Core body temperature

Method

Core body temperature in degrees Celsius by an instrument that reads a CORE site -- rectal probe, oesophageal probe, or ingestible telemetric pill. Site recorded on the edge, because the three do not agree during exercise: oesophageal tracks arterial change fastest and rectal lags it by several minutes at the same true core temperature.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

SKIN and TYMPANIC temperature are different measurements and must not map here -- skin temperature can fall while core rises, so the direction can invert. Distinct also from FEVER or febrile-episode endpoints, which are event counts rather than a temperature. Minted from three papers across two compounds: caffeine raising core temperature during exercise (PMIDs 41774477, 35616851) and melatonin lowering it (PMID 23771573), which is also why the node is not named for either direction.