Compound
dCTP
A 2'-deoxyribonucleoside 5'-triphosphate(4−) arising from deprotonation of the triphosphate OH groups of 2'-deoxycytidine 5'-triphosphate (dCTP); major species at pH 7.3.
Definition from ChEBI (CHEBI:61481), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C9H12N3O13P3
- Mass
- 463.125 g/mol
- Charge
- -4
- InChIKey
- RGWHQCVHVJXOKC-SHYZEUOFSA-J
- SMILES
- Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O2)c(=O)n1
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
37 entities
37 entities reached.
0 reported hops37 assembled from the scaffold
- NME1ProteinUNIPROT:P15531substrate ofInferred only119 paths31 endpoints
- SLC25A36ProteinUNIPROT:Q96CQ1transported byInferred only78 paths39 endpoints
- NME2ProteinUNIPROT:P22392substrate ofInferred only78 paths26 endpoints
- RFC5ProteinUNIPROT:P40937substrate ofInferred only78 paths78 endpoints
- POLD2ProteinUNIPROT:P49005substrate ofInferred only62 paths62 endpoints
- POLD1ProteinUNIPROT:P28340substrate ofInferred only61 paths61 endpoints
- POLD3ProteinUNIPROT:Q15054substrate ofInferred only51 paths51 endpoints
- POLA1ProteinUNIPROT:P09884substrate ofInferred only45 paths45 endpoints
- POLEProteinUNIPROT:Q07864substrate ofInferred only43 paths43 endpoints
- POLD4ProteinUNIPROT:Q9HCU8substrate ofInferred only41 paths41 endpoints
- POLA2ProteinUNIPROT:Q14181substrate ofInferred only39 paths39 endpoints
- POLE2ProteinUNIPROT:P56282substrate ofInferred only37 paths37 endpoints
Show the remaining 25
- POLE3ProteinUNIPROT:Q9NRF9substrate ofInferred only32 paths32 endpoints
- POLE4ProteinUNIPROT:Q9NR33substrate ofInferred only30 paths30 endpoints
- NME4ProteinUNIPROT:O00746substrate ofInferred only30 paths10 endpoints
- POLBProteinUNIPROT:P06746substrate ofInferred only26 paths26 endpoints
- POLHProteinUNIPROT:Q9Y253substrate ofInferred only24 paths24 endpoints
- CMPK1ProteinUNIPROT:P30085substrate ofInferred only24 paths4 endpoints
- REV3LProteinUNIPROT:O60673substrate ofInferred only19 paths19 endpoints
- POLKProteinUNIPROT:Q9UBT6substrate ofInferred only18 paths18 endpoints
- NME3ProteinUNIPROT:Q13232substrate ofInferred only16 paths8 endpoints
- AK4ProteinUNIPROT:P27144substrate ofInferred only16 paths8 endpoints
- POLIProteinUNIPROT:Q9UNA4substrate ofInferred only15 paths15 endpoints
- REV1ProteinUNIPROT:Q9UBZ9substrate ofInferred only14 paths14 endpoints
- NME6ProteinUNIPROT:O75414substrate ofInferred only12 paths6 endpoints
- AK1ProteinUNIPROT:P00568substrate ofInferred only12 paths12 endpoints
- NME7ProteinUNIPROT:Q9Y5B8substrate ofInferred only10 paths10 endpoints
- AK9ProteinUNIPROT:Q5TCS8substrate ofInferred only9 paths3 endpoints
- SAMHD1ProteinUNIPROT:Q9Y3Z3substrate ofInferred only9 paths9 endpoints
- TENT4AProteinUNIPROT:Q5XG87substrate ofInferred only7 paths7 endpoints
- POLMProteinUNIPROT:Q9NP87substrate ofInferred only6 paths3 endpoints
- POLLProteinUNIPROT:Q9UGP5substrate ofInferred only5 paths5 endpoints
- POLG2ProteinUNIPROT:Q9UHN1substrate ofInferred only5 paths5 endpoints
- POLGProteinUNIPROT:P54098substrate ofInferred only5 paths5 endpoints
- DCTPP1ProteinUNIPROT:Q9H773substrate ofInferred only4 paths4 endpoints
- POLQProteinUNIPROT:O75417substrate ofInferred only4 paths4 endpoints
- POLNProteinUNIPROT:Q7Z5Q5substrate ofInferred only2 paths2 endpoints
What the reference databases state
Statements
89 statements
89 statements · 2 reference databases · Subject: dCTP · Sources: Human-GEM, Rhea
- dCDP is converted to dCTPCompoundRhea RHEA:79875Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR04670Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR07871Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR07872Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR07890Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR07891Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR08471Inferred only
- dCTP is converted to dCDPCompoundHuman-GEM MAR08472Inferred only
- dCTP is converted to dCDPCompoundRhea RHEA:27678Inferred only
- dCTP is converted to dCDPCompoundRhea RHEA:64948Inferred only
- dCTP is converted to dCDPCompoundRhea RHEA:79875Inferred only
- dCDP is converted to dCTPCompoundHuman-GEM MAR04670Inferred only
Show the remaining 77
- dCDP is converted to dCTPCompoundHuman-GEM MAR07871Inferred only
- dCDP is converted to dCTPCompoundHuman-GEM MAR07872Inferred only
- dCDP is converted to dCTPCompoundHuman-GEM MAR07890Inferred only
- dCDP is converted to dCTPCompoundHuman-GEM MAR07891Inferred only
- dCDP is converted to dCTPCompoundHuman-GEM MAR08471Inferred only
- dCDP is converted to dCTPCompoundHuman-GEM MAR08472Inferred only
- dCDP is converted to dCTPCompoundRhea RHEA:27678Inferred only
- dCDP is converted to dCTPCompoundRhea RHEA:64948Inferred only
- dCTP is converted to dCMPCompoundRhea RHEA:64944Inferred only
- dCTP is converted to dCMPCompoundRhea RHEA:22636Inferred only
- dCMP is converted to dCTPCompoundRhea RHEA:64944Inferred only
- dCMP is converted to dCTPCompoundRhea RHEA:22636Inferred only
- dUMP is converted to dCTPCompoundRhea RHEA:19205Inferred only
- dCTP is converted to dUMPCompoundRhea RHEA:19205Inferred only
- dCTP is converted to dUTPCompoundHuman-GEM MAR04672Inferred only
- dCTP is converted to dUTPCompoundRhea RHEA:22680Inferred only
- formate is converted to dCTPCompoundRhea RHEA:51620Inferred only
- dCTP is converted to formateCompoundRhea RHEA:51620Inferred only
- dCTP is a substrate of AK1ProteinRhea RHEA:79875Inferred only
- dCTP is a substrate of AK4ProteinRhea RHEA:79875Inferred only
- dCTP is a substrate of AK4ProteinRhea RHEA:27678Inferred only
- dCTP is a substrate of AK9ProteinRhea RHEA:27678Inferred only
- dCTP is a substrate of AK9ProteinRhea RHEA:79875Inferred only
- dCTP is a substrate of AK9ProteinHuman-GEM MAR07890Inferred only
- dCTP is a substrate of CDADC1ProteinRhea RHEA:22680Inferred only
- dCTP is a substrate of CMPK1ProteinHuman-GEM MAR07872Inferred only
- dCTP is a substrate of CMPK1ProteinHuman-GEM MAR08472Inferred only
- dCTP is a substrate of CMPK1ProteinHuman-GEM MAR08471Inferred only
- dCTP is a substrate of CMPK1ProteinHuman-GEM MAR08453Inferred only
- dCTP is a substrate of CMPK1ProteinHuman-GEM MAR08452Inferred only
- dCTP is a substrate of CMPK1ProteinHuman-GEM MAR07871Inferred only
- dCTP is a substrate of DCTPP1ProteinRhea RHEA:22636Inferred only
- dCTP is a substrate of NME1ProteinRhea RHEA:27678Inferred only
- dCTP is a substrate of NME1ProteinHuman-GEM MAR07890Inferred only
- dCTP is a substrate of NME1ProteinHuman-GEM MAR07891Inferred only
- dCTP is a substrate of NME1ProteinHuman-GEM MAR04670Inferred only
- dCTP is a substrate of NME2ProteinHuman-GEM MAR04670Inferred only
- dCTP is a substrate of NME2ProteinHuman-GEM MAR07891Inferred only
- dCTP is a substrate of NME2ProteinHuman-GEM MAR07890Inferred only
- dCTP is a substrate of NME3ProteinHuman-GEM MAR07890Inferred only
- dCTP is a substrate of NME3ProteinHuman-GEM MAR04670Inferred only
- dCTP is a substrate of NME4ProteinRhea RHEA:27678Inferred only
- dCTP is a substrate of NME4ProteinHuman-GEM MAR07890Inferred only
- dCTP is a substrate of NME4ProteinHuman-GEM MAR04670Inferred only
- dCTP is a substrate of NME6ProteinHuman-GEM MAR07890Inferred only
- dCTP is a substrate of NME6ProteinHuman-GEM MAR04670Inferred only
- dCTP is a substrate of NME7ProteinHuman-GEM MAR04670Inferred only
- dCTP is a substrate of POLA1ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLA2ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLBProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLD1ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLD2ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLD3ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLD4ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLEProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLE2ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLE3ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLE4ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLGProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLG2ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLHProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLIProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLKProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLLProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLMProteinRhea RHEA:86319Inferred only
- dCTP is a substrate of POLMProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLNProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of POLQProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of REV1ProteinRhea RHEA:86319Inferred only
- dCTP is a substrate of REV3LProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of RFC5ProteinHuman-GEM MAR07160Inferred only
- dCTP is a substrate of SAMHD1ProteinRhea RHEA:80083Inferred only
- dCTP is a substrate of TENT4AProteinHuman-GEM MAR07160Inferred only
- dCTP is transported by SLC25A33ProteinRhea RHEA:73539Inferred only
- dCTP is transported by SLC25A33ProteinHuman-GEM MAR20153Inferred only
- dCTP is transported by SLC25A36ProteinHuman-GEM MAR20134Inferred only
- dCTP is transported by SLC25A36ProteinRhea RHEA:73607Inferred only
Reactions
31 reactions
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
CHEBI:17677+thioredoxin dithioldCTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1cytosol
Human-GEM MAR04617CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04670CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 3.5.4.13cytosol
Human-GEM MAR04672CC BY 4.0Reference data
0.3CHEBI:16284+0.2dCTP+0.2CHEBI:16497+0.3dTTPMAM01721n+diphosphate(3-)
Catalysed by POLE4 & POLE3 or POLD1 & POLD2 & POLD3 & POLD4 or POLA1 & POLA2 or POLA1 & POLD1 & POLD2 & POLE2 & POLE & POLA2 & POLD3 & POLD4 & POLE4 & POLE3 or REV3L or POLQ or POLB or POLI or RFC5 or TENT4A or POLK or POLM and 5 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR07860CC BY 4.0Reference data
Catalysed by CMPK1
Reaction pageReversibleBalancedEC 2.7.4.14cytosol
Human-GEM MAR07871CC BY 4.0Reference data
Catalysed by CMPK1
Reaction pageReversibleBalancedEC 2.7.4.14nucleus
Human-GEM MAR07872CC BY 4.0Reference data
Catalysed by NME3 or NME4 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07890CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 2.7.4.6nucleus
Human-GEM MAR07891CC BY 4.0Reference data
Catalysed by CMPK1
Reaction pageReversibleBalancedEC 2.7.4.14cytosol
Human-GEM MAR08452CC BY 4.0Reference data
Catalysed by CMPK1
Reaction pageReversibleBalancedEC 2.7.4.14nucleus
Human-GEM MAR08453CC BY 4.0Reference data
Where it reaches
7 systems, 13 regions, 39 tissues, 39 transporter routes — routes, not measurements: transporters known to carry dCTP are expressed there, and no source reports it arriving.
Loading the model…
Other names
7 names
Resolves to: dCTP
- Also called
- 2'-deoxycytidine 5'-triphosphate2'-deoxycytidine 5'-triphosphate(4-)2'-deoxycytidine 5'-triphosphate(4−)dCTP tetraaniondeoxycytidine triphosphate(4-)deoxycytidine triphosphate(4−)
- Systematic name
- 2'-deoxy-5'-O-({[(phosphonatooxy)phosphinato]oxy}phosphinato)cytidine