Endpoint
Retinopathy of prematurity incidence
A bilateral retinopathy occurring in premature infants treated with excessively high concentrations of oxygen, characterized by vascular dilatation, proliferation, and tortuosity, edema, and retinal detachment, with ultimate conversion of the retina into a fibrous mass that can be seen as a dense retrolental membrane. Usually growth of the eye is arrested and may result in microophthalmia, and blindness may occur. (Dorland, 27th ed)
CAT:outcome/retinopathy-of-prematurity-incidencereported in risk ratio2 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · 2 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-cysteine | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Zn(2+) | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Every finding here is a null result.
Measured, no effect detected
2 findings
L-cysteine — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“No difference was found in the CYS and ISO groups with regards to the percent of subjects diagnosed with necrotizing enterocolitis (29% vs. 24%, p=1), intraventricular hemorrhage grade III and IV (19% vs. 24%, p=1), and need for laser treatment for retinopathy of prematurity (24% vs. 24%, p=1).”
Quoted verbatim from Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.. - Study
- RCT
- Dose
- cysteine-HCl 121 mg/kg/day in parenteral nutrition with sodium acetate 2 mEq/kg/day
- Population
- Critically ill neonates on mechanical ventilation and parenteral nutrition (SNAP > 10); event is ROP requiring laser treatment; comparator is isonitrogenous additional parenteral amino acids without cysteine
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.2016PMID:25139979Permalink
Zn(2+) — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Enteral zinc supplementation may have little or no effect on common morbidities such as bronchopulmonary dysplasia (RR 0.66, 95% CI 0.31 to 1.40, 1 study, 193 infants; low-certainty evidence), retinopathy of prematurity (RR 0.14, 95% CI 0.01 to 2.70, 1 study, 193 infants; low-certainty evidence), bacterial sepsis (RR 1.11, 95% CI 0.60 to 2.04, 2 studies, 293 infants; moderate-certainty evidence), or necrotising enterocolitis (RR 0.08, 95% CI 0.00 to 1.33, 1 study, 193 infants; low-certainty evidence).”
Quoted verbatim from Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates.. - Study
- meta-analysis
- Participants
- 193
- Population
- Hospitalised preterm infants given enteral zinc versus placebo or no supplementation; single study
Effect 0.14 risk ratio, 95% CI 0.01 to 2.7
Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates.2021PMID:33710626Permalink
How it is measured
Proportion of infants developing retinopathy of prematurity, by screening ophthalmoscopy against the International Classification. The stage threshold counted as an event — any stage, or severe disease requiring treatment — is recorded with each finding, since studies differ on it.
Sources cited
2 papers
- Subject
- retinopathy of prematurity incidence
- Findings
- 2
- Papers
- 2
Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates.record2021PMID:337106261 finding
Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.record2016PMID:251399791 finding