Endpoint
Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) score
CAT:outcome/adas-cog-scorereported in score (0-70)1 finding from 1 compound
What moved it
How to read these marks1 finding · 1 compound · 1 null · by evidence strength
| Compound | Direction | Findings | Strongest evidence |
|---|---|---|---|
| nicotinamide | no effect | 1 | Evidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence. |
Every finding here is a null result.
Measured, no effect detected
1 finding
nicotinamide — no detected effect on
Very limitedEvidence strength: very limited. Human evidence with major recorded weaknesses, or non-human, uncontrolled or unverified evidence.FindingNull result“At week 48, nicotinamide-treated participants experienced less decline on CDR-SB (mixed-effect model with repeated measures; estimate = -1.42, SE = 0.65; p = 0.03 unadjusted for multiple comparisons), without significant differences in cognitive (ADAS-cog; estimate = -1.93, SE = 1.93; p = 0.32) or functional (ADCS-ADL-MCI; estimate = -3.10, SE = 1.86; p = 0.10) outcomes.”
Quoted verbatim from Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease.. - Study
- RCT
- Duration
- 11 months
- Dose
- 1,500 mg twice daily
- Population
- Adults with mild cognitive impairment or mild dementia with CSF biomarker-confirmed Alzheimer disease, nicotinamide versus placebo
Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease.2025PMID:39671543Permalink
How it is measured
Total score on the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), administered by a trained rater.
Sources cited
1 paper
- Subject
- alzheimer's disease assessment scale-cognitive subscale (adas-cog) score
- Findings
- 1
- Papers
- 1