Endpoint
Circulating coenzyme Q10 concentration
CAT:outcome/circulating-coenzyme-q10reported in micrograms/mL2 findings from 1 compound
What moved it
How to read these marks2 findings · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| coenzyme Q10 | up | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
2 findings
coenzyme Q10 — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Pooled data did indicate that supplementation increased blood levels of coenzyme Q10 (MD 1.46; 95% CI 1.19 to 1.72, n = 112).”
Quoted verbatim from Coenzyme Q10 for heart failure.. - Study
- meta-analysis
- Participants
- 112
- Population
- patients with heart failure; Cochrane meta-analysis of 7 RCTs, 914 participants total, coenzyme Q10 versus placebo
Effect 1.46 mean difference, 95% CI 1.19 to 1.72
Coenzyme Q10 for heart failure.2014PMID:24049047Permalink
coenzyme Q10 — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“At 3 months, CoQ10 concentration was significantly higher in the CoQ10 group (3.85 μg/mL) compared with placebo (1.13 μg/mL); this difference was not present at 6 months.”
Quoted verbatim from No Effect of Coenzyme Q10 on Cognitive Function, Psychological Symptoms, and Health-related Outcomes in Schizophrenia and Schizoaffective Disorder: Results of a Randomized, Placebo-Controlled Trial.. - Study
- RCT
- Dose
- 300 mg/day
- Population
- adults with schizophrenia or schizoaffective disorder, CoQ10 300 mg/day vs placebo; measured at 3 months (difference not present at 6 months)
No Effect of Coenzyme Q10 on Cognitive Function, Psychological Symptoms, and Health-related Outcomes in Schizophrenia and Schizoaffective Disorder: Results of a Randomized, Placebo-Controlled Trial.2020PMID:33347024Permalink
How it is measured
Plasma or serum total coenzyme Q10 concentration by high-performance liquid chromatography with electrochemical or ultraviolet detection. Any lipid adjustment, and the time since the last dose, are recorded with each finding.
Sources cited
2 papers
- Subject
- circulating coenzyme q10 concentration
- Findings
- 2
- Papers
- 2