Outcomes — Catalyst

All-cause mortalityEndpointCAT:outcome/all-cause-mortalityrisk ratio · risk — Death from any cause, ascertained over the follow-up horizon each source states. The horizon is recorded with each finding and is not optional:…35 compounds

C-reactive protein concentrationEndpointCAT:outcome/c-reactive-proteinmg/L · concentration — Serum or plasma C-reactive protein (CRP), including high-sensitivity CRP (hs-CRP), by clinical immunoassay. Assay and sensitivity recorded with each…27 compounds

Fasting blood glucoseEndpointCAT:outcome/fasting-blood-glucosemg/dL · concentration — Venous plasma or serum glucose concentration by clinical enzymatic assay in a sample drawn after an overnight fast of stated duration.27 compounds

Total cholesterol (TC)EndpointCAT:outcome/total-cholesterolmg/dL · concentration — Serum or plasma total cholesterol (TC) concentration by clinical enzymatic cholesterol-oxidase assay.27 compounds

LDL cholesterolEndpointCAT:outcome/ldl-cholesterolmg/dL · concentration — Serum or plasma low-density-lipoprotein cholesterol concentration, by direct homogeneous clinical assay or by calculation. The derivation is recorded…26 compounds

TriglyceridesEndpointCAT:outcome/serum-triglyceridesmg/dL · concentration — Serum or plasma triglyceride concentration by clinical enzymatic (glycerol-phosphate-oxidase) assay in a sample drawn after a stated fast. Fast…24 compounds

Interleukin-6 concentrationEndpointCAT:outcome/interleukin-6pg/mL · concentration — Serum or plasma interleukin-6 (IL-6) by immunoassay. Timing relative to exercise recorded with each finding.19 compounds

Systolic blood pressure (setting unspecified)EndpointCAT:outcome/systolic-blood-pressure-unspecified-settingmmHg · pressure — Brachial systolic blood pressure by cuff sphygmomanometry or a validated automated device, where the source does not record the acquisition protocol…23 compounds

Tumour necrosis factor alpha concentrationEndpointCAT:outcome/tnf-alphapg/mL · concentration — Circulating tumour necrosis factor alpha protein concentration in serum or plasma by immunoassay. Timing relative to any exercise bout, meal or…21 compounds

HDL cholesterolEndpointCAT:outcome/hdl-cholesterolmg/dL · concentration — Serum or plasma high-density-lipoprotein cholesterol concentration by direct clinical assay, either a precipitation method or a homogeneous method.…22 compounds

Body massEndpointCAT:outcome/body-masskg · size and mass — Total body mass on a calibrated scale under stated conditions — time of day, fasted or fed, recorded with each finding.22 compounds

Diastolic blood pressure (setting unspecified)EndpointCAT:outcome/diastolic-blood-pressure-unspecified-settingmm Hg · pressure — Brachial diastolic blood pressure by cuff sphygmomanometry or a validated automated device, where the source does not record the acquisition…20 compounds

Alanine aminotransferaseEndpointCAT:outcome/alanine-aminotransferaseU/L · concentration — Serum alanine aminotransferase catalytic activity by clinical enzymatic assay. Whether the reagent was supplemented with pyridoxal phosphate is…19 compounds

HOMA-IREndpointCAT:outcome/homa-irindex · score — Homeostatic model assessment of insulin resistance, computed as fasting insulin multiplied by fasting glucose divided by the model constant — 22.5…23 compounds

Body mass indexEndpointCAT:outcome/body-mass-indexkg/m2 · size and mass — Body mass in kilograms divided by standing height in metres squared, from measured rather than self-reported values, at a stated timepoint.19 compounds

Glycated haemoglobin (HbA1c)EndpointCAT:outcome/hba1c% · proportion — Whole-blood glycated haemoglobin by HPLC, capillary electrophoresis or immunoassay, NGSP/DCCT-aligned. Where a study reports on the IFCC scale in…15 compounds

Aspartate aminotransferaseEndpointCAT:outcome/aspartate-aminotransferaseU/L · concentration — Serum aspartate aminotransferase catalytic activity by clinical enzymatic assay.12 compounds

Total antioxidant capacityEndpointCAT:outcome/total-antioxidant-capacitymmol/L · concentration — Total antioxidant capacity of plasma or serum by a bulk redox colorimetric assay (FRAP, TEAC/ABTS or equivalent), performed on a sample drawn from…14 compounds

Malondialdehyde (circulating)EndpointCAT:outcome/malondialdehyde-circulatingmicromol/L · concentration — Malondialdehyde concentration in plasma, serum or whole blood, by thiobarbituric-acid-reactive-substances colorimetry or by HPLC. The assay is…11 compounds

Flow-mediated dilationEndpointCAT:outcome/flow-mediated-dilationpercent · proportion — Percent increase in brachial artery diameter following release of a cuff occlusion (reactive hyperaemia), by high-resolution B-mode ultrasound. Cuff…9 compounds

Serum 25-hydroxyvitamin D concentrationEndpointCAT:outcome/serum-25-hydroxyvitamin-dnmol/L · concentration — Serum or plasma 25-hydroxyvitamin D concentration by competitive immunoassay or by LC-MS/MS, as the achieved concentration on supplementation. The…1 compound

Hospital length of stayEndpointCAT:outcome/hospital-length-of-staydays · duration — Elapsed time from hospital admission to hospital discharge, taken from the medical record. The reporting unit is recorded with each finding, because…8 compounds

Rating of perceived exertionEndpointCAT:outcome/rating-of-perceived-exertionscore (Borg) · score — Borg-type perceived exertion rating (6 to 20 category scale, or 0 to 10 category-ratio CR10) given during or immediately after a defined exercise…3 compounds

Fat massEndpointCAT:outcome/fat-masskg · size and mass — Adipose tissue mass by dual-energy X-ray absorptiometry, or by a method recorded with each finding where DXA was not used.10 compounds

Plasma nitrite concentrationEndpointCAT:outcome/plasma-nitritenanomol/L · concentration — Plasma or serum nitrite by ozone chemiluminescence or Griess assay, with the assay recorded with each finding.3 compounds

Sleep onset latencyEndpointCAT:outcome/sleep-onset-latencyminutes · duration — Interval from lights-out to the first epoch of persistent sleep, by polysomnography, actigraphy or sleep diary, with the instrument recorded with…2 compounds

Visual analogue scale pain intensityEndpointCAT:outcome/vas-painmm (0-100) · score — Pain intensity marked by the patient on a continuous 0-100 mm or 0-10 cm visual analogue line anchored at no pain and at worst imaginable pain.…9 compounds

Maximal oxygen uptakeEndpointCAT:outcome/vo2maxmL/kg/min · rate and power — Maximal oxygen uptake (VO2max, VO2 peak) by breath-by-breath indirect calorimetry during an incremental exercise test to volitional exhaustion.…9 compounds

Serum creatinine concentrationEndpointCAT:outcome/serum-creatininemg/dL · concentration — Serum or plasma creatinine by clinical assay. Assay method recorded with each finding — Jaffe and enzymatic methods are not interchangeable.6 compounds

Serum leptinEndpointCAT:outcome/serum-leptinng/mL · concentration — Circulating leptin concentration in serum or plasma by immunoassay (ELISA or radioimmunoassay). Species, fasting state and clock time of sampling are…6 compounds

Withdrawal due to adverse eventsEndpointCAT:outcome/withdrawal-due-to-adverse-eventsevent rate · risk — Proportion of randomised participants who permanently discontinued study treatment with an adverse event recorded as the reason for discontinuation,…9 compounds

Intensive care unit length of stayEndpointCAT:outcome/icu-length-of-staydays · duration — Elapsed days from intensive care unit (or paediatric intensive care unit) admission to intensive care unit discharge.8 compounds

Mean arterial pressureEndpointCAT:outcome/mean-arterial-pressuremmHg · pressure — Mean arterial pressure, either computed from a seated cuff systolic and diastolic reading or obtained directly by oscillometric or intra-arterial…5 compounds

Serum adiponectinEndpointCAT:outcome/serum-adiponectinmicrograms/mL · concentration — Circulating adiponectin concentration in serum or plasma by immunoassay (ELISA). Whether the assay measures total adiponectin or the…6 compounds

Serum creatine kinase activityEndpointCAT:outcome/creatine-kinaseU/L · concentration — Serum creatine kinase (CK) activity by clinical assay, used as a marker of exercise-induced muscle damage. Time since the damaging bout recorded with…9 compounds

Superoxide dismutase activityEndpointCAT:outcome/superoxide-dismutase-activityU/mL · concentration — Superoxide dismutase enzymatic activity in erythrocyte lysate, whole blood or serum, by inhibition-of-substrate-oxidation assay, expressed per gram…6 compounds

Total sleep timeEndpointCAT:outcome/total-sleep-timeminutes · duration — Total time scored as sleep across a recording period, by polysomnography, actigraphy or sleep diary, with the instrument recorded with each finding.3 compounds

Necrotising enterocolitis incidenceEndpointCAT:outcome/necrotising-enterocolitis-incidencerisk ratio · risk — Proportion of infants developing necrotising enterocolitis, staged by the modified Bell criteria. The stage counted as an event is recorded with each…6 compounds

Plasma nitrate concentrationEndpointCAT:outcome/plasma-nitratemicromol/L · concentration — Plasma or serum nitrate by ozone chemiluminescence, Griess assay or HPLC, with the assay recorded with each finding.2 compounds

Time to exhaustionEndpointCAT:outcome/time-to-exhaustions · duration — Duration sustained at a fixed submaximal workload until volitional failure. Workload and modality recorded with each finding.7 compounds

Total testosteroneEndpointCAT:outcome/total-testosteronenmol/L · concentration — Serum or plasma total testosterone concentration by liquid chromatography with tandem mass-spectrometry or by immunoassay, in a sample drawn at a…7 compounds

Adverse event occurrence (oral or enteral supplement)EndpointCAT:outcome/supplement-adverse-event-incidencerisk ratio · risk — Occurrence of any adverse event in a trial of an orally or enterally administered supplement — gastrointestinal upset, elevated liver enzymes,…7 compounds

Countermovement jump heightEndpointCAT:outcome/countermovement-jump-heightcm · size and mass — Vertical displacement of the centre of mass in a countermovement jump, by force platform, contact mat, or optical system. The apparatus is recorded…4 compounds

Peak power outputEndpointCAT:outcome/peak-power-outputW · rate and power — Highest mechanical power in a single maximal effort, cycle ergometer, typically the first five seconds of a 30-second Wingate test.4 compounds

Preterm birth incidenceEndpointCAT:outcome/preterm-birth-incidencerisk ratio or odds ratio · risk — Incidence of preterm birth, delivery before 37 completed weeks of gestation, ascertained from the delivery record. The population is recorded with…4 compounds

Prostate cancer incidenceEndpointCAT:outcome/prostate-cancer-incidencerisk ratio · risk — Incident histologically confirmed prostate cancer diagnoses over the follow-up the source states.6 compounds

Time-trial completion timeEndpointCAT:outcome/time-trial-performances · duration — Time to complete a self-paced fixed-DISTANCE trial. Distance and modality recorded with each finding.3 compounds

Glutathione peroxidase activityEndpointCAT:outcome/glutathione-peroxidase-activityU/L · concentration — Glutathione peroxidase enzymatic activity in erythrocyte lysate, whole blood, plasma or serum, by coupled glutathione-reductase assay following NADPH…5 compounds

Infectious complication rateEndpointCAT:outcome/infectious-complication-rateevent rate · risk — Proportion of patients developing an infectious complication as defined by each source's own criteria. The case definition and the clinical setting…2 compounds

Lean body massEndpointCAT:outcome/lean-masskg · size and mass — Fat-free soft tissue mass (FFM) by dual-energy X-ray absorptiometry, or by a method recorded with each finding where DXA was not used.5 compounds

Organism lifespanEndpointCAT:outcome/organism-lifespanhazard ratio · risk — Elapsed time from the start of observation until death in a model organism, read from a survival curve as median or maximum lifespan, or as the…4 compounds

Serious adverse event incidenceEndpointCAT:outcome/serious-adverse-event-incidenceevent rate · risk — Proportion of participants experiencing at least one event meeting the trial protocol regulatory seriousness criteria (death, life-threatening event,…6 compounds

Birth weightEndpointCAT:outcome/birth-weightgrams · size and mass — Weight of the infant recorded at birth, in grams, from the delivery or neonatal record.5 compounds

Clinical pregnancy rateEndpointCAT:outcome/clinical-pregnancy-raterisk ratio · risk — Proportion of participants or treatment cycles with an ultrasound-confirmed intrauterine gestational sac, typically at 6 to 7 weeks. The denominator…4 compounds

Duration of mechanical ventilationEndpointCAT:outcome/mechanical-ventilation-durationdays · duration — Elapsed time from initiation of invasive mechanical ventilation to successful extubation without reintubation within the trial stated window,…5 compounds

Hamilton Depression Rating Scale (HDRS) total scoreEndpointCAT:outcome/hdrs-total-scorepoints · score — Total score on the clinician-administered Hamilton Depression Rating Scale (HDRS / HAM-D), summed across its items into a single continuous…5 compounds

Incidence of strokeEndpointCAT:outcome/stroke-incidencerelative risk · risk — Incident stroke events ascertained by each source's stated adjudication criteria. Ischaemic and haemorrhagic subtypes are recorded with each finding…5 compounds

Isometric peak forceEndpointCAT:outcome/isometric-peak-forceN · rate and power — Peak force during a maximal voluntary isometric contraction against an immovable resistance. Joint angle and apparatus recorded with each finding.3 compounds

Mean power outputEndpointCAT:outcome/mean-power-outputW · rate and power — Average mechanical power sustained across a fixed-duration maximal effort, cycle ergometer, duration recorded with each finding.3 compounds

Serum alkaline phosphataseEndpointCAT:outcome/alkaline-phosphataseU/L · concentration — Serum alkaline phosphatase catalytic activity by clinical para-nitrophenyl-phosphate assay at a stated temperature.2 compounds

Serum magnesium concentrationEndpointCAT:outcome/serum-magnesiummg/dL · concentration — Magnesium concentration in serum, plasma, or whole blood by clinical colorimetric assay (calmagite or xylidyl blue) or by atomic absorption…1 compound

Total leukocyte countEndpointCAT:outcome/leukocyte-countx10^9/L · concentration — Total white blood cell count in peripheral blood from an automated full blood count analyser. The reported unit is recorded with each finding —…4 compounds

Upper-body muscular strength (pooled composite)EndpointCAT:outcome/upper-body-strength-compositestandardised mean difference (SMD) · pooled effect size — Meta-analytic aggregate of upper-body strength across whichever tests the primary trials used — chest press, bench press, elbow flexion, lat pulldown…2 compounds

Cardiovascular mortalityEndpointCAT:outcome/cardiovascular-mortalityhazard ratio · risk — Death with cardiovascular disease as the adjudicated or registry-recorded underlying cause, over the source's follow-up. The adjudication source and…3 compounds

Catalase activityEndpointCAT:outcome/catalase-activityU/mL · concentration — Catalase enzymatic activity in erythrocyte lysate, whole blood or serum, by rate of hydrogen peroxide decomposition followed spectrophotometrically…4 compounds

Colorectal cancer incidenceEndpointCAT:outcome/colorectal-cancer-incidencerisk ratio · risk — Incident colon or rectal cancer diagnoses over the follow-up the source states.4 compounds

Erythrocyte sedimentation rateEndpointCAT:outcome/erythrocyte-sedimentation-ratemm/h · rate and power — Erythrocyte sedimentation rate by the Westergren method — the distance red cells fall through an anticoagulated whole-blood column in one hour.…4 compounds

Gastric cancer incidenceEndpointCAT:outcome/gastric-cancer-incidencerisk ratio · risk — Incident gastric (stomach) cancer diagnoses ascertained by cancer registry linkage, pathology report, or medical record review. Cardia and non-cardia…3 compounds

Health-related quality of lifeEndpointCAT:outcome/health-related-quality-of-lifescore · score — Patient-reported health-related quality of life score on whichever validated multi-domain instrument the source administered (SF-36, EQ-5D, WHOQOL,…3 compounds

Incidence of cardiovascular disease (composite)EndpointCAT:outcome/cardiovascular-disease-incidence-compositerelative risk · risk — Composite incident cardiovascular events as defined by each source study. The component set is recorded with each finding and is never assumed.4 compounds

Lower-body muscular strength (pooled composite)EndpointCAT:outcome/lower-body-strength-compositestandardised mean difference (SMD) · pooled effect size — Meta-analytic aggregate of lower-limb strength across whichever tests the primary trials used — back squat, leg press, knee extension, isokinetic…2 compounds

Muscle strength (pooled across mixed instruments)EndpointCAT:outcome/muscle-strength-pooledstandardised mean difference · pooled effect size — Standardised mean difference or Hedges g for muscular strength, pooled across whatever strength tests the constituent trials happened to use, with no…3 compounds

Pittsburgh Sleep Quality Index global scoreEndpointCAT:outcome/psqi-global-scorescore (0-21) · score — Global score of the Pittsburgh Sleep Quality Index, a 19-item self-report questionnaire covering the past month, summed from seven component domains…4 compounds

Reduced glutathione concentrationEndpointCAT:outcome/reduced-glutathionemicromol/L · concentration — Reduced glutathione concentration in erythrocytes, whole blood or plasma, by enzymatic recycling assay or by chromatography with the method recorded…4 compounds

Repeated-sprint performance decrementEndpointCAT:outcome/repeated-sprint-decrementpercent · proportion — Decline in output across successive maximal sprints within one bout, expressed as a percentage decrement or fatigue index. Sprint count and recovery…3 compounds

Serum albuminEndpointCAT:outcome/serum-albuming/dL · concentration — Serum albumin concentration by clinical colorimetric dye-binding assay. The dye is recorded with each finding, because bromocresol green reads…4 compounds

Subjective fatigueEndpointCAT:outcome/subjective-fatigueinstrument-specific score · score — Score on a named validated self-report instrument measuring FATIGUE specifically. Instrument recorded with each finding.4 compounds

Working memory performanceEndpointCAT:outcome/working-memoryinstrument-specific score · score — Score on a named validated instrument. The instrument is recorded with each finding and is part of what makes two findings comparable.4 compounds

Wound infection incidenceEndpointCAT:outcome/wound-infection-incidencerisk ratio · risk — Proportion of patients developing a clinically or microbiologically diagnosed infection at the burn wound, surgical wound, or graft site, per the…2 compounds

Antidepressant treatment response rateEndpointCAT:outcome/antidepressant-response-raterisk ratio · risk — Proportion of patients meeting a protocol-defined response criterion on a depression rating scale, conventionally at least a 50% reduction from…3 compounds

Anxiety symptom severity (pooled across unnamed instruments)EndpointCAT:outcome/anxiety-symptom-severity-pooledstandardised mean difference (SMD) · pooled effect size — Standardised mean difference in anxiety symptom severity pooled across whichever self-report or clinician-rated instruments the primary trials used,…3 compounds

Blood haemoglobin concentrationEndpointCAT:outcome/blood-haemoglobing/L · concentration — Haemoglobin concentration in whole blood by automated haematology analyser. Sample site and posture recorded with each finding — capillary samples…3 compounds

Body weight gain over a feeding or growth periodEndpointCAT:outcome/body-weight-gaing · size and mass — Increase in whole-body mass of an animal between the start and end of a stated feeding or growth period, final mass minus initial mass on a…2 compounds

Cortisol concentrationEndpointCAT:outcome/serum-cortisolmicrograms/dL · concentration — Cortisol concentration in serum, plasma or saliva by immunoassay or LC-MS/MS. The matrix, the clock time of sampling, and whether the value is a…3 compounds

Expanded Disability Status Scale (EDSS)EndpointCAT:outcome/edssscore (0-10) · score — Expanded Disability Status Scale, rated by a neurologist from the standard neurological examination and functional system scores, from 0 to 10 in…3 compounds

Gestational diabetes mellitus incidenceEndpointCAT:outcome/gestational-diabetes-incidenceproportion · risk — Proportion of pregnant women with a new diagnosis of gestational diabetes mellitus, made by oral glucose tolerance test (typically 24-28 weeks of…2 compounds

HaematocritEndpointCAT:outcome/haematocritpercent · proportion — Packed red cell volume as a fraction of whole blood, by automated haematology analyser (calculated from red cell count and mean corpuscular volume)…3 compounds

Incidence of coronary heart diseaseEndpointCAT:outcome/coronary-heart-disease-incidencerelative risk · risk — Incident coronary heart disease events — fatal and non-fatal coronary events including angina and coronary revascularisation — over the follow-up the…3 compounds

Lumbar spine bone mineral densityEndpointCAT:outcome/lumbar-spine-bmdg/cm^2 · size and mass — Areal bone mineral density of the lumbar spine, typically L1-L4 or L2-L4, by dual-energy X-ray absorptiometry. The vertebral levels included, the…3 compounds

Macular pigment optical densityEndpointCAT:outcome/macular-pigment-optical-densityoptical density units · score — Macular pigment optical density by heterochromatic flicker photometry, fundus autofluorescence or reflectometry, at the retinal eccentricity the…1 compound

Mini-Mental State Examination total scoreEndpointCAT:outcome/mmse-total-scorepoints (0-30) · score — Global cognitive screening score on the Mini-Mental State Examination, 0 to 30, administered by a trained assessor. Where a study reports a modified…3 compounds

One-repetition maximum strengthEndpointCAT:outcome/1rm-strengthkg · size and mass — Maximal single repetition, standardised lift, tested to failure under a documented warm-up and progression protocol.2 compounds

Peak postprandial blood glucoseEndpointCAT:outcome/peak-postprandial-glucosemmol/L · concentration — Highest blood glucose concentration recorded during serial sampling after a fixed mixed-nutrient drink or oral glucose load.3 compounds

Radiographic joint-space narrowingEndpointCAT:outcome/radiographic-joint-space-narrowingmm · size and mass — Reduction over a stated interval in the minimum radiographic distance between the femoral and tibial articular surfaces on standardised…2 compounds

Serum uric acidEndpointCAT:outcome/serum-uric-acidmg/dL · concentration — Serum or plasma uric acid concentration by clinical uricase enzymatic assay.3 compounds

Activities of daily living scoreEndpointCAT:outcome/activities-of-daily-living-scorescore · score — Score on a validated basic activities of daily living scale (Barthel Index, Katz ADL, or equivalent) rating independence in self-care tasks such as…2 compounds

Acute kidney injury incidence (any grade)EndpointCAT:outcome/acute-kidney-injury-incidenceproportion · risk — Proportion of patients developing acute kidney injury of any severity grade, staged by a named clinical criteria set (KDIGO, AKIN, RIFLE, or CTCAE).…2 compounds

Adverse reaction incidence (unstandardised)EndpointCAT:outcome/adverse-reaction-incidence-ungradedevent rate · risk — Proportion of participants for whom investigators recorded at least one adverse reaction attributed to the study product, tallied by each trial's own…2 compounds

Beck Depression Inventory (BDI) total scoreEndpointCAT:outcome/bdi-total-scorepoints (0-63) · score — Total score on the self-report Beck Depression Inventory (BDI or BDI-II), summed across its items into a single continuous depression-severity score.2 compounds

Breast cancer incidenceEndpointCAT:outcome/breast-cancer-incidenceproportion · risk — Incident breast cancer diagnoses ascertained by cancer registry linkage, pathology report, or medical record review.2 compounds

CD4/CD8 ratioEndpointCAT:outcome/cd4-cd8-ratioratio (dimensionless) · proportion — Ratio of CD4+ to CD8+ T lymphocytes in peripheral blood from a single flow cytometry panel, computed either from the subset percentages or from the…2 compounds

Circulating coenzyme Q10 concentrationEndpointCAT:outcome/circulating-coenzyme-q10micrograms/mL · concentration — Plasma or serum total coenzyme Q10 concentration by high-performance liquid chromatography with electrochemical or ultraviolet detection. Any lipid…1 compound

Clinical attachment level (CAL) gainEndpointCAT:outcome/clinical-attachment-level-gainmm · size and mass — Change from baseline in the distance from the cemento-enamel junction to the base of the periodontal sulcus, measured with a manual or…1 compound

Delayed-onset muscle sorenessEndpointCAT:outcome/muscle-sorenessinstrument-specific score · score — Perceived soreness on a named validated scale — visual analogue scale (VAS) or Likert — at a stated interval after a damaging bout. Instrument and…2 compounds

Diastolic blood pressure (office/clinic)EndpointCAT:outcome/office-diastolic-blood-pressuremmHg · pressure — Diastolic blood pressure taken at a clinic visit with the participant seated after a stated rest period, by auscultatory or validated automated cuff…2 compounds

Gamma-glutamyl transferaseEndpointCAT:outcome/gamma-glutamyl-transferaseIU/L · concentration — Serum gamma-glutamyl transferase catalytic activity by clinical enzymatic assay, reported in international units per litre. The assay temperature and…2 compounds

Gestational age at delivery (length of gestation)EndpointCAT:outcome/gestational-age-at-birthweeks · duration — Duration of pregnancy from the last menstrual period or best obstetric estimate to delivery, in completed weeks, from the delivery or neonatal record.2 compounds

Incidence of ICU deliriumEndpointCAT:outcome/icu-delirium-incidenceevent rate · risk — New-onset delirium during intensive care admission, diagnosed by a bedside screening instrument (CAM-ICU, ICDSC or equivalent) applied on a stated…1 compound

Incidence of postoperative deliriumEndpointCAT:outcome/postoperative-delirium-incidenceevent rate · risk — New-onset delirium during the postoperative period in adult surgical patients, diagnosed by a validated assessment (Confusion Assessment Method, DSM…2 compounds

Mean arterial pressure in vasodilatory shockEndpointCAT:outcome/mean-arterial-pressure-in-vasodilatory-shockmmHg · pressure — Mean arterial pressure, usually written MAP, by intra-arterial line or oscillometric monitoring, wherever RAISING it to a haemodynamic target is the…1 compound

Metabolic syndrome (presence)EndpointCAT:outcome/metabolic-syndrome-presenceodds ratio · risk — Presence of the metabolic syndrome by a stated diagnostic criteria set (ATP III, IDF, or the harmonised definition). The criteria set is recorded…1 compound

Nocturnal voiding frequency (nocturia)EndpointCAT:outcome/nocturnal-voiding-frequencyvoids per night · rate and power — Number of nocturnal voids per night, counted from a voiding diary or patient report over a stated number of nights.1 compound

Numeric rating scale (NRS) pain intensityEndpointCAT:outcome/nrs-painpoints (0-10 numeric rating scale, or the equivalent 0-100 rescaling in 10-point steps as recorded with each finding) · score — Pain intensity stated by the patient as a whole number on an 11-point numeric rating scale anchored at no pain and worst imaginable pain, most…2 compounds

Oesophageal cancer incidenceEndpointCAT:outcome/oesophageal-cancer-incidencerisk ratio · risk — Incident oesophageal cancer diagnoses over the follow-up the source states.2 compounds

Osteoarthritis pain (pooled across scales)EndpointCAT:outcome/osteoarthritis-pain-pooledstandardised mean difference · pooled effect size — Standardised mean difference for osteoarthritis pain pooled across whichever pain instrument each constituent trial used, the mixture of instruments…1 compound

Pancreatic cancer incidenceEndpointCAT:outcome/pancreatic-cancer-incidencerisk ratio · risk — Incident pancreatic cancer diagnoses ascertained by cancer registry linkage, pathology report, or medical record review.2 compounds

Physical function (pooled across scales)EndpointCAT:outcome/physical-function-pooledstandardised mean difference · pooled effect size — Standardised mean difference for physical function pooled across trials, the source instrument not held constant. The sign convention of the pooled…2 compounds

Plasma glucagon-like peptide-1 (GLP-1)EndpointCAT:outcome/plasma-glp-1pmol/L · concentration — Plasma glucagon-like peptide-1 by immunoassay from serial postprandial sampling after a fixed mixed-nutrient drink or during intraduodenal nutrient…2 compounds

Plasma/serum 5-hydroxytryptophan concentrationEndpointCAT:outcome/plasma-5-hydroxytryptophanng/mL · concentration — 5-hydroxytryptophan concentration in serum or platelet-poor plasma by chromatographic assay (HPLC with electrochemical detection, or LC-MS/MS). Where…1 compound

Postprandial energy expenditure (ventilated hood indirect calorimetry)EndpointCAT:outcome/postprandial-energy-expenditure-ventilated-hoodkilocalories — Whole-body energy expenditure after a test meal, calculated from oxygen consumption and carbon dioxide production measured by ventilated-hood…1 compound

Pre-eclampsia incidenceEndpointCAT:outcome/pre-eclampsia-incidenceproportion · risk — Proportion of pregnant women with a new diagnosis of pre-eclampsia, defined as new-onset hypertension after 20 weeks of gestation together with…1 compound

Retinopathy of prematurity incidenceEndpointCAT:outcome/retinopathy-of-prematurity-incidencerisk ratio · risk — Proportion of infants developing retinopathy of prematurity, by screening ophthalmoscopy against the International Classification. The stage…2 compounds

Rey Auditory Verbal Learning Test delayed recall scoreEndpointCAT:outcome/avlt-delayed-recallwords recalled (count) · count — Number of words correctly recalled on the delayed free-recall trial of the Rey Auditory Verbal Learning Test (AVLT), administered after the standard…2 compounds

Seizure frequency 50% responder rateEndpointCAT:outcome/seizure-frequency-50-percent-responder-rateproportion · risk — Proportion of epilepsy patients whose seizure frequency, counted from a seizure diary over a stated baseline period and a stated treatment period,…1 compound

Serum or plasma lutein concentrationEndpointCAT:outcome/serum-lutein-concentrationmicromol/L · concentration — Lutein concentration in serum or plasma by high-performance liquid chromatography, fasting state and matrix recorded with each finding. Where a study…1 compound

Serum prostate-specific antigenEndpointCAT:outcome/prostate-specific-antigenng/mL · concentration — Total prostate-specific antigen concentration in serum by clinical immunoassay. The assay platform, and whether the value is total, free, or a…2 compounds

Squat jump heightEndpointCAT:outcome/squat-jump-heightcm · size and mass — Vertical jump height from a held static squat position, initiated without a preparatory dip, by force platform or contact mat.1 compound

Systemic vascular resistanceEndpointCAT:outcome/systemic-vascular-resistancedyn.s/cm^5 · pressure — Systemic vascular resistance calculated from the standard haemodynamic formula using invasively or non-invasively measured perfusion pressures and…2 compounds

Type 2 diabetes incidenceEndpointCAT:outcome/type-2-diabetes-incidenceproportion · risk — Incident type 2 diabetes mellitus diagnoses, ascertained by clinical diagnosis, registry linkage, or a stated glycaemic diagnostic criterion, in a…2 compounds

Urinary bladder cancer incidenceEndpointCAT:outcome/urinary-bladder-cancer-incidencerisk ratio · risk — Incident urinary bladder cancer diagnoses ascertained by cancer registry linkage, pathology report, or medical record review.2 compounds

Vertebral fracture incidenceEndpointCAT:outcome/vertebral-fracture-incidenceproportion · risk — Proportion of participants with at least one new fracture of a vertebral body, ascertained by semi-quantitative or morphometric reading of spinal…1 compound

Waist circumferenceEndpointCAT:outcome/waist-circumferencecm · size and mass — Girth of the waist by tape measure at the landmark the source protocol states (midpoint between lowest rib and iliac crest, umbilical level or…2 compounds

Waist-to-hip ratioEndpointCAT:outcome/waist-to-hip-ratioindex · score — Waist girth divided by hip girth from tape anthropometry at the landmarks stated by the source protocol - WHO specifies the waist at the midpoint…2 compounds

24-hour ambulatory systolic blood pressureEndpointCAT:outcome/ambulatory-systolic-bp-24hmmHg · pressure — Mean systolic pressure across a 24-hour ambulatory blood pressure monitoring recording, from an automated oscillometric device taking readings at…1 compound

Ad libitum test-meal energy intakeEndpointCAT:outcome/ad-libitum-test-meal-energy-intakekcal — Total energy content of food voluntarily consumed during a laboratory ad libitum test meal offered after a preceding standardized meal, drink, or…1 compound

Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scoreEndpointCAT:outcome/adas-cog-scorescore (0-70) · score — Total score on the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), administered by a trained rater.1 compound

Arginine-to-ornithine ratioEndpointCAT:outcome/arginine-ornithine-ratioratio · proportion — Ratio of plasma arginine concentration to plasma ornithine concentration measured on the same specimen, used to index arginase-mediated diversion of…1 compound

Asymmetric dimethylarginine (ADMA) concentrationEndpointCAT:outcome/admaumol/L · concentration — Circulating asymmetric dimethylarginine in plasma or serum by HPLC, LC-MS/MS or ELISA. Assay platform recorded with each finding — ELISA and…1 compound

Bleeding on probingEndpointCAT:outcome/bleeding-on-probingpercent of sites · proportion — Percentage of examined periodontal sites that bleed within the stated interval, usually 15 to 30 seconds, after gentle probing with a calibrated…1 compound

Blood urea nitrogenEndpointCAT:outcome/blood-urea-nitrogenmg/dL · concentration — Serum urea nitrogen concentration by clinical assay, reported on the nitrogen scale.1 compound

Carotid-femoral pulse wave velocityEndpointCAT:outcome/carotid-femoral-pulse-wave-velocitym/s · rate and power — Aortic pulse wave velocity derived from the carotid-to-femoral transit time and the surface path length between those two recording sites, by…1 compound

CD4+ T cell countEndpointCAT:outcome/cd4-t-cell-countcells/uL · concentration — Absolute count of CD4-positive T lymphocytes per unit volume of peripheral blood by flow cytometry.1 compound

Choice reaction timeEndpointCAT:outcome/choice-reaction-timemilliseconds · duration — Latency from stimulus onset to a correct response in a computerised multiple-alternative reaction time task from a validated cognitive battery (CDR /…1 compound

Colorectal adenoma recurrence after polypectomyEndpointCAT:outcome/colorectal-adenoma-recurrenceproportion · risk — Recurrence of colorectal adenoma detected at surveillance colonoscopy following prior polypectomy, ascertained at the protocol's stated follow-up…1 compound

Community-dwelling atrial fibrillation incidenceEndpointCAT:outcome/community-atrial-fibrillation-incidenceproportion · risk — Incident atrial fibrillation, new-onset or first-diagnosed, in community-dwelling general-population adults free of atrial fibrillation at baseline,…1 compound

Congenital cardiovascular malformation incidence (offspring)EndpointCAT:outcome/congenital-cardiovascular-malformation-incidenceproportion · risk — Proportion of live-born infants with a diagnosed congenital cardiovascular malformation, including atrial or ventricular septal defects, ascertained…1 compound

Cortical cataract incidenceEndpointCAT:outcome/cortical-cataract-incidencerelative risk · risk — Incident cortical age-related lens opacity by standardised slit-lamp lens grading or documented clinical diagnosis.1 compound

Diarrhoea durationEndpointCAT:outcome/diarrhoea-durationdays · duration — Elapsed time from onset of a diarrhoeal episode to its resolution by the study's stated stool-consistency or frequency criterion, from a participant…1 compound

Disease Activity Score in 28 joints (DAS-28)EndpointCAT:outcome/das-28score · score — Disease Activity Score in 28 joints: a weighted composite of the 28-joint tender count, the 28-joint swollen count, an acute-phase reactant, and the…1 compound

Erythrocyte glutathione reductase activation coefficient (EGRac)EndpointCAT:outcome/egrac-riboflavin-statusactivation coefficient (dimensionless ratio) · proportion — Erythrocyte glutathione reductase activation coefficient (EGRac), a functional biomarker of riboflavin (vitamin B2) status computed as the ratio of…1 compound

Estimated glomerular filtration rateEndpointCAT:outcome/egfrmL/min/1.73m2 · rate and power — eGFR from a stated estimating equation. The equation is recorded with each finding, and creatinine-based equations are flagged as such.1 compound

Femoral neck bone mineral densityEndpointCAT:outcome/femoral-neck-bmdg/cm2 · size and mass — Areal bone mineral density of the femoral neck region of interest by dual-energy X-ray absorptiometry, in grams per square centimetre. Scanner…1 compound

Forced expiratory volume in one second (FEV1)EndpointCAT:outcome/fev1litres (or percent of predicted normal value, recorded with each finding) · proportion — Volume of air forcefully exhaled during the first second of a forced vital capacity manoeuvre, by spirometry. Baseline airway status (e.g. asthma…1 compound

Gastric emptying rateEndpointCAT:outcome/gastric-emptying-rateminutes (half-emptying time, T1/2) · duration — Emptying of a standardised test meal or drink from the stomach, by 13C-acetate or 13C-octanoate breath test, gamma scintigraphy, or paracetamol…1 compound

Gestational hypertension incidenceEndpointCAT:outcome/gestational-hypertension-incidenceproportion · risk — Proportion of pregnant women with a new diagnosis of gestational hypertension, defined as blood pressure of 140/90 mmHg or above first arising after…1 compound

Handgrip strength (hand dynamometer)EndpointCAT:outcome/handgrip-strengthkg · size and mass — Maximal voluntary isometric contraction force of hand grip, by hand dynamometer, reported as the absolute value or normalised to body weight.1 compound

Helicobacter pylori eradication rateEndpointCAT:outcome/h-pylori-eradication-rateproportion (pooled as absolute risk difference or odds ratio) · risk — Proportion of treated patients confirmed free of Helicobacter pylori infection on post-treatment testing (urea breath test, stool antigen test, or…1 compound

Hip fracture incidenceEndpointCAT:outcome/hip-fracture-incidenceproportion · risk — Proportion of participants sustaining at least one incident fracture of the proximal femur (femoral neck or trochanteric region), ascertained by…1 compound

Hippocampal CA1 long-term potentiation magnitudeEndpointCAT:outcome/hippocampal-ca1-ltp-magnitude% of baseline · proportion — Magnitude of long-term potentiation at CA1 synapses of Schaffer collateral input in acute hippocampal slices, as field excitatory postsynaptic…1 compound

Incidence of myocardial infarctionEndpointCAT:outcome/myocardial-infarction-incidencehazard ratio · risk — Adjudicated myocardial infarction events during follow-up, ascertained by an endpoint committee against a universal-definition or study-specific…1 compound

Intraventricular haemorrhage incidenceEndpointCAT:outcome/intraventricular-haemorrhage-incidencerisk ratio · risk — Proportion of infants with intraventricular haemorrhage on cranial ultrasound, graded by the Papile classification. The grade counted as an event is…1 compound

Knee injury and Osteoarthritis Outcome Score (KOOS)EndpointCAT:outcome/koos-total-scorepoints (0-100) · score — Patient-reported knee status on the KOOS instrument, scored 0 to 100 where 100 is no knee problem. The instrument defines five subscales and papers…1 compound

Lung cancer incidenceEndpointCAT:outcome/lung-cancer-incidencerisk ratio · risk — Incident lung cancer diagnoses over the follow-up the source states.1 compound

Matsuda insulin sensitivity indexEndpointCAT:outcome/matsuda-indexindex (arbitrary units) · score — Matsuda index of whole-body insulin sensitivity, computed as 10000 divided by the square root of the product of fasting glucose, fasting insulin,…1 compound

Maximum urinary flow rate (Qmax, peak flow)EndpointCAT:outcome/maximum-urinary-flow-ratemL/s · rate and power — Peak urinary flow rate by uroflowmetry, on a void exceeding the study's stated minimum voided volume. The minimum voided volume is recorded with each…1 compound

Melanoma incidenceEndpointCAT:outcome/melanoma-incidenceproportion · risk — Incident cutaneous melanoma diagnoses ascertained by cancer registry linkage, pathology report, or medical record review.1 compound

Mitral E/e' ratioEndpointCAT:outcome/mitral-e-to-e-prime-ratioratio · proportion — Ratio of early diastolic mitral inflow velocity (E) to early diastolic mitral annular tissue Doppler velocity (e') by transthoracic echocardiography,…1 compound

Natural killer cell activityEndpointCAT:outcome/natural-killer-cell-activitypercent cytotoxicity · proportion — Cytotoxic activity of peripheral blood natural killer cells against a standard target cell line, typically K562, by chromium-51 release,…1 compound

Nuclear cataract incidenceEndpointCAT:outcome/nuclear-cataract-incidencerelative risk · risk — Incident nuclear age-related lens opacity by standardised slit-lamp lens grading (LOCS-type) or documented clinical diagnosis.1 compound

Ovarian cancer incidenceEndpointCAT:outcome/ovarian-cancer-incidenceproportion · risk — Incident ovarian cancer (ovarian carcinoma) diagnoses ascertained by cancer registry linkage, pathology report, self-report with confirmation, or…1 compound

Overall exercise performance (pooled composite)EndpointCAT:outcome/pooled-exercise-performance-compositestandardised mean difference (Hedges g) · pooled effect size — Multi-level pooled standardised effect (Hedges g or standardised mean difference) computed across whatever exercise tests the primary trials used -…1 compound

Parkinson's disease incidenceEndpointCAT:outcome/parkinsons-disease-incidenceproportion · risk — Incident Parkinson's disease diagnosis in a population, ascertained by clinical diagnosis or registry-based ascertainment criteria.1 compound

Perceived Stress Scale (PSS) scoreEndpointCAT:outcome/perceived-stress-scalescore (points) · score — Cohen Perceived Stress Scale total score (PSS-14, PSS-10, or PSS-4), self-completed, appraising the uncontrollability and unpredictability of life…1 compound

Plasma citrulline concentrationEndpointCAT:outcome/plasma-citrulline-concentrationumol/L · concentration — Concentration of citrulline in plasma or serum by amino acid analyser, HPLC or LC-MS/MS, used as a marker of enterocyte mass or of citrulline…1 compound

Posterior subcapsular cataract incidenceEndpointCAT:outcome/posterior-subcapsular-cataract-incidencerelative risk · risk — Incident posterior subcapsular age-related lens opacity by standardised slit-lamp lens grading or documented clinical diagnosis.1 compound

Postoperative atrial fibrillation incidenceEndpointCAT:outcome/postoperative-atrial-fibrillation-incidenceproportion · risk — Proportion of surgical patients developing new-onset atrial fibrillation during the postoperative period, ascertained by continuous cardiac…1 compound

Postprandial blood glucose area under the curveEndpointCAT:outcome/postprandial-glucose-aucmmol/L x min · concentration — Incremental area under the blood glucose concentration-time curve over 60 to 120 minutes following a fixed mixed-nutrient drink or oral glucose load,…1 compound

Psoriasis Area and Severity Index (PASI) scoreEndpointCAT:outcome/pasi-scorepoints (0-72 scale), or percent change from baseline as recorded with each finding · score — Psoriasis Area and Severity Index (PASI), a clinician-scored composite of psoriasis extent and severity across four body regions ranging 0 to 72,…1 compound

Pulse wave velocity (segment unspecified)EndpointCAT:outcome/pulse-wave-velocity-unspecified-segmentm/s · rate and power — Arterial pulse wave velocity computed as the distance between two arterial recording sites divided by the pulse transit time between them, where the…1 compound

Repetitions to failure at a fixed relative loadEndpointCAT:outcome/repetitions-to-failure-fixed-loadrepetitions · count — Number of repetitions completed to volitional muscular failure in a resistance-exercise set performed at a fixed percentage of one-repetition…1 compound

Sequential Organ Failure Assessment (SOFA) total scoreEndpointCAT:outcome/sofa-total-scorepoints · score — Total score on the Sequential Organ Failure Assessment, summing six organ-system subscores (respiration, coagulation, liver, cardiovascular, central…1 compound

Serum free thyroxine (FT4)EndpointCAT:outcome/serum-free-thyroxinepmol/L · concentration — Free (unbound) thyroxine concentration in serum or plasma by clinical immunoassay, in pmol/L (or ng/dL as reported). The assay platform and unit are…1 compound

Serum free triiodothyronine (FT3)EndpointCAT:outcome/serum-free-triiodothyroninepmol/L · concentration — Free (unbound) triiodothyronine concentration in serum or plasma by clinical immunoassay, in pmol/L (or pg/mL as reported). The assay platform and…1 compound

Serum potassium concentrationEndpointCAT:outcome/serum-potassiummmol/L · concentration — Potassium concentration in serum or plasma by ion-selective electrode on a clinical chemistry or metabolic panel analyser, in mmol/L (numerically…1 compound

Serum thyroid peroxidase antibody (TPOAb) titreEndpointCAT:outcome/serum-tpo-antibody-titreU/mL · concentration — Thyroid peroxidase autoantibody (anti-TPO, TPOAb, TPO-Ab) concentration or titre in serum by clinical immunoassay, in U/mL or IU/mL as reported. The…1 compound

Serum thyroid-stimulating hormone (TSH)EndpointCAT:outcome/serum-thyroid-stimulating-hormonemIU/L · concentration — Thyrotropin (thyroid-stimulating hormone, TSH) concentration in serum or plasma by clinical immunoassay, in mIU/L. The assay platform is recorded…1 compound

Six-minute walk test distanceEndpointCAT:outcome/six-minute-walk-distancemetres · size and mass — Total distance covered in six minutes of self-paced walking along a flat measured corridor under the ATS six-minute walk protocol, with standardised…1 compound

Sperm concentrationEndpointCAT:outcome/sperm-concentration10^6/mL · concentration — Sperm concentration in ejaculate by standard semen analysis (manual haemocytometer counting or computer-assisted sperm analysis), expressed as…1 compound

Stool frequencyEndpointCAT:outcome/stool-frequencystools/day · rate and power — Number of stools passed per 24 hours, recorded in a participant- or caregiver-completed bowel diary over a stated observation period. The diary…1 compound

Stratum corneum hydration (corneometry)EndpointCAT:outcome/stratum-corneum-hydrationarbitrary units (corneometer) · score — Electrical capacitance of the stratum corneum measured with a corneometer probe at a defined skin site after a standardised acclimatisation period,…1 compound

Systolic blood pressure (office/clinic)EndpointCAT:outcome/office-systolic-blood-pressuremmHg · pressure — Systolic blood pressure taken at a clinic visit with the participant seated after a stated rest period, by auscultatory or validated automated cuff…1 compound

Time to first postoperative analgesic requestEndpointCAT:outcome/time-to-first-postoperative-analgesic-requesthours · duration — Elapsed time from the end of a surgical or anaesthetic procedure to the patient's first request for, or administration of, rescue analgesia.1 compound

Time to first urinary tract infection recurrenceEndpointCAT:outcome/time-to-first-uti-recurrencedays · duration — Days from the start of treatment to the first culture-documented urinary tract infection recurrence, in days. Follow-up length and censoring handling…1 compound

Urinary lactulose/mannitol ratioEndpointCAT:outcome/urinary-lactulose-mannitol-ratioratio · proportion — Ratio of lactulose to mannitol recovered in urine following an oral dual-sugar challenge, quantified by HPLC or LC-MS. Collection window recorded…1 compound

WOMAC pain subscaleEndpointCAT:outcome/womac-pain-subscalepoints · score — Western Ontario and McMaster Universities Osteoarthritis Index pain subscale, 5 items, administered in Likert (0-20) or visual-analogue format. The…1 compound

WOMAC physical function subscaleEndpointCAT:outcome/womac-function-subscalepoints · score — Western Ontario and McMaster Universities Osteoarthritis Index physical function subscale, 17 items, administered in Likert (0-68) or visual-analogue…1 compound

WOMAC stiffness subscaleEndpointCAT:outcome/womac-stiffness-subscalepoints · score — Western Ontario and McMaster Universities Osteoarthritis Index stiffness subscale, 2 items, administered in Likert (0-8) or visual-analogue format.1 compound

All endpoints