Endpoint
Carotid-femoral pulse wave velocity
The transit time of an aortic pressure wave between the common carotid artery and the common femoral artery. It is a standard measure of arterial stiffness.
CAT:outcome/carotid-femoral-pulse-wave-velocityreported in m/s1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| curcumin | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Every finding here is a null result.
Measured, no effect detected
1 finding
curcumin — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“There was no group by time interaction for aortic PWV (P=0.8), carotid artery compliance (P=0.2), or other arterial stiffness parameters (all P>0.2).”
Quoted verbatim from Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.. - Study
- RCT
- Duration
- 3 months
- Dose
- 2000 mg/day Longvida® curcumin (~400 mg curcumin), once daily for 12 weeks
- Population
- healthy middle-aged and older adults, 45-74 years
Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.2017PMID:28070018Permalink
How it is measured
Aortic pulse wave velocity derived from the carotid-to-femoral transit time and the surface path length between those two recording sites, by applanation tonometry or a validated oscillometric device. The path-length convention (direct, subtracted, or 0.8 x direct) is recorded with each finding — the three conventions differ by up to 20 percent on the same subject.
Measured, not recorded
- Subject
- carotid-femoral pulse wave velocity
- Measurements
- 2 measurements
- Recorded as a finding
- No
Show what was measured
carotid-femoral pulse wave velocity
no effect, n = 159
We found no differences in pulse wave velocity at 12 months, augmentation index at 12 months, BP, B-type natriuretic peptide, or physical function
PMID:32817311 · one of two readings recorded this
Carotid-femoral pulse wave velocity
no effect, p = 0.552
PWV, cm/sec | 8.9 ± 0.4 | 8.5 ± 0.5 | 9.8 ± 0.4 | 9.1 ± 0.5 | 0.552 | 0.196
PMID:42478598 · one of two readings recorded this
Sources cited
1 paper
- Subject
- carotid-femoral pulse wave velocity
- Findings
- 1
- Papers
- 1