Endpoint

Pre-eclampsia incidence

CAT:outcome/pre-eclampsia-incidencereported in proportion2 findings from 1 compound

What moved it

2 findings · 1 compound · by evidence strength

Compound	Direction	Findings	Strongest evidence
Ca(2+)	down	2	Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.

Reported to move it

2 findings

Ca(2+) — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×1
“Pooled analysis showed that calcium supplementation during pregnancy was associated with a significant reduction of 45% in risk of gestational hypertension [Relative risk (RR) 0.55; 95 % confidence interval (CI) 0.36-0.85] and 59% in the risk of pre-eclampsia [RR 0.41; 95 % CI 0.24-0.69] in developing countries.”
Quoted verbatim from Role of calcium supplementation during pregnancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries..
Study

meta-analysis
Population

Pregnant women in developing countries; pooled analysis of randomised controlled trials
Effect 0.41 risk ratio, 95% CI 0.24 to 0.69
Role of calcium supplementation during pregnancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries.2011PMID:21501435Permalink
Ca(2+) — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1
“There was also a reduction in the risk of pre-eclampsia associated with calcium supplementation (13 trials, 15,730 women: average RR 0.45, 95% CI 0.31 to 0.65; I² = 70%; low-quality evidence).”
Quoted verbatim from Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems..
Study

meta-analysis
Participants

15,730
Dose

at least 1 g/day calcium during pregnancy
Population

Pregnant women; high-dose calcium supplementation (at least 1 g daily) versus placebo, pooled RCTs
Effect 0.45 risk ratio, 95% CI 0.31 to 0.65
Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.2018PMID:30277579Permalink

How it is measured

Proportion of pregnant women with a new diagnosis of pre-eclampsia, defined as new-onset hypertension after 20 weeks of gestation together with proteinuria or other maternal organ dysfunction, by a stated clinical diagnostic criteria set. The criteria set is recorded with each finding, and so is whether eclampsia was counted together with pre-eclampsia as a single event.

Sources cited

2 papers

Subject: pre-eclampsia incidence
Findings: 2
Papers: 2

Compound

Direction

Findings

Strongest evidence

Ca(2+)

down

How it is measured