Bronchopulmonary dysplasia of any grade at 36 weeks

Method

Bronchopulmonary dysplasia of ANY severity at 36 weeks postmenstrual age as a binary endpoint, pooled as a risk ratio. As on the severe-disease node, the grading classification is recorded on the edge and is not optional, and so is whether the diagnosis rested on a systematic oxygen-reduction or pulse-oximetry assessment rather than on the treating clinician's ongoing supplemental oxygen -- that choice moves the event rate substantially and the two are not the same endpoint.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

Minted 2026-08-27 alongside CAT:outcome/severe-bpd-at-36-weeks and under the same rule. ADR-0014's floor: PMID 40180500 reports any-grade BPD at adjusted RR 1.09, 95 percent CI 1.01 to 1.18, and PMID 36943265 reports BPD on trial-specific definitions at RR 1.07, 95 percent CI 0.86 to 1.34, and at RR 1.20, 95 percent CI 1.01 to 1.42, in the two trials using systematic pulse-oximetry assessment. Both are DHA in very preterm infants and this node is not yet demonstrated across subjects. WHY THIS ONE MATTERS MORE THAN ITS SIZE SUGGESTS. Two independent extraction passes flagged the same thing: in PMID 40180500 the any-grade result is the ONLY nominally significant between-arm finding in the paper, it runs AGAINST the intervention, and the title and abstract lead with the null primary outcome. Without a node the graph would have held that trial's null and not its signal. A gap in the ontology is not neutral about direction when the endpoints that lack nodes are the ones a positive-results convention buries. HETEROGENEITY IS EXPECTED HERE AND IS A PROPERTY OF THE ESTIMATE, NOT A REASON TO REFUSE THE NODE. PMID 36943265 reports I2 = 72 percent on this endpoint, which is what pooling across differing local definitions produces. Record the definition; do not merge an estimate whose definition is unstated with one whose is. DISTINCT FROM CAT:outcome/severe-bpd-at-36-weeks, a stricter threshold on the same disease that can point the other way in the same paper, from CAT:outcome/bpd-severity-grade-ordinal, an ordinal odds analysis, and from CAT:outcome/death-or-severe-bpd-composite, which adds a competing risk.