Endpoint
Glutathione peroxidase activity
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water.
CAT:outcome/glutathione-peroxidase-activityreported in U/L6 findings from 5 compounds
What moved it
How to read these marks6 findings · 5 compounds · 3 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| curcumin | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Panax ginseng | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Vitis vinifera | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| resveratrol | up 1 · no effect 1 | 2 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
| creatine | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
curcumin — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“Compared to the placebo group, curcumin supplementation significantly enhanced antioxidant defenses, as evidenced by increased levels of total antioxidant capacity (TAC), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activity at 3, 6, 9, and 12 months.”
Quoted verbatim from Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.. - Study
- RCT
- Duration
- 12 months
- Dose
- Oral ethanolic Curcuma longa rhizome extract standardised to 75-85% total curcuminoids, 250 mg curcuminoids per capsule, three capsules twice daily (1500 mg curcuminoids/day) for 12 months
- Population
- Obese adults with type 2 diabetes mellitus managed on metformin (age >=35 y, BMI >=23 kg/m2, HbA1c <6.5%), Nakhon Nayok, Thailand; 227 randomised, per-protocol analysis and the analysed count is not reported in the paper; secondary endpoint (declared primary outcome: liver steatosis by controlled attenuation parameter on transient elastography); GPx by RANSEL colorimetric assay
Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.2025PMID:41096556Industry fundedPermalink
resveratrol — increases
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.Finding“In addition, compared to placebo, Supplementation with resveratrol significantly increased glutathione peroxidase levels (SMD = 0.38, 95%CI(0.03, 0.74), P = 0.04; Level of evidence:low) and catalase levels (SMD = 0.33, 95%CI(0.03, 0.63), P = 0.03; Level of evidence: low).”
Quoted verbatim from The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.. - Study
- meta-analysis
- Population
- patients with type 2 diabetes mellitus (T2DM)
The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.2024PMID:39872318Permalink
creatine — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Creatine provided additional benefits, increasing GPx, reducing IL-6/TNF-α and improving strength and function when combined with exercise modalities.”
Quoted verbatim from Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 months
- Dose
- 3 g/day
- Population
- older adults (68.2±4.6y); creatine + resistance training (EB or AQ modalities pooled) vs placebo + training
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.2026PMID:41941966Permalink
Measured, no effect detected
3 findings
Panax ginseng — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“However, GSH-Px activities were not changed by P. ginseng administration compared to the placebo (Table 4).”
Quoted verbatim from Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 1 g/day or 2 g/day P. ginseng extract (four 250 mg capsules, twice daily)
- Population
- adults with idiopathic chronic fatigue (ICF); P. ginseng dose arms vs placebo
Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial.2013PMID:23613825Industry fundedPermalink
Vitis vinifera — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“Meta-analysis of five RCTs showed no significant effect of GPCP on GPX levels (WMD = 0.026 U/mgHb; 95% CI: − 0.002, 0.05; P = 0.07).”
Quoted verbatim from The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in five pooled randomized trials of grape products containing polyphenols (grape extract, grape powder, juice, raisin, resveratrol, red wine), healthy and unhealthy participants combined
Effect 0.026 mean difference, 95% CI -0.002 to 0.05
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.2021PMID:33712024Industry fundedPermalink
resveratrol — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Collectively, our findings of available RCTs did no show any benefit of resveratrol supplementation on SOD, CAT and GPx except for TAC.”
Quoted verbatim from Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- adults in randomised controlled trials of resveratrol supplementation
Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.2020PMID:31628212Permalink
How it is measured
Glutathione peroxidase enzymatic activity in erythrocyte lysate, whole blood, plasma or serum, by coupled glutathione-reductase assay following NADPH consumption.
Measured, not recorded
- Subject
- glutathione peroxidase activity
- Measurements
- 13 measurements
- Recorded as a finding
- No
Show what was measured
glutathione peroxidase activity
decreases, p = 0.006
Serum concentrations of substance P (P<0·001) as well as activities of superoxide dismutase (P=0·02), glutathione peroxidase (P=0·006) and catalase (P<0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group.
PMID:22099425 · both readings recorded this
glutathione peroxidase activity
increases
cerebral cortex (F = 153, df = 2), cerebellum (F = 151, df = 2), midbrain (F = 43, df = 2), pons-medulla (F = 152, df = 2), hippocampus (F = 150, df = 2) and hypothalamus (F = 237, df = 2)
PMID:25009784 · one of two readings recorded this
glutathione peroxidase activity
increases
cerebral cortex (F = 153, df = 2), cerebellum (F = 151, df = 2), midbrain (F = 43, df = 2), pons-medulla (F = 152, df = 2), hippocampus (F = 150, df = 2) and hypothalamus (F = 237, df = 2)
PMID:25009784 · one of two readings recorded this
glutathione peroxidase activity
increases
cerebral cortex (F = 153, df = 2), cerebellum (F = 151, df = 2), midbrain (F = 43, df = 2), pons-medulla (F = 152, df = 2), hippocampus (F = 150, df = 2) and hypothalamus (F = 237, df = 2)
PMID:25009784 · one of two readings recorded this
glutathione peroxidase activity
increases
cerebral cortex (F = 153, df = 2), cerebellum (F = 151, df = 2), midbrain (F = 43, df = 2), pons-medulla (F = 152, df = 2), hippocampus (F = 150, df = 2) and hypothalamus (F = 237, df = 2)
PMID:25009784 · one of two readings recorded this
glutathione peroxidase activity
increases
cerebral cortex (F = 153, df = 2), cerebellum (F = 151, df = 2), midbrain (F = 43, df = 2), pons-medulla (F = 152, df = 2), hippocampus (F = 150, df = 2) and hypothalamus (F = 237, df = 2)
PMID:25009784 · one of two readings recorded this
glutathione peroxidase activity
increases
cerebral cortex (F = 153, df = 2), cerebellum (F = 151, df = 2), midbrain (F = 43, df = 2), pons-medulla (F = 152, df = 2), hippocampus (F = 150, df = 2) and hypothalamus (F = 237, df = 2)
PMID:25009784 · one of two readings recorded this
glutathione peroxidase activity
decreases, p = 0.01
glutathione peroxidase (p < 0.01) activity
PMID:26360969 · one of two readings recorded this
Glutathione peroxidase activity
no effect, p = 0.05, n = 87
differences in the mean levels of activities of SOD and GPX, two antioxidant enzymes, among three groups of the study were not significant (P > 0.05 in all cases)
PMID:28074795 · one of two readings recorded this
Glutathione peroxidase activity
increases, p = 0.001
Total antioxidant status, glutathione peroxidase activity, and superoxide dismutase activity were elevated in the curcumin group, whereas malondialdehyde levels were greater in the placebo group (p < 0.001 for all).
PMID:39125295 · one of two readings recorded this
glutathione peroxidase activity
increases
CoQ-10 ameliorated oxidative stress by decreasing malondialdehyde levels and increasing catalase, glutathione peroxidase activities, and glutathione levels in the liver tissues
PMID:39449772 · one of two readings recorded this
glutathione peroxidase activity
decreases
In the diabetic group, the activity of glutathione peroxidase, catalase enzymes, and glutathione levels was decreased with an increase in malondialdehyde level
PMID:39449772 · one of two readings recorded this
glutathione peroxidase activity
increases
Curcumin significantly increased glutathione peroxidase activity compared with placebo (Table 2)
PMID:40573083 · one of two readings recorded this
Sources cited
6 papers
- Subject
- glutathione peroxidase activity
- Findings
- 6
- Papers
- 6
Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial.record2026PMID:419419661 finding
Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.record2025PMID:410965561 finding
The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.record2024PMID:398723181 finding
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.record2021PMID:337120241 finding
Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.record2020PMID:316282121 finding
Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial.record2013PMID:236138251 finding