Endpoint
Serum thyroid peroxidase antibody (TPOAb) titre
CAT:outcome/serum-tpo-antibody-titrereported in U/mL1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| selenium atom | down | 1 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
Reported to move it
1 finding
selenium atom — decreases
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.Finding“We found that the TPOAb levels of HT patients who received Se supplementation decreased significantly after 3 months (SMD = −0.46, 95% CI: −0.74 to −0.18, P =.001) and after 6 months (SMD = −0.80, 95% CI: −1.38 to −0.21, P =.008).”
Quoted verbatim from Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.. - Study
- meta-analysis
- Dose
- typically 200 μg/d
- Population
- Adults with Hashimoto thyroiditis, with or without levothyroxine; selenium (selenomethionine, selenoyeast or sodium selenate) against placebo, no treatment or levothyroxine alone; 6-month timepoint estimate recorded
Effect -0.8 standardised mean difference, 95% CI -1.38 to -0.21
Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.2025PMID:40898469Permalink
How it is measured
Thyroid peroxidase autoantibody (anti-TPO, TPOAb, TPO-Ab) concentration or titre in serum by clinical immunoassay, in U/mL or IU/mL as reported. The assay and the unit are recorded with each finding, since manufacturers' reference ranges and units differ.
Sources cited
1 paper
- Subject
- serum thyroid peroxidase antibody (tpoab) titre
- Findings
- 1
- Papers
- 1