Blood haemoglobin concentration

Method

Haemoglobin concentration in whole blood by automated haematology analyser. Sample site and posture recorded on the edge — capillary samples read higher than venous, and supine sampling reads lower than seated through plasma volume shift.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

Confused by name alone with glycated haemoglobin (HbA1c), which is a glycaemic control measure in percent or mmol/mol that improves by FALLING and shares nothing with this endpoint but a word — a SIGN INVERSION across two unrelated constructs, and the most likely one to arise from string matching. Also confused with the incidence of anaemia as a dichotomous event: a mean rise of a few grams per litre need not move the proportion of patients below a diagnostic threshold, so a positive continuous effect and a null dichotomous effect are consistent. Haematocrit is a separate node measuring packed cell volume and moves with plasma volume.

Findings

1 finding from 1 compound, strongest first.

• coenzyme Q10 — no detected effect on

  BLikelyGrade B, Likely. Human evidence, limited replication or design limits.FindingNull result

  “As shown in Table  2, there were no significant differences in hematological parameters (RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, WBC, lymphocyte, neutrophil, and platelet) between CoQ10 and placebo groups at the end of the study (P > 0.05).”

  Study

  RCT

  Participants

  52

  Duration

  10 days

  Dose

  100 mg three times a day after meals, total 300 mg/day

  Population

  Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; secondary outcome.

  Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600