Endpoint
Isometric peak force
CAT:outcome/isometric-peak-forcereported in N5 findings from 3 compounds
What moved it
How to read these marks5 findings · 3 compounds · 4 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| caffeine | no effect | 2 | Evidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited. |
| creatine | no effect 1 · up 1 | 2 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| nitrate | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
creatine — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In trials with 138 participants with muscular dystrophies treated with creatine, there was a significant increase in maximum voluntary contraction in the creatine group compared to placebo, with a weighted mean difference of 8.47% (95% confidence intervals 3.55 to 13.38).”
Quoted verbatim from Creatine for treating muscle disorders.. - Study
- meta-analysis
- Participants
- 138
- Population
- People with muscular dystrophies
Creatine for treating muscle disorders.2007PMID:17253521Permalink
Measured, no effect detected
4 findings
caffeine — no detected effect on
LimitedEvidence strength: limited. Human evidence with several recorded weaknesses, or a design that tops out at limited.FindingNull resultreplicated ×1“No significant differences were detected in maximal isometric voluntary contraction strength of the right knee (MVCLEG) among any treatment (AMPLAC, AMCAFF and PMPLAC).”
Quoted verbatim from Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men.. - Study
- crossover
- Participants
- 12
- Dose
- 3 mg/kg caffeine, ingested 60 min before testing (AMCAFF morning trial)
- Population
- highly resistance-trained men
Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men.2012PMID:22496767Permalink
caffeine — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×1“There was no effect of caffeine on 40-Hz stimulation strength nor was there an effect on maximal voluntary contraction or peak twitch torque.”
Quoted verbatim from Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers.. - Study
- RCT
- Participants
- 12
- Dose
- 6 mg/kg caffeine, ~100 min before testing
- Population
- healthy male habitual and nonhabitual caffeine consumers
Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers.2000PMID:11053318Permalink
nitrate — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“There was no clear effect of NO3- on isometric MVC (SMD = 0.03, P = 0.758).”
Quoted verbatim from The Effect of Dietary Nitrate on the Contractile Properties of Human Skeletal Muscle: A Systematic Review and Meta-Analysis.. - Study
- meta-analysis
- Population
- healthy adults
The Effect of Dietary Nitrate on the Contractile Properties of Human Skeletal Muscle: A Systematic Review and Meta-Analysis.2023PMID:35604074Permalink
creatine — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“In trials with 33 participants with metabolic myopathies treated with creatine, there was no significant difference in maximum voluntary contraction between the creatine and placebo group (weighted mean difference -2.26%, confidence intervals -6.29 to 1.78).”
Quoted verbatim from Creatine for treating muscle disorders.. - Study
- meta-analysis
- Participants
- 33
- Population
- People with metabolic myopathies
Creatine for treating muscle disorders.2007PMID:17253521Permalink
How it is measured
Peak force during a maximal voluntary isometric contraction against an immovable resistance. Joint angle and apparatus recorded with each finding.
Sources cited
4 papers
- Subject
- isometric peak force
- Findings
- 5
- Papers
- 4
The Effect of Dietary Nitrate on the Contractile Properties of Human Skeletal Muscle: A Systematic Review and Meta-Analysis.record2023PMID:356040741 finding
Caffeine ingestion reverses the circadian rhythm effects on neuromuscular performance in highly resistance-trained men.record2012PMID:224967671 finding
Creatine for treating muscle disorders.record2007PMID:172535212 findings
Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers.record2000PMID:110533181 finding