Endpoint
Blood urea nitrogen
The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
CAT:outcome/blood-urea-nitrogenreported in mg/dL1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| curcumin | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
curcumin — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“After the treatment of MRL. lpr female mice (8–10 weeks old) with curcumin at 1 g/kg bodyweight, daily for 2 months, we found that 24-h proteinuria and serum BUN levels were significantly reduced compared to the placebo group, p < 0.05.”
Quoted verbatim from Curcumin Attenuates Both Acute and Chronic Immune Nephritis.. - Study
- animal · not in humans
- Duration
- 2 months
- Dose
- 1 g/kg body weight daily by oral gavage
- Population
- female MRL.lpr lupus mice aged 8-10 weeks, curcumin or sesame-oil placebo daily for 2 months
Curcumin Attenuates Both Acute and Chronic Immune Nephritis.2020PMID:32143311Permalink
How it is measured
Serum urea nitrogen concentration by clinical assay, reported on the nitrogen scale.
Measured, not recorded
- Subject
- blood urea nitrogen
- Measurements
- 15 measurements
- Recorded as a finding
- No
Show what was measured
Blood urea nitrogen
increases, p = 0.01
blood urea nitrogen increased (p = .01) with HMB, arginine, and glutamine supplementation
PMID:15080599 · one of two readings recorded this
Blood urea nitrogen
no effect
BUN (mM) | 7±1 | 72±17a | 18±2a,c | 62±4a,e | 16±1a,c,f
PMID:21494626 · one of two readings recorded this
Blood urea nitrogen
no effect
BUN (mM) | 7±1 | 72±17a | 18±2a,c | 62±4a,e | 16±1a,c,f
PMID:21494626 · one of two readings recorded this
blood urea nitrogen
decreases
Serum creatinine and blood urea nitrogen levels followed the similar trend, significantly increased by the exercise stress and restored to the normal baseline levels by CS disaccharides under the stressed condition
PMID:28754911 · one of two readings recorded this
blood urea nitrogen
increases
Serum creatinine and blood urea nitrogen levels followed the similar trend, significantly increased by the exercise stress and restored to the normal baseline levels by CS disaccharides under the stressed condition
PMID:28754911 · one of two readings recorded this
Blood urea nitrogen
decreases
blood urea nitrogen (MD -1.00; 95% CI -1.36 to -0.63)
PMID:31201013 · one of two readings recorded this
blood urea nitrogen
no effect
However, with the exception for proteinuria, their impact on clinical parameters, such as blood urea nitrogen, creatinine, glomerular filtration rate (GFR), and serum albumin, was weak and not significant.
PMID:34331699 · one of two readings recorded this
Blood urea nitrogen
decreases, p = 0.00001, n = 312
RSV could significantly decrease BUN level compared with the control group [n = 312, SMD = −2.51, 95% CI (−3.26, −1.76), p < 0.00001
PMID:35355720 · one of two readings recorded this
Blood urea nitrogen
decreases
Better therapeutic effects were observed when studies used type 1 DN models (p = 0.000), intervention duration of ≥12 weeks (p = 0.000), and rats (p = 0.000)
PMID:35355720 · one of two readings recorded this
Blood urea nitrogen
no effect, p = 0.508, n = 51
BUN | 70.58 (63.80) | 55.13 (52.60) | 0.187 | −15.46 (11.38) | 66.26 (39.18) | 61.11 (41.80) | 0.569 | −5.1 (8.93) | 0.508
PMID:36597167 · one of two readings recorded this
blood urea nitrogen
increases
Creatine supplementation increased serum Crn (only in males), reduced Crn clearance, and enhanced blood urea nitrogen, suggesting an impaired kidney function
PMID:36986197 · one of two readings recorded this
blood urea nitrogen
no effect, p = 0.807
BUN (mmol/L) | 28.83 ± 6.58 | 28.38 ± 7.65 | 0.246 |.807
PMID:37009975 · one of two readings recorded this
Blood urea nitrogen
decreases, n = 778
The pooled results showed that the Cordyceps group was superior to the routine group in reducing BUN (MD = −1.30 mmol/L, 95% CI −2.33 to −0.28, I2 = 97.1%, nine trials, 778 participants)
PMID:38189088 · one of two readings recorded this
Blood urea nitrogen
Blood urea nitrogen, (mg/dL), Mean ± SD | 23.4 ± 10.6 | 18.2 ± 9.4 | NS
PMID:39079962 · one of two readings recorded this
blood urea nitrogen
no effect, p = 0.802, n = 84
Blood urea nitrogen (mmol/L) | 9.8 ± 5.6 | 9.5 ± 5.3 | -0.3 (-2.667 to 2.067) | 0.802
PMID:41449463 · one of two readings recorded this
Sources cited
1 paper
- Subject
- blood urea nitrogen
- Findings
- 1
- Papers
- 1