Endpoint
Blood haemoglobin concentration
CAT:outcome/blood-haemoglobinreported in g/L3 findings from 3 compounds
What moved it
How to read these marks3 findings · 3 compounds · 2 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| coenzyme Q10 | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Cordyceps militaris | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| methylene blue | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
Cordyceps militaris — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Importantly, the change rates of hemoglobin and hematocrit were significantly increased in the CM group compared with those in the placebo group at 8 weeks after the test food intake (p < 0.05) A,B).”
Quoted verbatim from Effect of the Administration of Cordyceps militaris Mycelium Extract on Blood Markers for Anemia in Long-Distance Runners.. - Study
- RCT
- Duration
- 8 weeks
- Dose
- 1800 mg/day (6 capsules of 300 mg each; 3 morning, 3 evening)
- Population
- Healthy male long-distance runners during pre-season training; hemoglobin change rate from baseline measured at 8 weeks into the 16-week intervention.
Effect of the Administration of Cordyceps militaris Mycelium Extract on Blood Markers for Anemia in Long-Distance Runners.2024PMID:38931190Industry fundedPermalink
Measured, no effect detected
2 findings
coenzyme Q10 — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, there were no significant differences in hematological parameters (RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC, lymphocyte, neutrophil, and platelet) between CoQ10 and placebo groups at the end of the study (P > 0.05).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; secondary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
methylene blue — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“There were no differences between CQ and CQ-MB study groups in haemoglobin and haematocrit values over time in both the G6PD deficient and sufficient subgroups (Table 3).”
Quoted verbatim from Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].. - Study
- RCT
- Duration
- 14 days
- Dose
- 0.5% MB solution 4 mg/kg/day for three days, plus chloroquine 25 mg/kg over three days
- Population
- children aged 6-59 months with uncomplicated falciparum malaria, Burkina Faso; chloroquine given to both arms; result stated for G6PD deficient and G6PD sufficient subgroups
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].2005PMID:16179085Permalink
How it is measured
Haemoglobin concentration in whole blood by automated haematology analyser. Sample site and posture recorded with each finding — capillary samples read higher than venous, and supine sampling reads lower than seated through plasma volume shift.
Sources cited
3 papers
- Subject
- blood haemoglobin concentration
- Findings
- 3
- Papers
- 3
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.record2024PMID:384316001 finding
Effect of the Administration of Cordyceps militaris Mycelium Extract on Blood Markers for Anemia in Long-Distance Runners.record2024PMID:389311901 finding
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].record2005PMID:161790851 finding