Endpoint
Infectious complication rate
CAT:outcome/infectious-complication-ratereported in event rate6 findings from 2 compounds
What moved it
How to read these marks6 findings · 2 compounds · 3 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-glutamine | no effect 3 · down 2 | 5 | Evidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers. |
| L-arginine | down | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
3 findings
L-arginine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“Meta-analysis showed that the L-arginine supplement group had a significantly greater CD4⁺ T-cell proliferation response (MD 5.03; 95% CI 1.11, 8.95; p<0.05), and that the incidence of infectious complications was lower (OR 0.40; 95% CI 0.17, 0.95; p<0.05) than control.”
Quoted verbatim from Effect of L-arginine on immune function: a meta-analysis.. - Study
- meta-analysis
- Population
- patients
Effect 0.4 odds ratio, 95% CI 0.17 to 0.95
Effect of L-arginine on immune function: a meta-analysis.2014PMID:25164444Permalink
L-glutamine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“The results showed a significant decrease in the infectious complication rates of patients undergoing abdominal surgery receiving GLN-PN (risk ratio [RR], 0.48; 95% confidence interval [CI], 0.32 to 0.72; P = 0.0004).”
Quoted verbatim from The impact of perioperative glutamine-supplemented parenteral nutrition on outcomes of patients undergoing abdominal surgery: a meta-analysis of randomized clinical trials.. - Study
- meta-analysis
- Population
- patients undergoing abdominal surgery receiving glutamine-supplemented parenteral nutrition
The impact of perioperative glutamine-supplemented parenteral nutrition on outcomes of patients undergoing abdominal surgery: a meta-analysis of randomized clinical trials.2013PMID:23635587Permalink
L-glutamine — decreases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Findingreplicated ×1“Glutamine supplementation was also associated with a lower rate of infectious complications (RR, 0.81; 95% CI, 0.64-1.00) and a shorter hospital stay (-2.6 days; 95% CI, -4.5 to -0.7).”
Quoted verbatim from Glutamine supplementation in serious illness: a systematic review of the evidence.. - Study
- meta-analysis
- Population
- surgical and critically ill adult patients (pooled meta-analysis of 14 randomised trials, various glutamine doses and routes)
Effect 0.81 risk ratio, 95% CI 0.64 to 1
Glutamine supplementation in serious illness: a systematic review of the evidence.2002PMID:12352035Permalink
Measured, no effect detected
3 findings
L-glutamine — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×2“GLN supplementation did not affect overall morbidity (RR = 0.84, 95% CI 0.51 to 1.36; p = 0.473) and infectious morbidity (RR = 0.64; 95% CI = 0.38 to 1.07; p = 0.087).”
Quoted verbatim from Effect of glutamine dipeptide supplementation on primary outcomes for elective major surgery: systematic review and meta-analysis.. - Study
- meta-analysis
- Population
- patients undergoing major elective abdominal operations
Effect of glutamine dipeptide supplementation on primary outcomes for elective major surgery: systematic review and meta-analysis.2015PMID:25584966Permalink
L-glutamine — no detected effect on
ModerateEvidence strength: moderate. Human evidence with one recorded weakness, or capped at moderate by its design or by unread numbers.FindingNull resultreplicated ×2“When the four studies in which the researchers reported infectious complications were aggregated, enteral GLN supplementation was not associated with a reduction in infectious complications (RR 0.93, 95 % CI 0.79–1.10, p =0.39; heterogeneity I2 = 0 %) (Fig..”
Quoted verbatim from Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis.. - Study
- meta-analysis
- Participants
- 776
- Population
- Adult critically ill ICU patients given enteral glutamine against an isonitrogenous control; secondary endpoint (primary was hospital mortality); 4 pooled trials; infection defined by each source trial
Effect 0.93 risk ratio, 95% CI 0.79 to 1.1
Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis.2015PMID:26283217Permalink
L-glutamine — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull resultreplicated ×2“We observed no significant effect of glutamine supplementation on overall mortality (RR, 0.65, 95% CI, 0.33-1.28; p = 0.21), infectious complications (RR, 0.83; 95% CI, 0.63-1.09; p = 0.18), or other secondary outcomes.”
Quoted verbatim from The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis.. - Study
- meta-analysis
- Population
- Severe adult burn patients receiving glutamine supplementation, enteral or IV route pooled (meta-analysis of 10 RCTs).
The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis.2023PMID:37114912Permalink
How it is measured
Proportion of patients developing an infectious complication as defined by each source's own criteria. The case definition and the clinical setting are recorded with each finding, since postoperative, burn and critical-care definitions do not overlap.
Measured, not recorded
- Subject
- infectious complication rate
- Measurements
- 2 measurements
- Recorded as a finding
- No
Show what was measured
infectious complication rate
decreases, p = 0.02
The overall effect indicated a significant decrease in the infectious complication rates of surgical patients receiving GLN-PN (risk ratio = 0.69; 95% CI 0.50, 0.95; z = 2.26; P = .02)
PMID:20852180 · one of two readings recorded this
infectious complication rate
decreases, p = 0.0004
a significant decrease in the infectious complication rates of patients undergoing abdominal surgery receiving GLN-PN (risk ratio [RR], 0.48; 95% confidence interval [CI], 0.32 to 0.72; P = 0.0004)
PMID:23635587 · one of two readings recorded this
Sources cited
6 papers
- Subject
- infectious complication rate
- Findings
- 6
- Papers
- 6
The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis.record2023PMID:371149121 finding
Effect of glutamine dipeptide supplementation on primary outcomes for elective major surgery: systematic review and meta-analysis.record2015PMID:255849661 finding
Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis.record2015PMID:262832171 finding
Effect of L-arginine on immune function: a meta-analysis.record2014PMID:251644441 finding
The impact of perioperative glutamine-supplemented parenteral nutrition on outcomes of patients undergoing abdominal surgery: a meta-analysis of randomized clinical trials.record2013PMID:236355871 finding
Glutamine supplementation in serious illness: a systematic review of the evidence.record2002PMID:123520351 finding