Endpoint
Superoxide dismutase activity
An oxidoreductase that catalyzes the reaction between superoxides and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide.
CAT:outcome/superoxide-dismutase-activityreported in U/mL9 findings from 6 compounds
What moved it
How to read these marks9 findings · 6 compounds · 5 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| curcumin | up 3 · no effect 1 | 4 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| coenzyme Q10 | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Ginkgo biloba | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| Vitis vinifera | no effect | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| resveratrol | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
| L-glutamine | up | 1 | Evidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited. |
Reported to move it
4 findings
curcumin — increases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Findingreplicated ×2“Compared to the placebo group, curcumin supplementation significantly enhanced antioxidant defenses, as evidenced by increased levels of total antioxidant capacity (TAC), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activity at 3, 6, 9, and 12 months.”
Quoted verbatim from Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.. - Study
- RCT
- Duration
- 12 months
- Dose
- Oral ethanolic Curcuma longa rhizome extract standardised to 75-85% total curcuminoids, 250 mg curcuminoids per capsule, three capsules twice daily (1500 mg curcuminoids/day) for 12 months
- Population
- Obese adults with type 2 diabetes mellitus managed on metformin (age >=35 y, BMI >=23 kg/m2, HbA1c <6.5%), Nakhon Nayok, Thailand; 227 randomised, per-protocol analysis and the analysed count is not reported in the paper; secondary endpoint (declared primary outcome: liver steatosis by controlled attenuation parameter on transient elastography); SOD by RANSOD colorimetric assay
Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.2025PMID:41096556Industry fundedPermalink
curcumin — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“There was a significant reduction in circulating MDA concentrations (SMD = -0.769, 95% CI: -1.059 to -0.478) and a significant increase in SOD activity (SMD = 1.084, 95% CI: 0.487 to 1.680) following curcumin supplementation.”
Quoted verbatim from Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress.. - Study
- meta-analysis
- Population
- adults in RCTs of curcumin supplementation (>=4 weeks) assessing oxidative-stress biomarkers
Effect 1.084 standardised mean difference, 95% CI 0.487 to 1.68
Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress.2018PMID:30527253Permalink
curcumin — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×2“Curcuminoids supplementation also significantly increased serum superoxide dismutase (SOD) activity.”
Quoted verbatim from Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes.. - Study
- RCT
- Participants
- 100
- Duration
- 3 months
- Population
- adults with type 2 diabetes, reassessed from a prior 3-month curcuminoids RCT cohort
Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes.2014PMID:25374024Permalink
L-glutamine — increases
InsufficientEvidence strength: insufficient. Mechanistic inference, no evidence found, or evidence weakened below very limited.Finding“Concentrations of superoxide dismutase were significantly lower in all the PCOS groups (P < 0.01) compared to the control group, and increased significantly with the supplementation of 0.5 g/kg glutamine (P < 0.01).”
Quoted verbatim from The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.. - Study
- animal · not in humans
- Dose
- 0.5 g/kg, intraperitoneal, twice on the morning after the last DHEA injection
- Population
- Female Sprague-Dawley rats, DHEA-induced PCOS model, 0.5 g/kg glutamine dose
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.2020PMID:32386521Permalink
Measured, no effect detected
5 findings
Ginkgo biloba — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“The activities of SOD and CAT were not significantly affected by supplementation with Ginkgo biloba extract, although SOD activities recorded in both groups at rest and post-exercise were slightly higher compared to the corresponding baseline values.”
Quoted verbatim from Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men.. - Study
- RCT
- Participants
- 18
- Duration
- 6 weeks
- Dose
- 160 mg/day (two 80 mg capsules once daily after breakfast) for six weeks
- Population
- healthy physically active young men, physical education students, aged 20-24 years
Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men.2017PMID:28933745Permalink
coenzyme Q10 — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“As shown in Table 2, the between-group comparison revealed no significant difference between CoQ10 and placebo groups at the end of the study for MDA (P = 0.692), SOD activity (P = 0.633), and TAC (P = 0.865).”
Quoted verbatim from Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.. - Study
- RCT
- Participants
- 52
- Duration
- 10 days
- Dose
- 100 mg three times a day after meals, total 300 mg/day
- Population
- Adults aged 18-65 with 20-60% total body surface area burns admitted to a burn ICU in Isfahan, Iran, all receiving routine burn care and the unit's standard vitamin, selenium, zinc and B-complex supplementation in both arms; primary outcome.
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.2024PMID:38431600Permalink
Vitis vinifera — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull result“According to the data meta-analysis, some studies showed that GPCP had no significant effect on SOD levels (WMD = 0.003 U/mgHb; 95% CI: − 0.002, 0.007; P = 0.29).”
Quoted verbatim from The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- Adults in pooled randomized trials of grape products containing polyphenols (grape extract, grape powder, juice, raisin, resveratrol, red wine), healthy and unhealthy participants combined
Effect 0.003 mean difference, 95% CI -0.002 to 0.007
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.2021PMID:33712024Industry fundedPermalink
curcumin — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Though, curcumin supplementation had no significant effect on tumor necrosis factor-alpha (SMD -1.62; 95% CI [-3.60, 0.36]; p = 0.10) and superoxide dismutase levels (SMD 0.34; 95% CI [-1.06, 1.74], p = 0.63).”
Quoted verbatim from The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.. - Study
- meta-analysis
- Population
- adults
Effect 0.34 standardised mean difference, 95% CI -1.06 to 1.74
The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.2019PMID:30402990Permalink
resveratrol — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“Collectively, our findings of available RCTs did no show any benefit of resveratrol supplementation on SOD, CAT and GPx except for TAC.”
Quoted verbatim from Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.. - Study
- meta-analysis
- Population
- adults in randomised controlled trials of resveratrol supplementation
Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.2020PMID:31628212Permalink
How it is measured
Superoxide dismutase enzymatic activity in erythrocyte lysate, whole blood or serum, by inhibition-of-substrate-oxidation assay, expressed per gram haemoglobin or per millilitre as stated with each finding.
Measured, not recorded
- Subject
- superoxide dismutase activity
- Measurements
- 10 measurements
- Recorded as a finding
- No
Show what was measured
superoxide dismutase activity
decreases, significantly reduced in curcumin group, p = 0.02
Serum concentrations of substance P (P<0·001) as well as activities of superoxide dismutase (P=0·02), glutathione peroxidase (P=0·006) and catalase (P<0·001) were significantly reduced in the curcumin group, while no significant change was observed in the placebo group.
PMID:22099425 · both readings recorded this
Superoxide dismutase activity
no effect, p = 0.05, n = 87
differences in the mean levels of activities of SOD and GPX, two antioxidant enzymes, among three groups of the study were not significant (P > 0.05 in all cases)
PMID:28074795 · one of two readings recorded this
superoxide dismutase activity
no effect
Superoxide dismutase activity was significantly elevated after exercise (p = 0.002) in placebo but not AA
PMID:30665439 · one of two readings recorded this
superoxide dismutase activity
increases, p = 0.002
Superoxide dismutase activity was significantly elevated after exercise (p = 0.002) in placebo but not AA
PMID:30665439 · one of two readings recorded this
Superoxide dismutase activity
increases
The highest SOD activity was noted in calli grown on the medium with Nar, where it was almost 2.5 times higher than the control variant
PMID:38257387 · one of two readings recorded this
Superoxide dismutase activity
no effect
As for the calli exposed to Phe, the enzyme activity was statistically equal to the control values
PMID:38257387 · one of two readings recorded this
superoxide dismutase activity
increases, p = 0.05
The malondialdehyde levels were significantly higher and the activities of superoxide dismutase and catalase were lower in the cyclophosphamide group than in the cyclophosphamide+coenzyme q10 group (p<0.05)
PMID:38716935 · one of two readings recorded this
Superoxide dismutase activity
increases, p = 0.001
Total antioxidant status, glutathione peroxidase activity, and superoxide dismutase activity were elevated in the curcumin group, whereas malondialdehyde levels were greater in the placebo group (p < 0.001 for all).
PMID:39125295 · one of two readings recorded this
superoxide dismutase activity
increases
superoxide dismutase activity (WMD:20.51 u/L; 95%CI: 7.35, 33.67; I2 = 95.4%)
PMID:40538540 · one of two readings recorded this
superoxide dismutase activity
increases
Superoxide dismutase activity was also significantly higher in the curcumin group at 3, 6, 9, and 12 months
PMID:40573083 · one of two readings recorded this
Sources cited
9 papers
- Subject
- superoxide dismutase activity
- Findings
- 9
- Papers
- 9
Curcumin Attenuates Liver Steatosis via Antioxidant and Anti-Inflammatory Pathways in Obese Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.record2025PMID:410965561 finding
Coenzyme Q10 supplementation in burn patients: a double-blind placebo-controlled randomized clinical trial.record2024PMID:384316001 finding
The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials.record2021PMID:337120241 finding
The effect of glutamine on Dehydroepiandrosterone-induced polycystic ovary syndrome rats.record2020PMID:323865211 finding
Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.record2020PMID:316282121 finding
The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.record2019PMID:304029901 finding
Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress.record2018PMID:305272531 finding
Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in Physically Active Men.record2017PMID:289337451 finding
Curcuminoids Target Decreasing Serum Adipocyte-fatty Acid Binding Protein Levels in Their Glucose-lowering Effect in Patients with Type 2 Diabetes.record2014PMID:253740241 finding