Compound
17beta-estradiol 17-O-(beta-D-glucuronate)
A monocarboxylic acid anion resulting from the deprotonation of the carboxy group of 17β-estradiol 17-glucosiduronic acid.
Definition from ChEBI (CHEBI:82961), read 2026-09-23. CC BY 4.0.
Structure
- Class
- Organic compound, anion
- Formula
- C24H31O8
- Mass
- 447.504 g/mol
- Charge
- -1
- InChIKey
- MTKNDAQYHASLID-QXYWQCSFSA-M
- SMILES
- [H][C@@]12CCc3cc(O)ccc3[C@@]1([H])CC[C@]1(C)[C@@H](O[C@@H]3O[C@H](C(=O)[O-])[C@@H](O)[C@H](O)[C@H]3O)CC[C@@]21[H]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
11 entities
11 entities reached.
0 reported hops11 assembled from the scaffold
- ABCA8ProteinUNIPROT:O94911transported byInferred only49 paths48 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- ABCC2ProteinUNIPROT:Q92887transported byInferred only15 paths15 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- CHST10ProteinUNIPROT:O43529substrate ofInferred only10 paths10 endpoints
- SLCO4A1ProteinUNIPROT:Q96BD0transported byInferred only4 paths4 endpoints
- SLCO1B1ProteinUNIPROT:Q9Y6L6transported byInferred only3 paths2 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only3 paths2 endpoints
- ABCC1ProteinUNIPROT:P33527transported byInferred only2 paths2 endpoints
- SLCO1C1ProteinUNIPROT:Q9NYB5transported byInferred only2 paths2 endpoints
What the reference databases state
Statements
18 statements
18 statements · 1 reference database · Subject: 17beta-estradiol 17-O-(beta-D-glucuronate) · Sources: Rhea
- 17beta-estradiol is converted to 17beta-estradiol 17-O-(beta-D-glucuronate)CompoundRhea RHEA:52464Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is converted to 17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)CompoundRhea RHEA:68664Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is a substrate of CHST10ProteinRhea RHEA:68664Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCA8ProteinRhea RHEA:65968Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCC1ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCC10ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCC11ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCC2ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCC3ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCC4ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by ABCG2ProteinRhea RHEA:60128Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLC22A24ProteinRhea RHEA:72155Inferred only
Show the remaining 6
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLCO1A2ProteinRhea RHEA:72691Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLCO1B1ProteinRhea RHEA:72691Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLCO1B3ProteinRhea RHEA:72691Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLCO1B3-SLCO1B7ProteinRhea RHEA:72691Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLCO1C1ProteinRhea RHEA:72691Inferred only
- 17beta-estradiol 17-O-(beta-D-glucuronate) is transported by SLCO4A1ProteinRhea RHEA:72691Inferred only
Reactions
6 reactions
17beta-estradiol+UDP-alpha-D-glucuronate17beta-estradiol 17-O-(beta-D-glucuronate)+UDP+hydron
Catalysed by UGT2B17 or UGT2A1 or UGT2B7 or UGT1A3 or UGT1A10
Reaction pageLeft to rightBalanced
Rhea RHEA:52464CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)+ATP(4-)+water17beta-estradiol 17-O-(beta-D-glucuronate)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCC3 or ABCC4 or ABCC1 or ABCC10 or ABCC2 or ABCC11 or ABCG2
Reaction pageLeft to rightBalanced
Rhea RHEA:60128CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)+ATP(4-)+water17beta-estradiol 17-O-(beta-D-glucuronate)+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8
Reaction pageLeft to rightBalanced
Rhea RHEA:65968CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)+3'-phosphoadenylyl sulfate17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)+adenosine 3',5'-bisphosphate+hydron
Catalysed by CHST10
Reaction pageLeft to rightBalanced
Rhea RHEA:68664CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)+glutarate17beta-estradiol 17-O-(beta-D-glucuronate)+glutarate
Transported by SLC22A24
Reaction pageDirection not assertedBalanced
Rhea RHEA:72155CC BY 4.0Reference data
17beta-estradiol 17-O-(beta-D-glucuronate)17beta-estradiol 17-O-(beta-D-glucuronate)
Transported by SLCO1B3-SLCO1B7 or SLCO1A2 or SLCO4A1 or SLCO1B3 or SLCO1C1 or SLCO1B1
Reaction pageLeft to rightBalanced
Rhea RHEA:72691CC BY 4.0Reference data
Where it reaches
9 systems, 24 regions, 84 tissues, 116 transporter routes — routes, not measurements: transporters known to carry 17beta-estradiol 17-O-(beta-D-glucuronate) are expressed there, and no source reports it arriving.
Loading the model…
Other names
4 names
Resolves to: 17beta-estradiol 17-O-(beta-D-glucuronate)
- Also called
- 17beta-estradiol 17-glucuronate17β-estradiol 17-glucuronate
- Systematic name
- (17beta)-3-hydroxyestra-1,3,5(10)-trien-17-yl beta-D-glucopyranosiduronate(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl β-D-glucopyranosiduronate