What moved it

5 findings · 3 compounds · 1 null · by evidence strength

Compound	Direction	Findings	Strongest evidence
berberine	down	1	Evidence strength: limited.
Ca(2+)	down	2	Evidence strength: very limited.
folic acid	no effect 1 · down 1	2	Evidence strength: very limited.

Direction

Strength, at least

berberineMoved: lowersEffect, as reportedHR0.62[0.49 to 0.79]Evidence: LimitedPaper: PMID:407958462025
Who
Patients with resected colorectal adenoma from the CBAR trial, extended 6-year post-treatment follow-up (CBAR-FE study); sensitivity-analysis estimate
Dose studied
not reported
Sensitivity analyses also demonstrated the same trend: patients in the berberine group had lower risk of colorectal adenoma recurrence (adjusted HR, 0.62; 95% CI: 0.49–0.79; p < 0.001) (Table S2).”
Quoted verbatim from Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial.cohortPermalink
folic acidMoved: no effectEffect, as reportedRR0.82[0.59 to 1.13]Evidence: Very limitedPaper: PMID:198644092009
Who
Participants of the Health Professionals Follow-Up Study and Nurses' Health Study with prior adenoma, randomised to folic acid or placebo; whole-population primary endpoint
Dose studied
1 mg/d
Incidence of at least one recurrent adenoma was not significantly associated with folic acid supplementation [relative risk (RR): 0.82; 95% CI: 0.59,1.13; P = 0.22].”
Quoted verbatim from A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma.RCTPermalink
folic acidMoved: lowersEffect, as reportednot reportedEvidence: Very limitedPaper: PMID:186802282008
Who
Patients with colorectal adenomas at a VA Medical Center, polyps removed at baseline colonoscopy
Dose studied
5 mg folic acid daily vs matched placebo for 3 years
High dose folic acid supplementation is associated with a significant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia.”
Quoted verbatim from Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial.RCTPermalink
Ca(2+)Moved: lowersEffect, as reportedRR0.8[0.69 to 0.94]Evidence: Very limitedPaper: PMID:206854912010
Who
Individuals with a history of colorectal adenomas, three pooled trials versus placebo
Dose studied
calcium 1200 to 2000 mg/d
Meta-analysis of 3 trials in individuals with a history of adenomas showed a statistically significant reduction in the RR for adenoma recurrence (RR = 0.80 [95% CI, 0.69-0.94], P = 0.006) for those receiving calcium 1200 to 2000 mg/d, but no effect was seen in advanced adenoma (RR = 0.77 [95% CI, 0.501.17], P = NS).”
Quoted verbatim from Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis.meta-analysisPermalink
Ca(2+)Moved: lowersEffect, as reportedRR0.8[0.68 to 0.93]Evidence: Very limitedPaper: PMID:156674972005
Who
Subjects with previously removed adenomas in 3 randomised trials of calcium versus placebo supplementation
Dose studied
not reported
We found that the recurrence of adenomas was significantly lower in subjects randomized to calcium supplementation (RR: 0.80, CI: 0.68, 0.93; p-value = 0.004).”
Quoted verbatim from Role of supplemental calcium in the recurrence of colorectal adenomas: a metaanalysis of randomized controlled trials.meta-analysisPermalink

How it is measured

Recurrence of colorectal adenoma detected at surveillance colonoscopy following prior polypectomy, ascertained at the protocol's stated follow-up interval (commonly 1 or 2 years).

Papers about this node

Papers: 12
Read with it as an endpoint: 12

Read with it as an endpoint12 papers

Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial.
Cell reports. Medicine2025PMID:40795846Via: named in the paper, as read
Calcium and dairy products in the chemoprevention of colorectal adenomas: a systematic review and meta-analysis.
Critical reviews in food science and nutrition2022PMID:33951958Via: named in the paper, as read
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study.
The lancet. Gastroenterology & hepatology2020PMID:31926918Via: named in the paper, as read
Body mass index, calcium supplementation and risk of colorectal adenomas.
International journal of cancer2019PMID:30117164Via: named in the paper, as read
Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial.
Lancet (London, England)2018PMID:30466866Via: named in the paper, as read
Effects of calcium on the incidence of recurrent colorectal adenomas: A systematic review with meta-analysis and trial sequential analysis of randomized controlled trials.
Medicine2017PMID:28796047Via: named in the paper, as read
Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials.
World journal of gastroenterology2016PMID:27182169Via: named in the paper, as read
Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes.
Journal of the National Cancer Institute2016PMID:27530657Via: named in the paper, as read
Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis.
Clinical therapeutics2010PMID:20685491Via: named in the paper, as read
A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma.
The American journal of clinical nutrition2009PMID:19864409Via: named in the paper, as read
Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial.
World journal of gastroenterology2008PMID:18680228Via: named in the paper, as read
Role of supplemental calcium in the recurrence of colorectal adenomas: a metaanalysis of randomized controlled trials.
The American journal of gastroenterology2005PMID:15667497Via: named in the paper, as read

Sources cited

5 papers

Subject: colorectal adenoma recurrence after polypectomy
Findings: 5
Papers: 5