Endpoint
Catalase activity
An oxidoreductase that catalyzes the conversion of hydrogen peroxide to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in acatalasia.
CAT:outcome/catalase-activityreported in U/mL4 findings from 4 compounds
What moved it
How to read these marks4 findings · 4 compounds · 2 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| resveratrol | up | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| coenzyme Q10 | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| curcumin | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| melatonin | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
2 findings
resveratrol — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“In addition, compared to placebo, Supplementation with resveratrol significantly increased glutathione peroxidase levels (SMD = 0.38, 95%CI(0.03, 0.74), P = 0.04; Level of evidence:low) and catalase levels (SMD = 0.33, 95%CI(0.03, 0.63), P = 0.03; Level of evidence: low).”
Quoted verbatim from The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.. - Study
- meta-analysis
- Population
- patients with type 2 diabetes mellitus (T2DM)
The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.2024PMID:39872318Permalink
curcumin — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Serum concentrations of substance P (P<0·001) as well as activities of superoxide dismutase (P=0·02), glutathione peroxidase (P=0·006) and catalase (P<0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group.”
Quoted verbatim from Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial.. - Study
- RCT
- Duration
- 4 weeks
- Dose
- 1 g/d
- Population
- male Iranian veterans with sulphur mustard-induced chronic pruritus
Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial.2012PMID:22099425Permalink
Measured, no effect detected
2 findings
coenzyme Q10 — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“However, there were no significant effects of CoQ10 on NO, GSH concentrations, or CAT activity.”
Quoted verbatim from Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials.. - Study
- meta-analysis
- Population
- participants in randomized clinical trials of CoQ10 supplementation
Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials.2020PMID:32583356Permalink
melatonin — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Melatonin intake was not shown to significantly affect nitric oxide (NO) levels (SMD: -0.24; 95 % CI: -0.61, 0.14; I2 = 00.0 %) or catalase (CAT) activity (SMD: -1.38; 95 % CI: -1.42, 4.18; I2 = 96.6 %).”
Quoted verbatim from Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- unhealthy patients in randomized controlled trials of melatonin supplementation versus placebo
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.2020PMID:33007423Permalink
How it is measured
Catalase enzymatic activity in erythrocyte lysate, whole blood or serum, by rate of hydrogen peroxide decomposition followed spectrophotometrically at 240 nanometres.
Measured, not recorded
- Subject
- catalase activity
- Measurements
- 12 measurements
- Recorded as a finding
- No
Show what was measured
catalase activity
decreases, significantly reduced in curcumin group
Serum concentrations of substance P (P<0·001) as well as activities of superoxide dismutase (P=0·02), glutathione peroxidase (P=0·006) and catalase (P<0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group.
PMID:22099425 · both readings recorded this
catalase activity
increases
CuZnSOD and catalase activity increased with supplementation in young adult and aged animals
PMID:20705127 · one of two readings recorded this
catalase activity
increases
cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)
PMID:25009784 · one of two readings recorded this
catalase activity
increases
cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)
PMID:25009784 · one of two readings recorded this
catalase activity
increases
cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)
PMID:25009784 · one of two readings recorded this
catalase activity
increases
cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)
PMID:25009784 · one of two readings recorded this
catalase activity
increases
cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)
PMID:25009784 · one of two readings recorded this
catalase activity
increases
cerebral cortex (F = 27, df = 2), cerebellum(F = 34, df = 2), midbrain (F = 53, df = 2), pons-medulla (F = 14, df = 2), hippocampus (F = 25, df = 2) and hypothalamus (F = 50, df = 2)
PMID:25009784 · one of two readings recorded this
Catalase activity
increases
According to our studies, catalase, the oldest antioxidant enzyme discovered, can be activated by curcumin by 180%.
PMID:34946740 · one of two readings recorded this
catalase activity
increases, p = 0.05
The malondialdehyde levels were significantly higher and the activities of superoxide dismutase and catalase were lower in the cyclophosphamide group than in the cyclophosphamide+coenzyme q10 group (p<0.05)
PMID:38716935 · one of two readings recorded this
catalase activity
increases
CoQ-10 ameliorated oxidative stress by decreasing malondialdehyde levels and increasing catalase, glutathione peroxidase activities, and glutathione levels in the liver tissues
PMID:39449772 · one of two readings recorded this
catalase activity
decreases
In the diabetic group, the activity of glutathione peroxidase, catalase enzymes, and glutathione levels was decreased with an increase in malondialdehyde level
PMID:39449772 · one of two readings recorded this
Sources cited
4 papers
- Subject
- catalase activity
- Findings
- 4
- Papers
- 4
The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis.record2024PMID:398723181 finding
Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials.record2020PMID:325833561 finding
Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.record2020PMID:330074231 finding
Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial.record2012PMID:220994251 finding