Compound
(6R)-5,10-methylenetetrahydrofolic acid
The (6R)-stereoisomer of 5,10-methylenetetrahydrofolic acid.
Definition from ChEBI (CHEBI:1989), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
18 entities
18 entities reached.
0 reported hops18 assembled from the scaffold
- MTHFD1ProteinUNIPROT:P11586substrate ofInferred only57 paths19 endpoints
- MTHFRProteinUNIPROT:P42898substrate ofInferred only36 paths18 endpoints
- SHMT2ProteinUNIPROT:P34897substrate ofInferred only30 paths30 endpoints
- MTHFD2ProteinUNIPROT:P13995substrate ofInferred only26 paths13 endpoints
- TYMSProteinUNIPROT:P04818substrate ofInferred only24 paths24 endpoints
- SHMT1ProteinUNIPROT:P34896substrate ofInferred only22 paths22 endpoints
- ABCC2ProteinUNIPROT:Q92887transported byInferred only15 paths15 endpoints
- ABCG2ProteinUNIPROT:Q9UNQ0transported byInferred only14 paths14 endpoints
- ABCC5ProteinUNIPROT:O15440transported byInferred only11 paths11 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- ABCB4ProteinUNIPROT:P21439transported byInferred only8 paths7 endpoints
- MTHFD1LProteinUNIPROT:Q6UB35substrate ofInferred only7 paths7 endpoints
Show the remaining 6
- MTHFD2LProteinUNIPROT:Q9H903substrate ofInferred only6 paths6 endpoints
- FOLR1ProteinUNIPROT:P15328transported byInferred only5 paths5 endpoints
- ABCC1ProteinUNIPROT:P33527transported byInferred only2 paths2 endpoints
- SLC19A1ProteinUNIPROT:P41440transported byInferred only2 paths2 endpoints
- SLC46A1ProteinUNIPROT:Q96NT5transported byInferred only2 paths2 endpoints
- FOLR3ProteinUNIPROT:P41439transported byInferred only1 path1 endpoint
What the reference databases state
Statements
34 statements
34 statements · 1 reference database · Subject: (6R)-5,10-methylenetetrahydrofolic acid · Sources: Human-GEM
- (6R)-5,10-methenyltetrahydrofolate is converted to (6R)-5,10-methylenetetrahydrofolic acidCompoundHuman-GEM MAR08144Inferred only
- (6R)-5,10-methenyltetrahydrofolate is converted to (6R)-5,10-methylenetetrahydrofolic acidCompoundHuman-GEM MAR04444Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to (6R)-5,10-methenyltetrahydrofolateCompoundHuman-GEM MAR08144Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to (6R)-5,10-methenyltetrahydrofolateCompoundHuman-GEM MAR04444Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to (6R)-5,10-methenyltetrahydrofolateCompoundHuman-GEM MAR04442Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to (6R)-5,10-methenyltetrahydrofolateCompoundHuman-GEM MAR04440Inferred only
- (6R)-5,10-methenyltetrahydrofolate is converted to (6R)-5,10-methylenetetrahydrofolic acidCompoundHuman-GEM MAR04440Inferred only
- (6R)-5,10-methenyltetrahydrofolate is converted to (6R)-5,10-methylenetetrahydrofolic acidCompoundHuman-GEM MAR04442Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to 5-methyltetrahydrofolic acidCompoundHuman-GEM MAR04448Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is converted to 5-methyltetrahydrofolic acidCompoundHuman-GEM MAR04446Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD1ProteinHuman-GEM MAR04444Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD1ProteinHuman-GEM MAR08144Inferred only
Show the remaining 22
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD1ProteinHuman-GEM MAR04442Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD1LProteinHuman-GEM MAR04444Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD2ProteinHuman-GEM MAR04444Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD2ProteinHuman-GEM MAR04440Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFD2LProteinHuman-GEM MAR04440Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFRProteinHuman-GEM MAR04448Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of MTHFRProteinHuman-GEM MAR04446Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of SHMT1ProteinHuman-GEM MAR03845Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of SHMT2ProteinHuman-GEM MAR04792Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is a substrate of TYMSProteinHuman-GEM MAR04644Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCB4ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCC1ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCC11ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCC2ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCC4ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCC5ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by ABCG2ProteinHuman-GEM MAR11809Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by FOLR1ProteinHuman-GEM MAR11800Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by FOLR2ProteinHuman-GEM MAR11800Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by FOLR3ProteinHuman-GEM MAR11800Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by SLC19A1ProteinHuman-GEM MAR11805Inferred only
- (6R)-5,10-methylenetetrahydrofolic acid is transported by SLC46A1ProteinHuman-GEM MAR11787Inferred only
Reactions
19 reactions
L-seryl residue+5,6,7,8-tetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid+glycine+water
Catalysed by SHMT1
Reaction pageReversibleBalancedEC 2.1.2.1GO:0005829
Human-GEM MAR03845CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR03950CC BY 4.0Reference data
formaldehyde+5,6,7,8-tetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid+water
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR03972CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADH(2-)(6R)-5,10-methylenetetrahydrofolic acid+NAD(+)
Catalysed by MTHFD2 or MTHFD2L
Reaction pageReversibleBalancedEC 1.5.1.15GO:0005759
Human-GEM MAR04440CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADPH(4-)(6R)-5,10-methylenetetrahydrofolic acid+NADP(3-)
Catalysed by MTHFD1
Reaction pageReversibleBalancedEC 1.5.1.5GO:0005829
Human-GEM MAR04442CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADPH(4-)(6R)-5,10-methylenetetrahydrofolic acid+NADP(3-)
Catalysed by MTHFD2 or MTHFD1 or MTHFD1L
Reaction pageReversibleBalancedEC 1.5.1.5GO:0005759
Human-GEM MAR04444CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADPH(4-)5-methyltetrahydrofolic acid+NADP(3-)
Catalysed by MTHFR
Reaction pageLeft to rightBalancedEC 1.5.1.20GO:0005829
Human-GEM MAR04446CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+2proton+NADH(2-)5-methyltetrahydrofolic acid+NAD(+)
Catalysed by MTHFR
Reaction pageLeft to rightBalancedEC 1.5.1.20GO:0005829
Human-GEM MAR04448CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+dUMP7,8-dihydrofolate+dTMP
Catalysed by TYMS
Reaction pageLeft to rightBalancedEC 2.1.1.45GO:0005829
Human-GEM MAR04644CC BY 4.0Reference data
(6R)-5,10-methylenetetrahydrofolic acid+glycine+waterL-seryl residue+5,6,7,8-tetrahydrofolic acid
Catalysed by SHMT2
Reaction pageReversibleBalancedEC 2.1.2.1GO:0005759
Human-GEM MAR04792CC BY 4.0Reference data
(6R)-5,10-methenyltetrahydrofolate+NADH(2-)(6R)-5,10-methylenetetrahydrofolic acid+NAD(+)
Catalysed by MTHFD1
Reaction pageReversibleBalancedEC 1.5.1.5GO:0005829
Human-GEM MAR08144CC BY 4.0Reference data
FAD+CHEBI:15611+5,6,7,8-tetrahydrofolic acid(6R)-5,10-methylenetetrahydrofolic acid+FADH2+glycine
Catalysed by SARDH
Reaction pageLeft to rightBalancedEC 1.5.8.3GO:0005759
Human-GEM MAR08432CC BY 4.0Reference data
Where it reaches
5 systems, 12 regions, 34 tissues, 45 transporter routes — routes, not measurements: transporters known to carry (6R)-5,10-methylenetetrahydrofolic acid are expressed there, and no source reports it arriving.
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Other names
5 names
Resolves to: (6R)-5,10-methylenetetrahydrofolic acid
- Also called
- (6R)-5,10-Methylenetetrahydrofolate5,10-Methylene-THF5,10-Methylenetetrahydrofolate5,10-methylenetetrahydrofolic acid
- Systematic name
- N-{4-[(6aR)-3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid