Mean arterial pressure

Method

Mean arterial pressure, either computed from a seated cuff systolic and diastolic reading or obtained directly by oscillometric or intra-arterial monitoring. The acquisition and the timepoint (post-infusion, 1 h, 6 h) are recorded on the edge.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

SIGN INVERSION HAZARD, and it lives inside this node rather than beside it. This node carries the blood-pressure-lowering context, where a fall is the benefit. Edges from vasopressor and vasodilatory-shock trials, where RAISING mean arterial pressure to a haemodynamic target is the therapeutic goal (+1.3 mmHg and upward is the reported benefit in that literature), MUST NOT attach here — the identical number, in mmHg, from the same class of device, improves by RISING there. PMID 39800868 in pre-eclampsia sits on that boundary. This endpoint should be split by clinical context before it carries many edges. Also not interchangeable with systolic or diastolic blood pressure: it is a weighted combination and can be flat while either component moves.

Findings

4 findings from 1 compound, strongest first.

• melatonin — no detected effect on

  CSuggestiveGrade C, Suggestive. Weak human evidence, or strong evidence in a mismatched population.FindingNull resultreplicated ×1

  “Mean Daytime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 102.2 +/-1.7 (n=36) vs Placebo 102.1 +/-1.8 (n=36); difference 0.1; p=0.97, no significant difference”

  Study

  crossover

  Participants

  72

  Population

  Hypertension; 18 Years+

  Effect 0.1 mean difference

  Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360

• melatonin — no detected effect on

  CSuggestiveGrade C, Suggestive. Weak human evidence, or strong evidence in a mismatched population.FindingNull resultreplicated ×1

  “Mean Nighttime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 92.9 +/-1.9 (n=36) vs Placebo 92.6 +/-2.0 (n=36); difference 0.3; p=0.79, no significant difference”

  Study

  crossover

  Participants

  72

  Population

  Hypertension; 18 Years+

  Effect 0.3 mean difference

  Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360

• melatonin — no detected effect on

  CSuggestiveGrade C, Suggestive. Weak human evidence, or strong evidence in a mismatched population.FindingNull resultreplicated ×1

  “Mean Nighttime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 93.9 +/-1.8 (n=36) vs Placebo 94.4 +/-1.8 (n=36); difference -0.5; p=0.91, no significant difference”

  Study

  crossover

  Participants

  72

  Population

  Hypertension; 18 Years+

  Effect -0.5 mean difference

  Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373

• melatonin — no detected effect on

  CSuggestiveGrade C, Suggestive. Weak human evidence, or strong evidence in a mismatched population.FindingNull resultreplicated ×1

  “Mean Daytime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 101.26 +/-1.9 (n=36) vs Placebo 103.5 +/-1.9 (n=36); difference -2.24; p=0.12, no significant difference”

  Study

  crossover

  Participants

  72

  Population

  Hypertension; 18 Years+

  Effect -2.24 mean difference

  Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373