Endpoint
WOMAC pain subscale
CAT:outcome/womac-pain-subscalereported in points1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| glucosamine | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
glucosamine — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As for WOMAC pain scores (Fig., the summarized effect size was − 0.04 ([95% CI] − 0.13, 0.06), suggesting a favorable but not significant effect of glucosamine on knee pain as measured by WOMAC.”
Quoted verbatim from Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- pooled across trials: five used a sulfate salt of glucosamine (two of them Rottapharm/Madaus crystalline glucosamine sulfate), six used the hydrochloride salt, one used N-acetylated glucosamine, unclear for the rest; 1500 mg/day in most studies per the Discussion, per-trial doses not tabulated in Table 1
- Population
- Adults with knee osteoarthritis in randomised placebo-controlled trials published between 2003 and 2016; the pooled trials include both glucosamine given alone and commercial supplements combining glucosamine with other components, chondroitin among them.
Effect -0.04 standardised mean difference, 95% CI -0.13 to 0.06
Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis.2018PMID:29713967Permalink
How it is measured
Western Ontario and McMaster Universities Osteoarthritis Index pain subscale, 5 items, administered in Likert (0-20) or visual-analogue format. The format and whether the score was normalised to 0-100 are recorded with each finding.
Measured, not recorded
- Subject
- womac pain subscale
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
WOMAC pain subscale
decreases, p = 0.001, n = 1457
pain (4 articles; 1457 patients; MD= -1.63; 95% CI, -2.63 to -0.63; P = 0.001)
PMID:37198620 · one of two readings recorded this
Sources cited
1 paper
- Subject
- womac pain subscale
- Findings
- 1
- Papers
- 1