Endpoint
Incidence of postoperative delirium
CAT:outcome/postoperative-delirium-incidencereported in event rate2 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| melatonin | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| methylene blue | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
2 findings
methylene blue — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“A total of 55 patients (17.5%) experienced POD, with a lower POD incidence in the methylene blue group than in the control group (11.5% vs. 23.6%, p = 0.005).”
Quoted verbatim from Intraoperative methylene blue infusion reduces postoperative delirium in patients undergoing pancreatic surgery: A randomized controlled clinical trial.. - Study
- RCT
- Dose
- methylene blue 2 mg/kg IV within 60 min after anesthetic induction, followed by 1 mg/kg IV within 30 min before end of surgery
- Population
- adult patients undergoing pancreatic surgery
Intraoperative methylene blue infusion reduces postoperative delirium in patients undergoing pancreatic surgery: A randomized controlled clinical trial.2025PMID:41176956Permalink
melatonin — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Melatonin administered less than 5 elimination half-lives before the surgery significantly reduced the POD incidence (OR = 0.31, 95% CI 0.19-0.49, P < .00001).”
Quoted verbatim from Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- Adult surgical patients; subgroup pooled analysis (6 RCTs, 2 cohort studies, 1 case-control study) restricted to melatonin administered less than 5 elimination half-lives before surgery
Effect 0.31 odds ratio, 95% CI 0.19 to 0.49
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.2020PMID:32145098Permalink
How it is measured
New-onset delirium during the postoperative period in adult surgical patients, diagnosed by a validated assessment (Confusion Assessment Method, DSM criteria or equivalent). Assessment window in days recorded with each finding.
Sources cited
2 papers
- Subject
- incidence of postoperative delirium
- Findings
- 2
- Papers
- 2
Intraoperative methylene blue infusion reduces postoperative delirium in patients undergoing pancreatic surgery: A randomized controlled clinical trial.record2025PMID:411769561 finding
Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis.record2020PMID:321450981 finding