Structure
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- Class
- Organic compound, anion
- Formula
- C24H39O5
- Mass
- 407.571 g/mol
- Charge
- -1
- InChIKey
- BHQCQFFYRZLCQQ-OELDTZBJSA-M
- SMILES
- [H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]1([H])C[C@H](O)[C@@]3(C)[C@@]([H])(CC[C@]3([H])[C@H](C)CCC(=O)[O-])[C@]1([H])[C@H](O)C2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
15 entities
15 entities reached.
0 reported hops15 assembled from the scaffold
- CYP7A1ProteinUNIPROT:P22680metabolized byInferred only66 paths33 endpoints
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only53 paths53 endpoints
- HSD17B10ProteinUNIPROT:Q99714substrate ofInferred only33 paths33 endpoints
- SLC27A5ProteinUNIPROT:Q9Y2P5substrate of, transported byInferred only33 paths17 endpoints
- ABCC3ProteinUNIPROT:O15438transported byInferred only33 paths30 endpoints
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- SLC27A2ProteinUNIPROT:O14975substrate ofInferred only22 paths22 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only16 paths8 endpoints
- SLCO1B3ProteinUNIPROT:Q9NPD5transported byInferred only15 paths2 endpoints
- ABCC4ProteinUNIPROT:O15439transported byInferred only10 paths10 endpoints
- ABCB11ProteinUNIPROT:O95342transported byInferred only8 paths3 endpoints
- SLC10A2ProteinUNIPROT:Q12908transported byInferred only4 paths2 endpoints
What the reference databases state
Statements
37 statements
37 statements · 2 reference databases · Subject: cholate · Sources: Human-GEM, Rhea
- cholate is converted to choloyl-CoACompoundRhea RHEA:23532Inferred only
- choloyl-CoA is converted to cholateCompoundRhea RHEA:14541Inferred only
- deoxycholate is converted to cholateCompoundRhea RHEA:16717Inferred only
- cholate is converted to deoxycholateCompoundRhea RHEA:16717Inferred only
- cholate is converted to deoxycholateCompoundHuman-GEM MAR01831Inferred only
- cholate is converted to deoxycholateCompoundHuman-GEM MAR01830Inferred only
- cholate is metabolised by CYP3A4ProteinHuman-GEM MAR12145Inferred only
- cholate is metabolised by CYP7A1ProteinHuman-GEM MAR01831Inferred only
- cholate is metabolised by CYP7A1ProteinHuman-GEM MAR01830Inferred only
- cholate is metabolised by SULT2A1ProteinHuman-GEM MAR12173Inferred only
- cholate is metabolised by UGT2A1ProteinHuman-GEM MAR12168Inferred only
- cholate is metabolised by UGT2A1ProteinHuman-GEM MAR12167Inferred only
Show the remaining 25
- cholate is a substrate of HSD17B10ProteinRhea RHEA:19409Inferred only
- cholate is a substrate of SLC27A2ProteinHuman-GEM MAR01848Inferred only
- cholate is a substrate of SLC27A5ProteinHuman-GEM MAR01848Inferred only
- cholate is a substrate of SLC27A5ProteinRhea RHEA:23532Inferred only
- cholate is transported by ABCB11ProteinHuman-GEM MAR08658Inferred only
- cholate is transported by ABCB11ProteinRhea RHEA:50048Inferred only
- cholate is transported by ABCC3ProteinHuman-GEM MAR08658Inferred only
- cholate is transported by ABCC4ProteinRhea RHEA:66396Inferred only
- cholate is transported by SLC10A1ProteinRhea RHEA:71911Inferred only
- cholate is transported by SLC10A1ProteinHuman-GEM MAR08660Inferred only
- cholate is transported by SLC10A2ProteinHuman-GEM MAR08660Inferred only
- cholate is transported by SLC10A2ProteinRhea RHEA:71911Inferred only
- cholate is transported by SLC27A5ProteinHuman-GEM MAR01665Inferred only
- cholate is transported by SLC46A3ProteinRhea RHEA:75499Inferred only
- cholate is transported by SLCO1A2ProteinHuman-GEM MAR08659Inferred only
- cholate is transported by SLCO1A2ProteinHuman-GEM MAR01875Inferred only
- cholate is transported by SLCO1A2ProteinHuman-GEM MAR01880Inferred only
- cholate is transported by SLCO1A2ProteinHuman-GEM MAR01881Inferred only
- cholate is transported by SLCO1A2ProteinHuman-GEM MAR01882Inferred only
- cholate is transported by SLCO1B1ProteinHuman-GEM MAR08659Inferred only
- cholate is transported by SLCO1B3ProteinHuman-GEM MAR01880Inferred only
- cholate is transported by SLCO1B3ProteinHuman-GEM MAR01882Inferred only
- cholate is transported by SLCO1B3ProteinHuman-GEM MAR08659Inferred only
- cholate is transported by SLCO1B3ProteinHuman-GEM MAR01875Inferred only
- cholate is transported by SLCO1B3ProteinHuman-GEM MAR01881Inferred only
Reactions
47 reactions
CHEBI:15519+watercholate+CHEBI:1146900+proton
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.27cytosol
Human-GEM MAR01660CC BY 4.0Reference data
CHEBI:15519+watercholate+CHEBI:1146900+proton
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.27peroxisome
Human-GEM MAR01663CC BY 4.0Reference data
Transported by SLC27A5
Reaction pageLeft to rightBalancedEC 6.2.1.7peroxisome, cytosol
Human-GEM MAR01665CC BY 4.0Reference data
cholate+water+NADP(3-)deoxycholate+proton+NADPH(4-)+dioxygen
Catalysed by CYP7A1
Reaction pageLeft to rightBalancedEC 1.14.14.23cytosol
Human-GEM MAR01830CC BY 4.0Reference data
cholate+water+NADP(3-)deoxycholate+proton+NADPH(4-)+dioxygen
Catalysed by CYP7A1
Reaction pageLeft to rightBalancedEC 1.14.14.23endoplasmic reticulum
Human-GEM MAR01831CC BY 4.0Reference data
ATP+cholate+CHEBI:1146900AMP+CHEBI:15519+diphosphate(3-)
Catalysed by SLC27A5 or SLC27A2
Reaction pageLeft to rightBalancedEC 6.2.1.7endoplasmic reticulum
Human-GEM MAR01848CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR01850CC BY 4.0Reference data
cholate+CHEBI:16856+hydrogencarbonatecholate+CHEBI:16856+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01875CC BY 4.0Reference data
cholate+MAM01980c+hydrogencarbonatecholate+MAM01980e+hydrogencarbonate
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalance undeterminableextracellular space, cytosol
Human-GEM MAR01880CC BY 4.0Reference data
cholate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathionecholate+hydrogencarbonate+2,4-dinitrophenyl-S-glutathione
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01881CC BY 4.0Reference data
cholate+hydrogencarbonate+MAM02901ccholate+hydrogencarbonate+MAM02901e
Transported by SLCO1A2 or SLCO1B3
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR01882CC BY 4.0Reference data
ATP+cholate+waterADP+cholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08658CC BY 4.0Reference data
Where it reaches
8 systems, 17 regions, 37 tissues, 50 transporter routes — routes, not measurements: transporters known to carry cholate are expressed there, and no source reports it arriving.
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Other names
4 names
Resolves to: cholate
- Also called
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate3α,7α,12α-trihydroxy-5β-cholanate
- Systematic name
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oate3α,7α,12α-trihydroxy-5β-cholan-24-oate