Endpoint
Mean arterial pressure
The blood pressure in the arteries. It is commonly measured with a sphygmomanometer on the upper arm which represents the arterial pressure in the brachial artery.
CAT:outcome/mean-arterial-pressurereported in mmHg9 findings from 5 compounds
What moved it
How to read these marks9 findings · 5 compounds · 6 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| melatonin | no effect | 5 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
| Vitis vinifera | down | 1 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
| caffeine | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| nitrate | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| rebaudioside A | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
Vitis vinifera — decreases
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“Our results indicated that GSE decreased resting DBP (75 ± 2 vs. 71 ± 3) and MAP (91 ± 2 vs. 88 ± 3) compared to the placebo (DBP:71 ± 3 vs. 74 ± 3; MAP: 89 ± 2 vs. 90 ± 2).”
Quoted verbatim from Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.. - Study
- crossover
- Population
- Males with elevated and stage 1 hypertension in a double-blind placebo-controlled cross-over trial of short-term dietary grape seed extract supplementation with a 1-week wash-out; resting MAP
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.2025PMID:40341867Permalink
nitrate — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Unlike PLA, DNS lowered both QL and MAP by ∼8% (P < 0.05), but did not alter LVC (P = 0.31).”
Quoted verbatim from On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise.. - Study
- crossover
- Duration
- 3 days
- Dose
- Beetroot juice, 4.1 mmol NO3-/day, 3-day supplementation vs placebo
- Population
- Recreationally active men, n=11; measured during constant-load and incremental cycling exercise
On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise.2021PMID:34672767Permalink
caffeine — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“During recovery, HR, mean arterial pressure (MAP), and diastolic blood pressure (DBP) remained elevated with caffeine (p < 0.05).”
Quoted verbatim from Caffeine delays autonomic recovery following acute exercise.. - Study
- crossover
- Participants
- 18
- Dose
- 400 mg caffeine pill
- Population
- 18 healthy adults (26±1 years), 5-30 min after a maximal treadmill test to exhaustion
Caffeine delays autonomic recovery following acute exercise.2015PMID:25297344Permalink
Measured, no effect detected
6 findings
melatonin — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Daytime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 102.2 +/-1.7 (n=36) vs Placebo 102.1 +/-1.8 (n=36); difference 0.1; p=0.97, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect 0.1 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
melatonin — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Nighttime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114360: Melatonin 92.9 +/-1.9 (n=36) vs Placebo 92.6 +/-2.0 (n=36); difference 0.3; p=0.79, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect 0.3 mean difference
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study2015NCT01114360Permalink
melatonin — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Daytime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 101.26 +/-1.9 (n=36) vs Placebo 103.5 +/-1.9 (n=36); difference -2.24; p=0.12, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -2.24 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
melatonin — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×2“Mean Nighttime Mean Arterial Pressure (MAP) (SECONDARY, mmHg) -- NCT01114373: Melatonin 93.9 +/-1.8 (n=36) vs Placebo 94.4 +/-1.8 (n=36); difference -0.5; p=0.91, no significant difference”
Quoted verbatim from Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study. - Study
- crossover
- Participants
- 72
- Population
- Hypertension; 18 Years+
Effect -0.5 mean difference
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study2015NCT01114373Permalink
rebaudioside A — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Compared with placebo, rebaudioside A did not significantly alter resting, seated SBP, DBP, mean arterial pressure (MAP), heart rate (HR) or 24-h ambulatory blood pressures responses.”
Quoted verbatim from The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 1000 mg/day rebaudioside A for 4 weeks
- Population
- healthy adults with normal and low-normal blood pressure
The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure.2008PMID:18555574Permalink
melatonin — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“The absolute and percent change in MAP during IHG was not different between conditions (all P > 0.05).”
Quoted verbatim from Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.. - Study
- RCT
- Participants
- 22
- Duration
- 10 days
- Dose
- 10 mg/day melatonin supplementation during a 10-day high-sodium diet
- Population
- normotensive young adults on a 10-day high-sodium diet; MAP reactivity during isometric handgrip (IHG) exercise at 40% maximal voluntary contraction
Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.2023PMID:37642281Permalink
How it is measured
Mean arterial pressure, either computed from a seated cuff systolic and diastolic reading or obtained directly by oscillometric or intra-arterial monitoring. The acquisition and the timepoint (post-infusion, 1 h, 6 h) are recorded with each finding.
Measured, not recorded
- Subject
- mean arterial pressure
- Measurements
- 17 measurements
- Recorded as a finding
- No
Show what was measured
mean arterial pressure
increases, increased to 83 ± 2 mm Hg
The norepinephrine dose was decreased, to zero in four of five sheep, whereas mean arterial pressure increased (to 83 ± 2 mm Hg).
PMID:33239507 · both readings recorded this
mean arterial pressure
increases
Regarding hemodynamics, MB increased the mean arterial pressure, heart rate and peripheral vascular resistance.
PMID:36237547 · both readings recorded this
mean arterial pressure
no effect, n = 100
Compared with placebo, rebaudioside A did not significantly alter resting, seated SBP, DBP, mean arterial pressure (MAP), heart rate (HR) or 24-h ambulatory blood pressures responses
PMID:18555574 · one of two readings recorded this
mean arterial pressure
increases, n = 30
The MAP was significantly higher in the methylene blue-treated group starting 25 min after the amlodipine infusion (95% CI, 2–30)
PMID:25441767 · one of two readings recorded this
mean arterial pressure
decreases
Mean arterial pressure (mmHg) | 117 ± 2 | 126 ± 3 a | 109 ± 1 b
PMID:25517031 · one of two readings recorded this
mean arterial pressure
decreases, significant reduction from week 3
Not recorded as a finding: The sentence gives the week of first significant reduction but no placebo comparator is stated in it, so it is not a between-arm contrast.
HS produced a significant reduction in mean arterial pressure (MAP) from week 2 whereas lisinopril did from week 3.
PMID:26600645 · one of two readings recorded this
mean arterial pressure
decreases
HS produced a significant reduction in mean arterial pressure (MAP) from week 2 whereas lisinopril did from week 3
PMID:26600645 · one of two readings recorded this
mean arterial pressure
decreases
HS produced a significant reduction in mean arterial pressure (MAP) from week 2 whereas lisinopril did from week 3
PMID:26600645 · one of two readings recorded this
mean arterial pressure
no effect
Pooled analysis revealed that mean arterial pressure, systemic vascular resistance, heart rate, and hospital stay were not statistically significant in methylene blue administration compared to control
PMID:33653154 · one of two readings recorded this
mean arterial pressure
no effect, n = 19
There were no significant differences in SBP, DBP and mean arterial pressure (MAP) from the control phase to the intervention phase
PMID:34360460 · one of two readings recorded this
mean arterial pressure
decreases
mean arterial pressure and heart rate were decreased before general anesthesia induction, immediately after tracheal intubation, and at the end of the operation
PMID:37128727 · one of two readings recorded this
mean arterial pressure
no effect, MD -2.05 mmHg, 95% CI -9.89 to 5.79, p = 0.61
The overall MD for mean arterial pressure did not favor either the melatonin or placebo groups (MD = −2.05 mmHg, 95% CI [−9.89, 5.79], p = 0.61, very low certainty of evidence) C).
PMID:37374268 · one of two readings recorded this
mean arterial pressure
increases, p = 0.001
MB was associated with increased mean arterial pressure (MD, 8.4 mmHg [95% CI 5.01-11.75] p < 0.001)
PMID:37880041 · one of two readings recorded this
mean arterial pressure
no effect, p = 0.77
MAP, mm Hg | 84 ± 7 | 84 ± 7 | 0.77
PMID:38110301 · one of two readings recorded this
Mean arterial pressure
decreases, n = 30
Remarkably, when adjusted for the baseline values of each group, SBP and MAP, but not DBP, were significantly lower in the EGCG group compared to the placebo group at week 8 (P < 0.05 all) (Table 1).
PMID:39285220 · one of two readings recorded this
mean arterial pressure
increases
Hydroxocobalamin was associated with a significant improvement in mean arterial pressure at 1 hour (MD: 5.30 mmHg, 95% CI: 2.98 to 7.62)
PMID:39438181 · one of two readings recorded this
Mean arterial pressure
decreases, p = 0.001, n = 12
Mean arterial pressure (mmHg) | 99.5 (85.3, 116.3) | 92.6 (78.3, 104) | −6.94 (−8.7, −5.2) | < 0.001 | 96.7 (80.3, 105.3) | 97.8 (84,7, 119.7) | 1.06 (−1.16, 3.27) | 0.35 | −8.0 (−10.9, −5.1) | < 0.001
PMID:42244145 · one of two readings recorded this
Sources cited
7 papers
- Subject
- mean arterial pressure
- Findings
- 9
- Papers
- 7
Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension.record2025PMID:403418671 finding
Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet.record2023PMID:376422811 finding
On the implication of dietary nitrate supplementation for the hemodynamic and fatigue response to cycling exercise.record2021PMID:346727671 finding
Caffeine delays autonomic recovery following acute exercise.record2015PMID:252973441 finding
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Studyrecord2015NCT011143732 findings
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Studyrecord2015NCT011143602 findings
The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure.record2008PMID:185555741 finding