Endpoint
Osteoarthritis pain (pooled across scales)
CAT:outcome/osteoarthritis-pain-pooledreported in standardised mean difference2 findings from 1 compound
What moved it
How to read these marks2 findings · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| glucosamine | down | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
2 findings
glucosamine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Glucosamine moderately reduced pain (SMD -0.51 [95% CI -0.72, -0.30]), although a high level of between-trial inconsistency was observed (I(2) = 88%).”
Quoted verbatim from Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials.. - Study
- meta-analysis
- Population
- Osteoarthritis patients, pooled across 25 placebo-controlled glucosamine trials
Effect -0.51 standardised mean difference, 95% CI -0.72 to -0.3
Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials.2014PMID:24905534Permalink
glucosamine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“The pooled effect sizes for pain reduction and improvement in physical function were 0.41 (95% CI 0.21 to 0.60; p < 0.0001) and 0.46 (95% CI 0.27 to 0.66; p < 0.0001), respectively, in favor of glucosamine sulfate.”
Quoted verbatim from Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials.. - Study
- meta-analysis
- Dose
- glucosamine sulfate
- Population
- Knee osteoarthritis patients, long-term (at least 1 year) oral glucosamine sulfate trials, pooled
Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials.2005PMID:15855241Permalink
How it is measured
Standardised mean difference for osteoarthritis pain pooled across whichever pain instrument each constituent trial used, the mixture of instruments differing between meta-analyses. The defining property of this endpoint is that no single instrument is held constant across the pooled estimate.
Sources cited
2 papers
- Subject
- osteoarthritis pain (pooled across scales)
- Findings
- 2
- Papers
- 2
Risk of bias and brand explain the observed inconsistency in trials on glucosamine for symptomatic relief of osteoarthritis: a meta-analysis of placebo-controlled trials.record2014PMID:249055341 finding
Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials.record2005PMID:158552411 finding