Compound
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
Conjugate base of (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oic acid.
Definition from ChEBI (CHEBI:58734), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C27H45O5
- Mass
- 449.652 g/mol
- Charge
- -1
- InChIKey
- CNWPIIOQKZNXBB-WBYPBBSPSA-M
- SMILES
- [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCC[C@@H](C)C(=O)[O-])[C@]1([H])[C@H](O)C2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
13 entities
13 entities reached.
0 reported hops13 assembled from the scaffold
- SLC27A2ProteinUNIPROT:O14975substrate of, transported byInferred only92 paths33 endpoints
- ABCD3ProteinUNIPROT:P28288transported byInferred only87 paths82 endpoints
- SLC27A5ProteinUNIPROT:Q9Y2P5substrate of, transported byInferred only51 paths17 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- ALDH2ProteinUNIPROT:P05091metabolized byInferred only32 paths32 endpoints
- CYP27A1ProteinUNIPROT:Q02318metabolized byInferred only29 paths29 endpoints
- ALDH3A1ProteinUNIPROT:P30838metabolized byInferred only16 paths8 endpoints
- ALDH3A2ProteinUNIPROT:P51648metabolized byInferred only14 paths14 endpoints
- ALDH7A1ProteinUNIPROT:P49419metabolized byInferred only13 paths13 endpoints
- ALDH1B1ProteinUNIPROT:P30837metabolized byInferred only11 paths11 endpoints
- ALDH9A1ProteinUNIPROT:P49189metabolized byInferred only7 paths7 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only4 paths3 endpoints
Show the remaining 1
What the reference databases state
Statements
35 statements
35 statements · 1 reference database · Subject: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate · Sources: Human-GEM
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR03821Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-alCompoundHuman-GEM MAR03210Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-alCompoundHuman-GEM MAR03214Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-alCompoundHuman-GEM MAR03815Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-alCompoundHuman-GEM MAR03817Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-alCompoundHuman-GEM MAR03821Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR01611Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR01613Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR01614Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR03210Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR03214Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al is converted to (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oateCompoundHuman-GEM MAR03815Inferred only
Show the remaining 23
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH1B1ProteinHuman-GEM MAR03817Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH2ProteinHuman-GEM MAR03817Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH3A1ProteinHuman-GEM MAR03821Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH3A1ProteinHuman-GEM MAR03815Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH3A2ProteinHuman-GEM MAR03821Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH7A1ProteinHuman-GEM MAR03817Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by ALDH9A1ProteinHuman-GEM MAR03815Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is metabolised by CYP27A1ProteinHuman-GEM MAR03214Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is a substrate of SLC27A2ProteinHuman-GEM MAR01627Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is a substrate of SLC27A2ProteinHuman-GEM MAR01624Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is a substrate of SLC27A2ProteinHuman-GEM MAR01625Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is a substrate of SLC27A5ProteinHuman-GEM MAR01627Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is a substrate of SLC27A5ProteinHuman-GEM MAR01625Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is a substrate of SLC27A5ProteinHuman-GEM MAR01624Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by ABCB11ProteinHuman-GEM MAR11377Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by ABCC11ProteinHuman-GEM MAR11377Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by ABCC3ProteinHuman-GEM MAR11377Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by ABCD3ProteinHuman-GEM MAR01622Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by SLC10A1ProteinHuman-GEM MAR11378Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by SLC27A2ProteinHuman-GEM MAR01620Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by SLC27A2ProteinHuman-GEM MAR01619Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by SLC27A5ProteinHuman-GEM MAR01619Inferred only
- (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate is transported by SLC27A5ProteinHuman-GEM MAR01620Inferred only
Reactions
23 reactions
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al+water+NAD(+)(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+2proton+NADH(2-)
Catalysed by CYP27A1
Reaction pageLeft to rightBalancedEC 1.14.15.15GO:0005829
Human-GEM MAR01611CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al+NADH(2-)+dioxygen(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+water+NAD(+)
Catalysed by CYP27A1
Reaction pageLeft to rightBalancedEC 1.14.15.15GO:0005759
Human-GEM MAR01613CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al+NADPH(4-)+dioxygen(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+water+NADP(3-)
Catalysed by CYP27A1
Reaction pageLeft to rightBalancedEC 1.14.15.15GO:0005759
Human-GEM MAR01614CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
Transported by SLC27A5 or SLC27A2
Reaction pageReversibleBalancedEC 6.2.1.7GO:0005829, GO:0005783
Human-GEM MAR01619CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
Transported by SLC27A5 or SLC27A2
Reaction pageReversibleBalancedEC 6.2.1.7GO:0005829, GO:0005759
Human-GEM MAR01620CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+water(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ADP+proton+phosphate(3-)
Transported by ABCD3
Reaction pageLeft to rightBalancedGO:0005829, GO:0005777
Human-GEM MAR01622CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
Reaction pageReversibleBalancedGO:0005829, GO:0005777
Human-GEM MAR01623CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+CHEBI:1146900(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7GO:0005783
Human-GEM MAR01624CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+CHEBI:1146900(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7GO:0005777
Human-GEM MAR01625CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+ATP+CHEBI:1146900(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7GO:0005829
Human-GEM MAR01627CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
Reaction pageReversibleBalancedEC 2.3.1.21GO:0005759, GO:0005777
Human-GEM MAR01779CC BY 4.0Reference data
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al+water+NADP(3-)(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate+2proton+NADPH(4-)
Reaction pageReversibleBalancedGO:0005829
Human-GEM MAR03210CC BY 4.0Reference data
Where it reaches
10 systems, 26 regions, 89 tissues, 124 transporter routes — routes, not measurements: transporters known to carry (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate are expressed there, and no source reports it arriving.
Loading the model…
Other names
3 names
Resolves to: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate
- Also called
- (3alpha,5beta,7alpha,12alpha,25R)-3,7,12-trihydroxycholestan-26-oate(3α,5β,7α,12α,25R)-3,7,12-trihydroxycholestan-26-oate
- Systematic name
- (25R)-3α,7α,12α-trihydroxy-5β-cholestan-26-oate