Compound
N-acetyl-L-aspartate
A doubly-charged N-acyl-L-α-amino acid anion resulting from deprotonation of both carboxy groups of N-acetyl-L-aspartic acid.
Definition from ChEBI (CHEBI:16953), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C6H7NO5
- Mass
- 173.124 g/mol
- Charge
- -2
- InChIKey
- OTCCIMWXFLJLIA-BYPYZUCNSA-L
- SMILES
- CC(=O)N[C@@H](CC(=O)[O-])C(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- ABCC5ProteinUNIPROT:O15440transported byInferred only11 paths11 endpoints
- ASPAProteinUNIPROT:P45381substrate ofInferred only8 paths4 endpoints
- RIMKLAProteinUNIPROT:Q8IXN7substrate ofInferred only6 paths3 endpoints
- SLC13A3ProteinUNIPROT:Q8WWT9transported byInferred only3 paths3 endpoints
- ACY3ProteinUNIPROT:Q96HD9substrate ofInferred only3 paths3 endpoints
- RIMKLBProteinUNIPROT:Q9ULI2substrate ofInferred only3 paths3 endpoints
What the reference databases state
Statements
15 statements
15 statements · 2 reference databases · Subject: N-acetyl-L-aspartate · Sources: Human-GEM, Rhea
- L-aspartate is converted to N-acetyl-L-aspartateCompoundRhea RHEA:14165Inferred only
- N-acetyl-L-aspartate is converted to N-acetyl-L-aspartyl-L-glutamateCompoundRhea RHEA:40035Inferred only
- N-acetyl-L-aspartyl-L-glutamate is converted to N-acetyl-L-aspartateCompoundRhea RHEA:40035Inferred only
- N-acetyl-L-aspartyl-L-glutamate is converted to N-acetyl-L-aspartateCompoundRhea RHEA:68356Inferred only
- N-acetyl-L-aspartate is converted to N-acetyl-L-aspartyl-L-glutamateCompoundRhea RHEA:68356Inferred only
- N-acetyl-L-aspartyl-L-glutamyl-L-glutamate is converted to N-acetyl-L-aspartateCompoundRhea RHEA:40039Inferred only
- N-acetyl-L-aspartate is converted to N-acetyl-L-aspartyl-L-glutamyl-L-glutamateCompoundRhea RHEA:40039Inferred only
- N-acetyl-L-aspartate is a substrate of ACY3ProteinHuman-GEM MAR08628Inferred only
- N-acetyl-L-aspartate is a substrate of ASPAProteinHuman-GEM MAR08628Inferred only
- N-acetyl-L-aspartate is a substrate of ASPAProteinRhea RHEA:59408Inferred only
- N-acetyl-L-aspartate is a substrate of RIMKLAProteinRhea RHEA:40039Inferred only
- N-acetyl-L-aspartate is a substrate of RIMKLAProteinRhea RHEA:40035Inferred only
Show the remaining 3
- N-acetyl-L-aspartate is a substrate of RIMKLBProteinRhea RHEA:40035Inferred only
- N-acetyl-L-aspartate is transported by ABCC5ProteinRhea RHEA:66744Inferred only
- N-acetyl-L-aspartate is transported by SLC13A3ProteinRhea RHEA:71947Inferred only
Reactions
12 reactions
CHEBI:15351+L-aspartateCHEBI:1146900+proton+N-acetyl-L-aspartate
Catalysed by NAT8L
Reaction pageLeft to rightBalancedEC 2.3.1.17mitochondrial matrix
Human-GEM MAR08626CC BY 4.0Reference data
N-acetyl-L-aspartateN-acetyl-L-aspartate
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol
Human-GEM MAR08627CC BY 4.0Reference data
water+N-acetyl-L-aspartateacetate+L-aspartate
Reaction pageLeft to rightBalancedEC 3.5.1.15cytosol
Human-GEM MAR08628CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10264CC BY 4.0Reference data
3sodium(1+)+N-acetyl-L-aspartate3sodium(1+)+N-acetyl-L-aspartate
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR10390CC BY 4.0Reference data
L-aspartate+acetyl-CoAN-acetyl-L-aspartate+coenzyme A(4-)+hydron
Catalysed by NAT8L
Reaction pageLeft to rightBalanced
Rhea RHEA:14165CC BY 4.0Reference data
N-acetyl-L-aspartate+L-glutamate(1-)+ATP(4-)N-acetyl-L-aspartyl-L-glutamate+ADP(3-)+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:40035CC BY 4.0Reference data
N-acetyl-L-aspartate+2L-glutamate(1-)+2ATP(4-)N-acetyl-L-aspartyl-L-glutamyl-L-glutamate+2ADP(3-)+2hydrogenphosphate+2hydron
Catalysed by RIMKLA
Reaction pageDirection not assertedBalanced
Rhea RHEA:40039CC BY 4.0Reference data
N-acetyl-L-aspartate+waterL-aspartate+acetate
Catalysed by ASPA
Reaction pageLeft to rightBalanced
Rhea RHEA:59408CC BY 4.0Reference data
N-acetyl-L-aspartate+ATP(4-)+waterN-acetyl-L-aspartate+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC5
Reaction pageLeft to rightBalanced
Rhea RHEA:66744CC BY 4.0Reference data
N-acetyl-L-aspartyl-L-glutamate+waterN-acetyl-L-aspartate+L-glutamate(1-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:68356CC BY 4.0Reference data
N-acetyl-L-aspartate+3sodium(1+)N-acetyl-L-aspartate+3sodium(1+)
Transported by SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71947CC BY 4.0Reference data
Where it reaches
4 systems, 6 regions, 12 tissues, 12 transporter routes — routes, not measurements: transporters known to carry N-acetyl-L-aspartate are expressed there, and no source reports it arriving.
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Other names
2 names
Resolves to: N-acetyl-L-aspartate
- Also called
- (S)-2-(acetylamino)succinate
- Systematic name
- (2S)-2-acetamidobutanedioate