Endpoint
Mean arterial pressure in vasodilatory shock
CAT:outcome/mean-arterial-pressure-in-vasodilatory-shockreported in mmHg2 findings from 1 compound
What moved it
How to read these marks2 findings · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| methylene blue | no effect 1 · up 1 | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
methylene blue — increases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“The MAP was significantly higher in the methylene blue-treated group starting 25 min after the amlodipine infusion (95% CI, 2–30) that was analyzed up until 60 minutes.”
Quoted verbatim from Efficacy of methylene blue in an experimental model of calcium channel blocker-induced shock.. - Study
- animal · not in humans
- Dose
- 2 mg/kg over 5 minutes at minutes 5, 30 and 60
- Population
- anaesthetised, ventilated Sprague-Dawley rats given an LD50 amlodipine infusion (17 mg/kg/hour) in both arms; MB or normal saline given at minutes 5, 30 and 60; MAP analysed from minute 25 to minute 60
Efficacy of methylene blue in an experimental model of calcium channel blocker-induced shock.2015PMID:25441767Permalink
Measured, no effect detected
1 finding
methylene blue — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Pooled analysis revealed that mean arterial pressure, systemic vascular resistance, heart rate, and hospital stay were not statistically significant in methylene blue administration compared to control.”
Quoted verbatim from Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- adult patients with vasoplegic syndrome, methylene blue as adjunct treatment compared to control treatments
Methylene blue for vasoplegic syndrome in cardiopulmonary bypass surgery: A systematic review and meta-analysis.2021PMID:33653154Permalink
How it is measured
Mean arterial pressure, usually written MAP, by intra-arterial line or oscillometric monitoring, wherever RAISING it to a haemodynamic target is the therapeutic goal. That covers vasodilatory shock — distributive, septic, vasoplegic — and equally the vasopressor and vasoplegia-prophylaxis settings that share its sign: intraoperative vasoplegia, vasopressor-sparing adjuncts, and rescue for refractory hypotension in cardiac surgery or liver transplantation. THE PATIENT NEED NOT MEET A FORMAL SHOCK DEFINITION. The test is the direction of benefit, not the diagnosis. The timepoint (post-infusion, 1 h, 6 h) and the vasopressor background are recorded with each finding: the same rise means different things at the start of a noradrenaline infusion and at the end of a taper.
Sources cited
2 papers
- Subject
- mean arterial pressure in vasodilatory shock
- Findings
- 2
- Papers
- 2