Endpoint
Plasma citrulline concentration
CAT:outcome/plasma-citrulline-concentrationreported in umol/L1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| L-glutamine | up | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Reported to move it
1 finding
L-glutamine — increases
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.Finding“In plasma (Table 5), both citrulline and proline levels were significantly higher in glutamine-supplemented rats than in controls.”
Quoted verbatim from Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.. - Study
- animal · not in humans
- Dose
- glutamine in drinking water 7 consecutive days a month for 10 months, 20% of dietary protein (about 0.8 g/rat/day)
- Population
- Very old (27-month) female Wistar rats given intermittent oral glutamine for 10 months versus water-only controls
Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.2014PMID:25389959Permalink
How it is measured
Concentration of citrulline in plasma or serum by amino acid analyser, HPLC or LC-MS/MS, used as a marker of enterocyte mass or of citrulline supplementation exposure. Fasting state and time since the last dose are recorded with each finding.
Sources cited
1 paper
- Subject
- plasma citrulline concentration
- Findings
- 1
- Papers
- 1