Endpoint
Clinical attachment level (CAL) gain
CAT:outcome/clinical-attachment-level-gainreported in mm2 findings from 1 compound
What moved it
How to read these marks2 findings · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| coenzyme Q10 | up 1 · no effect 1 | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
coenzyme Q10 — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Daily oral supplementation (120 mg/day) with CoQ10 resulted in a greater mean reduction of PD by 0.41 mm (95% CI: 0.02-0.80) and a greater mean CAL gain by 0.52 mm (95% CI: 0.26-0.78) than seen in controls.”
Quoted verbatim from Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.. - Study
- meta-analysis
- Dose
- 120 mg/day
- Population
- adults with periodontitis receiving scaling and root planing; oral CoQ10 supplementation
Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.2025PMID:39920883Permalink
Measured, no effect detected
1 finding
coenzyme Q10 — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“There was no significant effect of local use of CoQ10 on reduction of PD and gain in CAL.”
Quoted verbatim from Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.. - Study
- meta-analysis
- Population
- adults with periodontitis receiving scaling and root planing; locally delivered (topical or intra-pocket) CoQ10
Clinical efficacy of adjunctive use of coenzyme Q10 in non-surgical periodontal treatment: A systematic review.2025PMID:39920883Permalink
How it is measured
Change from baseline in the distance from the cemento-enamel junction to the base of the periodontal sulcus, measured with a manual or pressure-calibrated periodontal probe at defined sites and expressed as gain in millimetres. Probe type, number of sites per tooth, and examiner calibration recorded with each finding.
Measured, not recorded
- Subject
- clinical attachment level (cal) gain
- Measurements
- 1 measurement
- Recorded as a finding
- No
Show what was measured
clinical attachment level (CAL) gain
increases
a greater mean CAL gain by 0.52 mm (95% CI: 0.26-0.78)
PMID:39920883 · one of two readings recorded this
Sources cited
1 paper
- Subject
- clinical attachment level (cal) gain
- Findings
- 2
- Papers
- 1