Endpoint
Hippocampal CA1 long-term potentiation magnitude
CAT:outcome/hippocampal-ca1-ltp-magnitudereported in % of baseline1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| creatine | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
creatine — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Exposure to Cr supplementation during brain development affected LTP in CA1 neurons in adult rats: high-frequency stimulation (HFS) of stratum radiatum induced an intense LTP that increased significantly over time compared to the control group.”
Quoted verbatim from Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- creatine 1 g/100 ml in drinking water to dams, gestation day 11 to day before delivery
- Population
- Adult male Sprague-Dawley rats (postnatal day 60-70) born to dams given creatine in drinking water from gestation day 11 until the day before delivery; hippocampal CA1 slices ex vivo
Maternal Creatine Supplementation Positively Affects Male Rat Hippocampal Synaptic Plasticity in Adult Offspring.2019PMID:31461895Permalink
How it is measured
Magnitude of long-term potentiation at CA1 synapses of Schaffer collateral input in acute hippocampal slices, as field excitatory postsynaptic potential slope after theta-burst or high-frequency conditioning, expressed as percent of the pre-conditioning baseline and read at a stated minutes after conditioning.
Sources cited
1 paper
- Subject
- hippocampal ca1 long-term potentiation magnitude
- Findings
- 1
- Papers
- 1