Cross-linking adverse event incidence

Method

Proportion of eyes treated with corneal collagen cross-linking recording any complication or adverse event during follow-up -- corneal haze, delayed epithelial healing, infiltrate, sterile keratitis or endothelial cell loss. Follow-up duration recorded on the edge.

The method is part of the endpoint identity. Studies measuring the same quantity by a different method are held as separate endpoints.

Notes

Will be confused with intraoperative and postoperative patient COMFORT, which PMID 41661382 reports as better with the iontophoresis-assisted technique but never quantifies on a named scale. Comfort is a symptom rating, complication frequency is a count of clinical events, and no comfort claim may be mapped here. Also narrower than a generic any-adverse-event node: this counts ocular events attributable to the procedure, not systemic events, so the two must not be pooled into a single safety estimate.