know compoundsindigo carminepage read from the graph 2026-11-02

Specimen compound

Indigo carmine

Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.”
Definition from MeSH (D007203), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

Formula: C₁₆H₈N₂O₈S₂.₂Na
Molar mass: 466.36 g/mol
ChEBI: CHEBI:31695
MeSH: D007203
InChIKey: KHLVKKOJDHCJMG-QDBORUFSSA-L

1findings
1endpoints
1papers

Structure

2D depiction

No three-dimensional record for this entry.

Formula: C16H8N2O8S2.2Na
Mass: 466.36 g/mol
Charge: 0
InChIKey: KHLVKKOJDHCJMG-QDBORUFSSA-L
SMILES: O=C1/C(=C2Nc3ccc(S(=O)(=O)[O-])cc3C2=O)Nc2ccc(S(=O)(=O)[O-])cc21.[Na+].[Na+]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

01 · the evidence, ordered

What the evidence says

: Strong; 0
: Moderate; 0
: Limited; 0
: Very limited; 0
: Insufficient; 1

How to read these marks

Fig. 1 indigo carmine CHEBI:316951 endpoint 1 finding on ring 1 ring 2 on requestSel indigo carmine · centre · ring 0

×1.00

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CompoundInspector

indigo carmine

CHEBI:31695

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Findings drawn, by strength

1finding · 1 endpoint

Insufficient1

Most findings

ring 0 · 1 endpoint on ring 1 · 1 reference statement, not drawn

← → round a ring↑ ↓ out and inEnter selecte one more ringf fit to view+ − zoomEsc clearclick a node to select it

Activates TYR

fig. 2 · 1 endpoint · 1 finding · one mark per findingno endpoint contested

02 · findings

What indigo carmine moved, and by how much

Dose studied: as its paper gave it. No dose is advised.
Evidence strength: computed from the study. How it is computed

1 row · 1 finding in the record

TYRMoved: activatesEffect, as reportednot reportedEvidence: InsufficientPaper: PMID:365006322022
Who
Bacillus safensis HL3 bacterial spores exposed to indigo carmine
Dose studied
not reported
Significantly increased activities of spore laccase, intracellular tyrosinase, and lignin peroxidase upon exposure to indigo carmine were observed.”
Quoted verbatim from The Biodegradation of Indigo Carmine by Bacillus safensis HL3 Spore and Toxicity Analysis of the Degradation Products.in vitro · not in humansPermalink

No dose is advised.

03 · interactions

Taken with something else

Documented interactions: None reported

Pairs that share biology

What the reference databases state

Reference statements: 101 Compoundindigo carmine (acid form)inferred, one hop from indigo carmine
Trials · ClinicalTrials.gov: 45without posted results · 44 past the reporting window

1 reference statement

What the reference databases state

Evidence key

Statements

1 statement

1 statement · 1 reference database · Subject: indigo carmine · Sources: ChEBI

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indigo carmine is converted to indigo carmine (acid form)CompoundChEBI CHEBI:31695Inferred only

1 of 1 statement

All 45 registered trials

Registered, and not reported

Source: ClinicalTrials.gov
Intervention: indigo carmine
Status: Completed, terminated or suspended
Results posted: No

Trials without posted results

45 trials

45 registered trials without posted results · Overdue (FDAAA 801): 44

44 past the window1 within it, or no actual date

Search this list

NCT06446024completed2025-07-25industrypast the reporting window
NCT04169243terminated· Post-pandemic women did not engage in unnecessary tasks. Changes were made (more languages and sites, short proof-of-concept study, easier recepies, food for whole family, social media, etc. After 4 yr 5 women were recruited and trial terminated2024-12-31a university or hospitalpast the reporting window
NCT06596317completed2024-12-30a university or hospitalpast the reporting window
NCT06777706completed2024-09-01a university or hospitalpast the reporting window
NCT04297787completed2023-06-16a university or hospitalpast the reporting window
NCT04291976completed2023-05-23a university or hospitalpast the reporting window
NCT05153746completed2023-05-23a university or hospitalpast the reporting window
NCT06910514completed2022-12-23industrypast the reporting window
NCT04630925terminated· Staff shortage2022-11-16a university or hospitalpast the reporting window
NCT04650945terminated· Staff shortage2022-11-16a university or hospitalpast the reporting window
NCT05265221completed2022-05-31a university or hospitalpast the reporting window
NCT04721678completed2022-02-15a government bodypast the reporting window

Show the remaining 33

Every trial, as data

04 · the record

What was read to make this page

258

papers screened for indigo carmine

admitted: 0
read and discarded: 190
not read yet: 68

The screening record, every paper and why

Sources cited

1 paper · 1 finding

1Show every paper cited

Every paper cited, on one page

Other names · 22

C.I. Acid Blue 74 · C.I. Food Blue 1 · C.I. Food Blue 1, disodium salt · C.I. Natural Blue 2 · Disodium 3,3'-dioxo-(delta2,2'-biindoline)-5,5'-disulfonate · Disodium 5,5'-disulfoindigo · Disodium 5,5'-indigotin disulfonate · Disodium indigo-5,5-disulfonate · E 132 · FD and C Blue No. 2 · FD&C Blue No. 2 · Indigocarmine · Indigotin-5,5'-disulfonic acid disodium salt · Indigotindisulfonate sodium · Sodium 5,5'-indigotindisulfonate · Sodium indigo-5,5'-bisulfonate · Sodium indigotindisulfonate

systematic · disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1,3-dihydro-2H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate

sold as · Acid blue 74 · C.I. 73015 · C.I. 75781 · Natural blue 2