Compound
androst-4-ene-3,17-dione
No description recorded for this entry yet. Everything this graph holds about androst-4-ene-3,17-dione is below.
CHEBI:16422ChEBI
Structure
- Class
- Organic compound
- Formula
- C19H26O2
- Mass
- 286.415 g/mol
- Charge
- 0
- InChIKey
- AEMFNILZOJDQLW-QAGGRKNESA-N
- SMILES
- [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What it touches on the way
A finding says androst-4-ene-3,17-dione moved an endpoint. This is the biology in between: the proteins and reactions it runs through to get there. It is where to look for the two things a list of findings cannot answer — why a result might happen, and what else acts on the same machinery.
29 of these are proteins with a page of their own, and that is the door: a protein page says what else it carries, which is how one compound leads to the next.
Mechanistic reach
29 entities
29 entities reached, most connected first. Hub metabolites are excluded, so this is not a claim that the compound touches everything.
0 reported hops29 assembled from the scaffold
- CYP17A1ProteinUNIPROT:P05093metabolized byInferred only132 paths22 endpoints
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only108 paths27 endpoints
- CYP19A1ProteinUNIPROT:P11511metabolized byInferred only100 paths25 endpoints
- HSD3B1ProteinUNIPROT:P14060substrate ofInferred only72 paths18 endpoints
- HSD3B2ProteinUNIPROT:P26439substrate ofInferred only72 paths18 endpoints
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only48 paths48 endpoints
- HSD17B3ProteinUNIPROT:P37058substrate ofInferred only48 paths16 endpoints
- HSD17B1ProteinUNIPROT:P14061substrate ofInferred only45 paths15 endpoints
- AKR1C4ProteinUNIPROT:P17516substrate ofInferred only42 paths21 endpoints
- SRD5A3ProteinUNIPROT:Q9H8P0substrate ofInferred only36 paths18 endpoints
- AKR1D1ProteinUNIPROT:P51857substrate ofInferred only30 paths15 endpoints
- HSD17B2ProteinUNIPROT:P37059substrate ofInferred only27 paths9 endpoints
Show the remaining 17
- HSD17B7ProteinUNIPROT:P56937substrate ofInferred only26 paths13 endpoints
- CYP2D6ProteinUNIPROT:P10635metabolized byInferred only24 paths24 endpoints
- GSTA1ProteinUNIPROT:P08263metabolized byInferred only21 paths21 endpoints
- CYP11B1ProteinUNIPROT:P15538metabolized byInferred only20 paths20 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only20 paths20 endpoints
- SRD5A1ProteinUNIPROT:P18405substrate ofInferred only19 paths11 endpoints
- HSD17B6ProteinUNIPROT:O14756substrate ofInferred only16 paths4 endpoints
- HSD17B10ProteinUNIPROT:Q99714substrate ofInferred only16 paths16 endpoints
- CYP3A5ProteinUNIPROT:P20815metabolized byInferred only15 paths15 endpoints
- GSTA3ProteinUNIPROT:Q16772metabolized byInferred only14 paths14 endpoints
- SRD5A2ProteinUNIPROT:P31213substrate ofInferred only13 paths13 endpoints
- ABCB1ProteinUNIPROT:P08183transported byInferred only12 paths11 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only12 paths12 endpoints
- HSD17B12ProteinUNIPROT:Q53GQ0substrate ofInferred only9 paths9 endpoints
- HSD17B8ProteinUNIPROT:Q92506substrate ofInferred only9 paths3 endpoints
- AKR1B15ProteinUNIPROT:C9JRZ8substrate ofInferred only5 paths5 endpoints
- HSD17B11ProteinUNIPROT:Q8NBQ5substrate ofInferred only3 paths2 endpoints
What the reference databases state
The section above shows paths a projection assembled. This is the reference layer itself, one step from androst-4-ene-3,17-dione: what the cleared databases state it reacts with, is carried by, is converted to and takes part in, whether or not a projection has walked it yet.
Regulatory determinations
Published numbers and scores, transcribed from the body that issued them. A determination is not a finding and is not graded; it is the number, who set it, and the document it came from.
LiverTox likelihood score ALiverTox
LiverTox Likelihood Score A — well known, well described and well reported to cause liver injury. Chapter: "Androstenedione". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not graded
Statements
76 statements
76 statements in 2 reference databases name androst-4-ene-3,17-dione — Human-GEM, Rhea. Press a relation to see only its rows; every count is the rows behind it.
- androst-4-ene-3,17-dione is converted to 5alpha-androstan-3,17-dioneCompoundRhea RHEA:50816Inferred only
- 5alpha-androstan-3,17-dione is converted to androst-4-ene-3,17-dioneCompoundRhea RHEA:50816Inferred only
- androst-4-ene-3,17-dione is converted to 5beta-androstane-3,17-dioneCompoundRhea RHEA:46656Inferred only
- 5beta-androstane-3,17-dione is converted to androst-4-ene-3,17-dioneCompoundRhea RHEA:46656Inferred only
- androst-5-ene-3,17-dione is converted to androst-4-ene-3,17-dioneCompoundRhea RHEA:43936Inferred only
- androst-4-ene-3,17-dione is converted to androst-5-ene-3,17-dioneCompoundRhea RHEA:43936Inferred only
- CHEBI:24636 is converted to androst-4-ene-3,17-dioneCompoundHuman-GEM MAR01971Inferred only
- CHEBI:24636 is converted to androst-4-ene-3,17-dioneCompoundHuman-GEM MAR01970Inferred only
- androst-4-ene-3,17-dione is converted to testosteroneCompoundRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is converted to testosteroneCompoundRhea RHEA:14929Inferred only
- testosterone is converted to androst-4-ene-3,17-dioneCompoundRhea RHEA:14929Inferred only
- testosterone is converted to androst-4-ene-3,17-dioneCompoundRhea RHEA:14981Inferred only
Show the remaining 64
- androst-4-ene-3,17-dione is metabolised by CYP11B1ProteinRhea RHEA:84071Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP17A1ProteinRhea RHEA:14753Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP17A1ProteinRhea RHEA:53228Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP17A1ProteinHuman-GEM MAR07938Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP17A1ProteinHuman-GEM MAR01985Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP17A1ProteinHuman-GEM MAR01987Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP17A1ProteinHuman-GEM MAR02723Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP19A1ProteinRhea RHEA:38195Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP19A1ProteinHuman-GEM MAR07940Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP19A1ProteinHuman-GEM MAR02032Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP19A1ProteinRhea RHEA:38199Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP2D6ProteinHuman-GEM MAR09937Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP3A4ProteinRhea RHEA:47256Inferred only
- androst-4-ene-3,17-dione is metabolised by CYP3A5ProteinRhea RHEA:47256Inferred only
- androst-4-ene-3,17-dione is metabolised by GSTA1ProteinRhea RHEA:43936Inferred only
- androst-4-ene-3,17-dione is metabolised by GSTA3ProteinRhea RHEA:43936Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1B15ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C1ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C2ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C3ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C3ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C3ProteinRhea RHEA:14929Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C3ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C4ProteinRhea RHEA:14929Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1C4ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1D1ProteinHuman-GEM MAR02014Inferred only
- androst-4-ene-3,17-dione is a substrate of AKR1D1ProteinRhea RHEA:46656Inferred only
- androst-4-ene-3,17-dione is a substrate of DHRS1ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B1ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B1ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B1ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B10ProteinRhea RHEA:14929Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B11ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B11ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B12ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B2ProteinHuman-GEM MAR07955Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B2ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B2ProteinRhea RHEA:14929Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B3ProteinRhea RHEA:14981Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B3ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B3ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B6ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B6ProteinRhea RHEA:14929Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B6ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B6ProteinHuman-GEM MAR07955Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B7ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B7ProteinHuman-GEM MAR01974Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B8ProteinHuman-GEM MAR01973Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B8ProteinHuman-GEM MAR07955Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD17B8ProteinRhea RHEA:14929Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B1ProteinHuman-GEM MAR07954Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B1ProteinRhea RHEA:43936Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B1ProteinHuman-GEM MAR01970Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B1ProteinHuman-GEM MAR01971Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B2ProteinRhea RHEA:43936Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B2ProteinHuman-GEM MAR01970Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B2ProteinHuman-GEM MAR07954Inferred only
- androst-4-ene-3,17-dione is a substrate of HSD3B2ProteinHuman-GEM MAR01971Inferred only
- androst-4-ene-3,17-dione is a substrate of SRD5A1ProteinRhea RHEA:50816Inferred only
- androst-4-ene-3,17-dione is a substrate of SRD5A1ProteinHuman-GEM MAR02015Inferred only
- androst-4-ene-3,17-dione is a substrate of SRD5A2ProteinHuman-GEM MAR02015Inferred only
- androst-4-ene-3,17-dione is a substrate of SRD5A3ProteinRhea RHEA:50816Inferred only
- androst-4-ene-3,17-dione is a substrate of SRD5A3ProteinHuman-GEM MAR02015Inferred only
- androst-4-ene-3,17-dione is transported by ABCB1ProteinHuman-GEM MAR11757Inferred only
Where it reaches
3 systems, 6 regions, 11 tissues, 11 transporter routes.
Loading the model…
Other names
8 names
Every name this graph resolves to androst-4-ene-3,17-dione. Searching any of them lands here.
- Also called
- 4-ANDROSTENE-3-17-DIONE4-Androstene-3,17-dioneAndrostenedioneDelta(4)-androsten-3,17-dioneDelta(4)-androstene-3,17-dioneST 19:3;O2Δ4-androsten-3,17-dioneΔ4-androstene-3,17-dione