Endpoint
Cortical cataract incidence
CAT:outcome/cortical-cataract-incidencereported in relative risk1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-ascorbic acid | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
L-ascorbic acid — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“For subtypes, there were no significant effects of vitamin C on incidence of nuclear (HR, 1.01; CI, 0.89-1.14), cortical (HR, 1.10; CI, 0.92-1.31), or PSC cataract (HR, 0.94; CI, 0.76-1.17) (Table 2).”
Quoted verbatim from Age-related cataract in a randomized trial of vitamins E and C in men.. - Study
- RCT
- Dose
- 500 mg synthetic ascorbic acid daily versus placebo
- Population
- 11,545 apparently healthy US male physicians aged 50 years or older without cataract at baseline, in a 2x2x2x2 factorial trial where vitamin E, multivitamin and beta-carotene were randomised independently of vitamin C
Effect 1.1 hazard ratio, 95% CI 0.92 to 1.31
Age-related cataract in a randomized trial of vitamins E and C in men.2010PMID:21060040Industry fundedPermalink
How it is measured
Incident cortical age-related lens opacity by standardised slit-lamp lens grading or documented clinical diagnosis.
Measured, not recorded
- Subject
- cortical cataract incidence
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
cortical cataract incidence
lutein RR 0.82 (95% CI 0.56-1.08); zeaxanthin RR 0.76 (95% CI 0.48-1.04)
The comparisons of the highest with the lowest blood concentrations of lutein (RR: 0.82; 95% CI: 0.56, 1.08) and zeaxanthin (RR: 0.76; 95% CI: 0.48, 1.04) were associated with 20% and 26% statistically nonsignificant reduction in cortical cataract risks, respectively.
PMID:24451312 · one of two readings recorded this
Sources cited
1 paper
- Subject
- cortical cataract incidence
- Findings
- 1
- Papers
- 1