Endpoint
Organism lifespan
CAT:outcome/organism-lifespanreported in hazard ratio6 findings from 4 compounds
What moved it
How to read these marks6 findings · 4 compounds · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-ascorbic acid | down | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| Camellia sinensis | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| sodium benzoate | down | 2 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
| resveratrol | up | 1 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
Reported to move it
6 findings
L-ascorbic acid — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Treatment with 1 mM vitamin C also significantly shortened the lifespan of both isp-1 and nuo-6 mutants without affecting the wild type (Table S1).”
Quoted verbatim from A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.. - Study
- animal · not in humans
- Dose
- 1 mM in nematode growth medium
- Population
- Long-lived Caenorhabditis elegans mitochondrial mutants isp-1(qm150) and nuo-6(qm200), raised from hatching on plates containing 1 mM vitamin C; wild-type animals were reported unaffected
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.2010PMID:21151885Permalink
Camellia sinensis — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“We treated wild-type worms with three types of oolong tea extracts (QFT, NFT, and CFT), which resulted in a dose dependent increase in mean lifespan relative to mock-treated controls (Table S1).”
Quoted verbatim from Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan.. - Study
- animal · not in humans
- Dose
- 100 ug/ml chosen for subsequent experiments; mean lifespan did not rise further at 200 ug/ml
- Population
- wild-type (N2) Caenorhabditis elegans, treated from larval stage 4 (L4) onward, at 20 C; three oolong tea extracts pooled in the sentence
Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan.2022PMID:34637108Permalink
resveratrol — increases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Overall, our results indicate that resveratrol acts as a life-extending agent.”
Quoted verbatim from The effect of resveratrol on longevity across species: a meta-analysis.. - Study
- animal · not in humans
- Population
- survival data pooled from 19 published papers across six model species -- yeast, nematodes, mice, fruitflies, Mexican fruitflies and turquoise killifish; abstract only
The effect of resveratrol on longevity across species: a meta-analysis.2012PMID:22718956Permalink
sodium benzoate — decreases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×1“We observed that SB (2.0 and 5.0 mg/5 g diet) decreased the survival of D. melanogaster.”
Quoted verbatim from Toxicological assessment of sodium benzoate in Drosophila melanogaster.. - Study
- animal · not in humans
- Duration
- 3 weeks
- Dose
- 2.0-5.0 mg/5 g diet, oral, 21 days
- Population
- adult wild-type Canton S Drosophila melanogaster fed SB
Toxicological assessment of sodium benzoate in Drosophila melanogaster.2024PMID:37986221Permalink
sodium benzoate — decreases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×1“Lifespan analysis also demonstrated that SB significantly reduced lifespan in wild-type worms, even at low concentrations.”
Quoted verbatim from Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.. - Study
- animal · not in humans
- Dose
- 0.0004-0.1% SB, in liquid culture or on NGM agar
- Population
- wild-type Caenorhabditis elegans exposed to SB concentrations 0.0004-0.1%
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.2024PMID:39519584Permalink
L-ascorbic acid — decreases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Findingreplicated ×1“VitC however produced only a very mild lifespan shortening at the lower concentration tested (5 mm).”
Quoted verbatim from Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.. - Study
- animal · not in humans
- Dose
- 5 mM in growth medium
- Population
- Wild-type Caenorhabditis elegans on nematode growth medium plates containing DMSO, vitamin C at the lower tested concentration (5 mM) only; mean lifespan versus untreated control
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.2017PMID:27683245Permalink
How it is measured
Elapsed time from the start of observation until death in a model organism, read from a survival curve as median or maximum lifespan, or as the percentage change in either. Species and life stage at first exposure are recorded with each finding and are not optional: a yeast replicative count, a nematode's days of adulthood and a mouse's months are the same construct on incomparable clocks, and a single estimate spanning them describes the combining as much as the exposure. Named in this literature as lifespan extension, life extension, longevity, or a life-extending effect.
Sources cited
6 papers
- Subject
- organism lifespan
- Findings
- 6
- Papers
- 6
Sodium Benzoate Induces Fat Accumulation and Reduces Lifespan via the SKN-1/Nrf2 Signaling Pathway: Evidence from the Caenorhabditis elegans Model.record2024PMID:395195841 finding
Toxicological assessment of sodium benzoate in Drosophila melanogaster.record2024PMID:379862211 finding
Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan.record2022PMID:346371081 finding
Antioxidants reveal an inverted U-shaped dose-response relationship between reactive oxygen species levels and the rate of aging in Caenorhabditis elegans.record2017PMID:276832451 finding
The effect of resveratrol on longevity across species: a meta-analysis.record2012PMID:227189561 finding
A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.record2010PMID:211518851 finding