Endpoint
Subjective fatigue
CAT:outcome/subjective-fatiguereported in instrument-specific score4 findings from 4 compounds
What moved it
How to read these marks4 findings · 4 compounds · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| melatonin | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| paroxetine | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| coenzyme Q10 | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| resveratrol | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
paroxetine — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Fatigue scores improved significantly in both groups, but the reduction was larger in the paroxetine group [7.75 (6.9–8.52) → 4.5 (3.27–7.27)] compared to the control group [7.55 (7–8.4) → 5.85 (4.57–8.25); p = 0.006 between groups].”
Quoted verbatim from Efficacy of Paroxetine as an Adjuvant Therapy in Rheumatoid Arthritis Patients: A Randomized Controlled Study.. - Study
- RCT
- Duration
- 3 months
- Dose
- paroxetine 20 mg once daily
- Population
- Adults with active mild or moderate rheumatoid arthritis, all on methotrexate-based csDMARDs and prednisolone 10 mg/day in both arms; paroxetine plus csDMARD versus placebo plus csDMARD; three-month result, intention-to-treat with baseline observation carried forward
Efficacy of Paroxetine as an Adjuvant Therapy in Rheumatoid Arthritis Patients: A Randomized Controlled Study.2025PMID:41488752Permalink
melatonin — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After the intervention, not only the mean fatigue score was significantly lower in melatonin group (2.93 ± 1.04 vs 1.99 ± 1.02, P < .001, P ≤ .05), but also a greater reduction in fatigue score in intervention group was evident over time (P ≤ .001).”
Quoted verbatim from A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments.. - Study
- RCT
- Dose
- 18 mg/day from 1 week before adjuvant treatments until 2 years after their completion
- Population
- Breast cancer patients receiving adjuvant treatments; melatonin versus placebo, Brief Fatigue Inventory
A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments.2023PMID:37139718Permalink
resveratrol — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Two parameters of Profile of Mood States (POMS) including vigor and fatigue, decreased significantly by resveratrol.”
Quoted verbatim from Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients.. - Study
- meta-analysis
- Population
- Adults across 4 pooled randomized controlled trials (226 individuals) evaluating resveratrol's effect on cognition, memory and mood
Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients.2018PMID:28844841Permalink
Measured, no effect detected
1 finding
coenzyme Q10 — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“No significant benefit was observed for fatigue (SMD: -0.33; 95% CI: -1.38 to 0.72; P =0.54; I2 =89%), based on only 2 trials.”
Quoted verbatim from Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. - Study
- meta-analysis
- Population
- patients with depression, primary or comorbid with medical illness; pooled across 2 trials
Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.2025PMID:41294251Permalink
How it is measured
Score on a named validated self-report instrument measuring FATIGUE specifically. Instrument recorded with each finding.
Measured, not recorded
- Subject
- subjective fatigue
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
subjective fatigue
positive trend for astaxanthin in subjective fatigue relief
The results of the two existing studies showed a positive trend for astaxanthin in subjective fatigue relief.
PMID:38243785 · one of two readings recorded this
Sources cited
4 papers
- Subject
- subjective fatigue
- Findings
- 4
- Papers
- 4
Effects of Coenzyme Q10 Supplementation on Depressive Symptoms and Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.record2025PMID:412942511 finding
Efficacy of Paroxetine as an Adjuvant Therapy in Rheumatoid Arthritis Patients: A Randomized Controlled Study.record2025PMID:414887521 finding
A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments.record2023PMID:371397181 finding
Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients.record2018PMID:288448411 finding