Compound
indigo carmine
Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.
CHEBI:31695ChEBI
Studied for
1 endpoint, 1 finding, from 1 paper.
Structure
- Formula
- C16H8N2O8S2.2Na
- Mass
- 466.36 g/mol
- Charge
- 0
- InChIKey
- KHLVKKOJDHCJMG-QDBORUFSSA-L
- SMILES
- O=C1/C(=C2Nc3ccc(S(=O)(=O)[O-])cc3C2=O)Nc2ccc(S(=O)(=O)[O-])cc21.[Na+].[Na+]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What the evidence says
How to read these marks1 finding across 1 endpoint, from 1 paper, strongest first.
What moved
1 finding
Activates TYR
SpeculativeGrade F, Speculative. Mechanistic inference, or no evidence found.Finding“Significantly increased activities of spore laccase, intracellular tyrosinase, and lignin peroxidase upon exposure to indigo carmine were observed.”
Quoted verbatim from The Biodegradation of Indigo Carmine by Bacillus safensis HL3 Spore and Toxicity Analysis of the Degradation Products.. - Study
- in vitro · not in humans
- Population
- Bacillus safensis HL3 bacterial spores exposed to indigo carmine
The Biodegradation of Indigo Carmine by Bacillus safensis HL3 Spore and Toxicity Analysis of the Degradation Products.2022PMID:36500632
What the reference databases state
One step from indigo carmine in the reference databases: what it reacts with, is carried by, is converted to and takes part in.
Statements
1 statement
1 statement in 1 reference database name indigo carmine — ChEBI. Press a relation to see only its rows; every count is the rows behind it.
- indigo carmine is converted to indigo carmine (acid form)CompoundChEBI CHEBI:31695Inferred only
Registered, and not reported
Trials on ClinicalTrials.gov that list indigo carmine as an intervention, reached completed, terminated or suspended, and posted no results. What they found is not known, and that is the point.
Trials without posted results
45 trials
45 registered trials without posted results. 44 passed an actual primary completion date more than a year ago, which is the reporting window FDAAA 801 sets.
44 past the window1 within it, or no actual date
- NCT06446024completed2025-07-25industrypast the reporting window
- NCT04169243terminated— Post-pandemic women did not engage in unnecessary tasks. Changes were made (more languages and sites, short proof-of-concept study, easier recepies, food for whole family, social media, etc. After 4 yr 5 women were recruited and trial terminated2024-12-31a university or hospitalpast the reporting window
- NCT06596317completed2024-12-30a university or hospitalpast the reporting window
- NCT06777706completed2024-09-01a university or hospitalpast the reporting window
- NCT04297787completed2023-06-16a university or hospitalpast the reporting window
- NCT04291976completed2023-05-23a university or hospitalpast the reporting window
- NCT05153746completed2023-05-23a university or hospitalpast the reporting window
- NCT06910514completed2022-12-23industrypast the reporting window
- NCT04630925terminated— Staff shortage2022-11-16a university or hospitalpast the reporting window
- NCT04650945terminated— Staff shortage2022-11-16a university or hospitalpast the reporting window
- NCT05265221completed2022-05-31a university or hospitalpast the reporting window
- NCT04721678completed2022-02-15a government bodypast the reporting window
Show the remaining 33
- NCT03021135completed2022-01-19a university or hospitalpast the reporting window
- NCT03614221completed2021-12-01a university or hospitalpast the reporting window
- NCT02200978completed2021-10a university or hospitalpast the reporting window
- NCT04302896completed2021-09-30a university or hospitalpast the reporting window
- NCT04243668completed2021-09-02a university or hospitalpast the reporting window
- NCT05249023completed2021-02-19a university or hospitalpast the reporting window
- NCT06060106completed2021-01-01a university or hospitalpast the reporting window
- NCT04577053terminated— It was discovered during the study that Lyme Disease is a bio warfare weapon made in USA. (See "Bitten" by Kris Newby.) The second reason for stopping the study is lack of participant responses, likely due to lack of payment for completing surveys.2020-12-04a university or hospitalpast the reporting window
- NCT04065529completed2020-06-11industrypast the reporting window
- NCT05041179completed2020-04-01industrypast the reporting window
- NCT04455737completed2019-12a university or hospitalpast the reporting window
- NCT01755325suspended— not enough patientsexpected 2018-12a university or hospital
- NCT02570516completed2017-12a university or hospitalpast the reporting window
- NCT02951390completed2017-12a university or hospitalpast the reporting window
- NCT02543021completed2017-11-01a university or hospitalpast the reporting window
- NCT02661945completed2017-08a university or hospitalpast the reporting window
- NCT02669888completed2017-01a university or hospitalpast the reporting window
- NCT03117400completed2016-11a university or hospitalpast the reporting window
- NCT03476434completed2016-07a university or hospitalpast the reporting window
- NCT00905710completed2016-05a university or hospitalpast the reporting window
- NCT01836094completed2016-03a university or hospitalpast the reporting window
- NCT02354287completed2015-09-25a university or hospitalpast the reporting window
- NCT01901510completed2014-07a university or hospitalpast the reporting window
- NCT01735864completed2014-04a university or hospitalpast the reporting window
- NCT01901705completed2014-01a university or hospitalpast the reporting window
- NCT01880606completed2013-12a university or hospitalpast the reporting window
- NCT02088281completed2013-07a university or hospitalpast the reporting window
- NCT01383265completed2013-06US federal agencypast the reporting window
- NCT00961948completed2013-02a university or hospitalpast the reporting window
- NCT00274209completed2011-11a university or hospitalpast the reporting window
- NCT01521091completed2010-12a university or hospitalpast the reporting window
- NCT01182623completed2010-09-30a government bodypast the reporting window
- NCT00224601completed2008-01a university or hospitalpast the reporting window
Papers screened
25 papers
25 papers screened for indigo carmine. 1 produced a finding, 11 were read and discarded, 13 have not been read yet. Each group opens to the papers in it.
The whole record lists every paper, the query that retrieved it and the date it was decided.
Produced a finding1 paper
- PMID:365006322026-09-18
Discarded: an endpoint this vocabulary does not hold5 papers
- PMID:23341851no claim extracted — no_outcome_node — measured: chondrocyte cytotoxicity/viability (vital cell count, LDH release) after indigo carmine exposure, in vitro | chondrocyte cytotoxicity / LDH release marker of cell damage - no corresponding node in the outcome list2026-09-18
- PMID:28975476no claim extracted — no_outcome_node — measured: oxygen reserve index (ORi), a pulse co-oximetry-derived index of oxygen reserve, measured by ORi monitor | oxygen reserve index (ORi) via pulse co-oximetry - an optical-interference artefact of the dye's absorbance, not present in the outcome list2026-09-18
- PMID:38893568claims extracted but the object named resolved to no node — recorded in candidate_nodes (ADR-0070)2026-09-18
- PMID:39862274claims extracted but the object named resolved to no node — recorded in candidate_nodes (ADR-0070)2026-09-18
- PMID:42348977claims extracted but the object named resolved to no node — recorded in candidate_nodes (ADR-0070)2026-09-18
Discarded: the wrong intervention3 papers
- PMID:16100472no claim extracted — reagent_not_exposure2026-09-18
- PMID:30819492no claim extracted — reagent_not_exposure2026-09-18
- PMID:36143912no claim extracted — reagent_not_exposure2026-09-18
Discarded: no extractable result2 papers
- PMID:35274519no claim extracted — quote_over_cap2026-09-18
- PMID:38160534claims extracted but refused by the deterministic validators2026-09-18
Discarded: no comparator1 paper
- PMID:36804435no claim extracted — comparator_not_absence2026-09-18
Not read yet13 papers
- PMID:152760362026-09-01
- PMID:177172272026-09-01
- PMID:185736132026-09-01
- PMID:221122782026-09-01
- PMID:224343072026-09-01
- PMID:233444052026-09-01
- PMID:257144812026-09-01
- PMID:80482062026-09-01
- PMID:83636242026-09-01
- PMID:8417822026-09-01
- PMID:85670452026-09-01
- PMID:9332772026-09-01
and 1 more.
Sources cited
1 paper
The 1 finding about indigo carmine on this page come from 1 paper, newest first. The count beside each opens the first finding drawn from it.
Other names
22 names
Every name this graph resolves to indigo carmine. Searching any of them lands here.
- Also called
- C.I. Acid Blue 74C.I. Food Blue 1C.I. Food Blue 1, disodium saltC.I. Natural Blue 2Disodium 3,3'-dioxo-(delta2,2'-biindoline)-5,5'-disulfonateDisodium 5,5'-disulfoindigoDisodium 5,5'-indigotin disulfonateDisodium indigo-5,5-disulfonateE 132FD and C Blue No. 2FD&C Blue No. 2IndigocarmineIndigotin-5,5'-disulfonic acid disodium saltIndigotindisulfonate sodiumSodium 5,5'-indigotindisulfonateSodium indigo-5,5'-bisulfonateSodium indigotindisulfonate
- Systematic name
- disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate
- Sold as
- Acid blue 74C.I. 73015C.I. 75781Natural blue 2