Endpoint
Body weight gain over a feeding or growth period
CAT:outcome/body-weight-gainreported in g3 findings from 2 compounds
What moved it
How to read these marks3 findings · 2 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-leucine | down 1 · no effect 1 | 2 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
| maltitol | down | 1 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
Reported to move it
2 findings
maltitol — decreases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Intake of 5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia.”
Quoted verbatim from Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets.. - Study
- animal · not in humans
- Duration
- 8 weeks
- Dose
- 5.0% maltitol in the diet
- Population
- C57BL/6 male mice fed a high-fat diet
Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets.2015PMID:26061453Permalink
L-leucine — decreases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Feeding of HFMP and HFL resulted in a lower body weight gain compared to HF due to a reduced fat mass accumulation.”
Quoted verbatim from Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.. - Study
- animal · not in humans
- Duration
- 5 months
- Dose
- 50 g/kg diet L-leucine
- Population
- Male C57BL/6JRj mice on a 40 energy% high-fat diet; HFL arm is the high-fat diet with 50 g/kg L-leucine added, compared with unsupplemented high-fat diet (both 140 g/kg casein); 20-week feeding
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.2022PMID:35418570Permalink
Measured, no effect detected
1 finding
L-leucine — no detected effect on
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.FindingNull result“Doubling dietary leucine reversed many of the metabolite abnormalities and caused a marked improvement in glucose tolerance and insulin signaling without altering food intake or weight gain.”
Quoted verbatim from Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.. - Study
- animal · not in humans
- Dose
- dietary leucine doubled by addition to drinking water
- Population
- Mice on a high-fat diet for 8 weeks, with dietary leucine doubled by addition to the drinking water, compared with high-fat diet mice on unsupplemented drinking water
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.2011PMID:21731668Permalink
How it is measured
Increase in whole-body mass of an animal between the start and end of a stated feeding or growth period, final mass minus initial mass on a calibrated scale, in grams. Species and period length are recorded with each finding.
Sources cited
3 papers
- Subject
- body weight gain over a feeding or growth period
- Findings
- 3
- Papers
- 3
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.record2022PMID:354185701 finding
Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets.record2015PMID:260614531 finding
Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism.record2011PMID:217316681 finding