Endpoint
Natural killer cell activity
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T cells; and B cells; NK cells are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory cell surface receptors. A subset of t-lymphocytes referred to as natural killer T cells shares some of the properties of this cell type.
CAT:outcome/natural-killer-cell-activityreported in percent cytotoxicity1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| Lactiplantibacillus plantarum | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
Lactiplantibacillus plantarum — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Specifically, NK cell activity, the primary endpoint, showed consistent increases across all effector-to-target (E:T) ratios in the HT-LM1004 group compared with the placebo group in both ITT and PP analyses.”
Quoted verbatim from Microbiome-Modulating Effects of Heat-Treated Lactiplantibacillus plantarum LM1004 and Its Enhancement of NK Cell Activity: Evidence from a Clinical Trial and a Simulated Human Intestinal Microbiome Ecosystem.. - Study
- RCT
- Duration
- 8 weeks
- Dose
- one 500 mg capsule daily after dinner for 8 weeks
- Population
- Healthy adults aged 19-75 with a Perceived Stress Scale score of 16 or more, a white cell count of 3-10 x 10^3 per microlitre and at least two upper respiratory infections in the previous year; intention-to-treat and per-protocol analyses; maltodextrin placebo capsule in the comparator arm
Microbiome-Modulating Effects of Heat-Treated Lactiplantibacillus plantarum LM1004 and Its Enhancement of NK Cell Activity: Evidence from a Clinical Trial and a Simulated Human Intestinal Microbiome Ecosystem.2026PMID:42487409Industry fundedPermalink
How it is measured
Cytotoxic activity of peripheral blood natural killer cells against a standard target cell line, typically K562, by chromium-51 release, flow-cytometric, or lactate dehydrogenase release assay, expressed as percent specific lysis at a stated effector-to-target ratio. The ratio is recorded with each finding and results at different ratios are not comparable.
Sources cited
1 paper
- Subject
- natural killer cell activity
- Findings
- 1
- Papers
- 1