Compound
hypoxanthine
A purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway.
Structure
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- Class
- Organic compound
- Formula
- C5H4N4O
- Mass
- 136.114 g/mol
- Charge
- 0
- InChIKey
- FDGQSTZJBFJUBT-UHFFFAOYSA-N
- SMILES
- O=c1ncnc2ncnc12
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- PNPProteinUNIPROT:P00491substrate ofInferred only108 paths36 endpoints
- XDHProteinUNIPROT:P47989metabolized byInferred only68 paths17 endpoints
- HPRT1ProteinUNIPROT:P00492substrate ofInferred only54 paths27 endpoints
- SLC29A1ProteinUNIPROT:Q99808transported byInferred only43 paths43 endpoints
- SLC43A3ProteinUNIPROT:Q8NBI5transported byInferred only8 paths8 endpoints
- SLC29A2ProteinUNIPROT:Q14542transported byInferred only6 paths3 endpoints
- SLC23A3ProteinUNIPROT:Q6PIS1transported byInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- hypoxanthine has the functional parent adenineCompoundChEBI CHEBI:17368Inferred only
- inosine has the functional parent hypoxanthineCompoundChEBI CHEBI:17596Inferred only
Statements
25 statements
25 statements · 2 reference databases · Subject: hypoxanthine · Sources: Human-GEM, Rhea
- hypoxanthine is converted to adenineCompoundRhea RHEA:23688Inferred only
- adenine is converted to hypoxanthineCompoundRhea RHEA:23688Inferred only
- adenine is converted to hypoxanthineCompoundHuman-GEM MAR09797Inferred only
- xanthine is converted to hypoxanthineCompoundRhea RHEA:68012Inferred only
- hypoxanthine is converted to xanthineCompoundHuman-GEM MAR04519Inferred only
- hypoxanthine is converted to xanthineCompoundHuman-GEM MAR04520Inferred only
- hypoxanthine is converted to xanthineCompoundHuman-GEM MAR08755Inferred only
- hypoxanthine is converted to xanthineCompoundRhea RHEA:24670Inferred only
- hypoxanthine is converted to xanthineCompoundRhea RHEA:68012Inferred only
- xanthine is converted to hypoxanthineCompoundRhea RHEA:24670Inferred only
- hypoxanthine is metabolised by XDHProteinHuman-GEM MAR04519Inferred only
- hypoxanthine is metabolised by XDHProteinHuman-GEM MAR04520Inferred only
Show the remaining 13
- hypoxanthine is metabolised by XDHProteinHuman-GEM MAR08755Inferred only
- hypoxanthine is metabolised by XDHProteinRhea RHEA:24670Inferred only
- hypoxanthine is a substrate of HPRT1ProteinHuman-GEM MAR04418Inferred only
- hypoxanthine is a substrate of HPRT1ProteinRhea RHEA:17973Inferred only
- hypoxanthine is a substrate of PNPProteinHuman-GEM MAR04574Inferred only
- hypoxanthine is a substrate of PNPProteinRhea RHEA:27750Inferred only
- hypoxanthine is a substrate of PNPProteinHuman-GEM MAR04709Inferred only
- hypoxanthine is transported by SLC23A3ProteinRhea RHEA:76279Inferred only
- hypoxanthine is transported by SLC29A1ProteinRhea RHEA:71515Inferred only
- hypoxanthine is transported by SLC29A2ProteinRhea RHEA:71515Inferred only
- hypoxanthine is transported by SLC29A2ProteinHuman-GEM MAR04848Inferred only
- hypoxanthine is transported by SLC29A3ProteinHuman-GEM MAR01463Inferred only
- hypoxanthine is transported by SLC43A3ProteinRhea RHEA:71515Inferred only
Reactions
25 reactions
Transported by SLC29A3
Reaction pageReversibleBalancedlysosome, cytosol
Human-GEM MAR01463CC BY 4.0Reference data
hypoxanthine+5-phospho-alpha-D-ribose 1-diphosphateCHEBI:17202+diphosphate(3-)
Catalysed by HPRT1
Reaction pageLeft to rightBalancedEC 2.4.2.8cytosol
Human-GEM MAR04418CC BY 4.0Reference data
water+hypoxanthine+NAD(+)proton+NADH(2-)+xanthine
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.1.4cytosol
Human-GEM MAR04519CC BY 4.0Reference data
water+hypoxanthine+dioxygenhydrogen peroxide+xanthine
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.3.2cytosol
Human-GEM MAR04520CC BY 4.0Reference data
inosine+phosphate(3-)hypoxanthine+D-ribose 1-phosphate
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1cytosol
Human-GEM MAR04574CC BY 4.0Reference data
MAM00639c+hypoxanthine2'-deoxyinosine+phosphate(3-)
Catalysed by PNP
Reaction pageReversibleBalancedEC 2.4.2.1, 2.4.2.4cytosol
Human-GEM MAR04709CC BY 4.0Reference data
Transported by SLC29A2
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04848CC BY 4.0Reference data
Reaction pageLeft to rightBalancedcytosol, peroxisome
Human-GEM MAR08754CC BY 4.0Reference data
FAD+water+hypoxanthineFADH2+xanthine
Catalysed by XDH
Reaction pageLeft to rightBalancedEC 1.17.3.2peroxisome
Human-GEM MAR08755CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09358CC BY 4.0Reference data
adenine+waterhypoxanthine+ammonium
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR09797CC BY 4.0Reference data
inosine+waterhypoxanthine+D-ribose
Reaction pageDirection not assertedBalanced
Rhea RHEA:16657CC BY 4.0Reference data
Where it reaches
6 systems, 17 regions, 47 tissues, 52 transporter routes — routes, not measurements: transporters known to carry hypoxanthine are expressed there, and no source reports it arriving.
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Other names
7 names
Resolves to: hypoxanthine
- Also called
- 6-oxopurine6(1H)-purinone9H-purin-6(1H)-oneHyppurin-6(1H)-onePurine-6-ol
- Systematic name
- 1,7-dihydro-6H-purin-6-one