01309CC BY 4.0Reference data
MAM01168rwater+prostaglandin I2
Reaction pageReversibleBalancedGO:0005783
Human-GEM MAR01310CC BY 4.0Reference data
MAM01168cwater+prostaglandin I2
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR01318CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableGO:0005615
Human-GEM MAR04094CC BY 4.0Reference data
MAM01980c+hydrogencarbonate+prostaglandin I2MAM01980e+hydrogencarbonate+prostaglandin I2
Transported by SLCO1B1
Reaction pageReversibleBalance undeterminableGO:0005829, GO:0005615
Human-GEM MAR06211CC BY 4.0Reference data
hydrogencarbonate+prostaglandin I2+2,4-dinitrophenyl-S-glutathionehydrogencarbonate+prostaglandin I2+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06212CC BY 4.0Reference data
hydrogencarbonate+prostaglandin I2+MAM02901chydrogencarbonate+prostaglandin I2+MAM02901e
Transported by SLCO1B1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06213CC BY 4.0Reference data
CHEBI:16856+hydrogencarbonate+prostaglandin I2CHEBI:16856+hydrogencarbonate+prostaglandin I2
Transported by SLCO2A1
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06240CC BY 4.0Reference data
prostaglandin I2prostaglandin I2
Transported by SLC22A10
Reaction pageReversibleBalancedGO:0005829, GO:0005615
Human-GEM MAR06274CC BY 4.0Reference data
hydrogencarbonate+prostaglandin I2hydrogencarbonate+prostaglandin I2
Reaction pageLeft to rightBalancedGO:0005829, GO:0005615
Human-GEM MAR08937CC BY 4.0Reference data
prostaglandin I215-oxoprostaglandin F2alpha
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR10395CC BY 4.0Reference data
Where it reaches
5 systems, 8 regions, 15 tissues, 15 transporter routes — routes, not measurements: transporters known to carry prostaglandin I2 are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: prostaglandin I2
- Also called
- PGI2prostaglandin I2 anion
- Systematic name
- (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate(5Z,13E,15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dienoate