Endpoint
Physical function (pooled across scales)
CAT:outcome/physical-function-pooledreported in standardised mean difference2 findings from 2 compounds
What moved it
How to read these marks2 findings · 2 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| Collagen | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| glucosamine | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
2 findings
glucosamine — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“The pooled effect sizes for pain reduction and improvement in physical function were 0.41 (95% CI 0.21 to 0.60; p < 0.0001) and 0.46 (95% CI 0.27 to 0.66; p < 0.0001), respectively, in favor of glucosamine sulfate.”
Quoted verbatim from Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials.. - Study
- meta-analysis
- Dose
- glucosamine sulfate
- Population
- Knee osteoarthritis patients, long-term (at least 1 year) oral glucosamine sulfate trials, pooled
Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials.2005PMID:15855241Permalink
Collagen — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Collagen derivatives exerted small-to-moderate effects on pain alleviation (standardized mean difference [SMD] -0.35, 95% confidence interval [CI] -0.48 to -0.22, moderate certainty) and function improvement (SMD -0.31, 95%CI -0.41 to -0.22, high certainty) compared with the control.”
Quoted verbatim from Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis.. - Study
- meta-analysis
- Population
- patients with osteoarthritis
Efficacy and safety of collagen derivatives for osteoarthritis: A trial sequential meta-analysis.2024PMID:38218227Permalink
How it is measured
Standardised mean difference for physical function pooled across trials, the source instrument not held constant. The sign convention of the pooled estimate is recorded with each finding and is not optional.
Sources cited
2 papers
- Subject
- physical function (pooled across scales)
- Findings
- 2
- Papers
- 2