Endpoint
Gamma-glutamyl transferase
CAT:outcome/gamma-glutamyl-transferasereported in IU/L2 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| Lactobacillus acidophilus | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| sodium benzoate | up | 1 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
Reported to move it
2 findings
Lactobacillus acidophilus — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“After 14 days, UDCA+ L. acid group showed significantly lower AST (p < 0.05), ALT (p < 0.05), ALP, GGT (p < 0.05), and TBIL (p < 0.05) compared to UDCA, while no differences were found at the beginning of the trial (Supplemental Table 3).”
Quoted verbatim from Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.. - Study
- RCT
- Duration
- 14 days
- Dose
- 1 g fixed-dose tablet before each meal, three times a day, for 14 days, added to UDCA
- Population
- Adults with cholestatic liver disease; both arms received ursodeoxycholic acid 250 mg twice daily as background, the control arm UDCA alone; small single-centre trial
Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion.2024PMID:39205654Permalink
sodium benzoate — increases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“In male rats of the 2.4% group, relative liver and kidney weight, serum levels of albumin, total protein and gamma-glutamyl transpeptidase were significantly increased and enlarged hepatocytes with glassy cytoplasm were seen using light microscopy.”
Quoted verbatim from Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.. - Study
- animal · not in humans
- Duration
- 10 days
- Dose
- 2.4% sodium benzoate in diet
- Population
- male F344 rats, 2.4% sodium benzoate in diet for 10 days
Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.1993PMID:8212059Permalink
How it is measured
Serum gamma-glutamyl transferase catalytic activity by clinical enzymatic assay, reported in international units per litre. The assay temperature and reference method are recorded with each finding.
Sources cited
2 papers
- Subject
- gamma-glutamyl transferase
- Findings
- 2
- Papers
- 2