Endpoint
Serum paraoxonase-1 (PON1) activity
An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).
CAT:outcome/paraoxonase-1-activityreported in U/mL
How it is measured
Serum paraoxonase-1 enzymatic activity measured by hydrolysis of a defined substrate - paraoxonase activity with paraoxon, or arylesterase activity with phenyl acetate - expressed as units per mL. The substrate is recorded with each finding; the two activities reflect different properties of the enzyme and are affected differently by the PON1 Q192R polymorphism.