Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Pathways Processes Anatomy Cell types Organisms Materials Assessments

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Graded findings 28 Every routed compound 2,915

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197 entities, 482 connections

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Claim

Relationship

Evidence, at least

Reaches, in the body

Every placement in the body is an inference: a compound is placed in a region because a transporter known to carry it is expressed in a tissue of that region, not because any source reports it arriving there. Filtering here filters by hypothesis.

Or open the atlas, where these placements are drawn on the body

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Start with a name, a kind, or a body system. 25,278 more nodes sit behind the findings drawn here.

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How to read the figure

What is drawn

25,306 nodes · 3,213 compounds · 28 with a graded finding · 2,915 with a route · drawing 28 · hub metabolites excluded by the projection

How the field reads

Distance from the middle is the layer, never the grade. What a graded finding touches is in the middle, what that reaches is around it, and the rest of the reference layer is outside that.
From far away the reference layer is a field. A cell's tone is how many relationships touch it, never their strength. Zoom in to draw its runs.
A pinned node lights its rings. What touches it comes up in the accent, in place; the field recedes. Each ring further out is lit a little less.
Nothing about a node's size or brightness is volume. How many relations name it is said in the inspector, in words.

Shape and colour are the kind of thing

Compound
Protein
Measured endpoint
Pathway
Process
Anatomy
Cell type
Organism
Material
Assessment
Gene
Phenotype
Variant

Every node is one size. How many relations name it is said in the inspector, never drawn.

Line weight and dash are the grade

A · Well established
B · Likely
C · Suggestive
D · Preliminary
F · Speculative

A gap is a claim nobody made

Finding — a source reports it
Hypothesis — a path through a shared intermediate

A gapped run is a line that does not complete, because the connection is not asserted.

Selection

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Entities

197

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Edge list

197 entities, 482 connections: 399 findings and 83 inferred.

Capped at 6 proteins per compound (238 omitted); hub metabolites excluded.

Inferred

Derived from Rhea, Reactome, UniProt, ChEBI and Gene Ontology. These are established reactions, but no source reports the connection being drawn from them, and nothing here carries a grade.

all-cis-5,8,11,14,17-icosapentaenoic acidHOMA-IROutcomeFindinggrade A
methylene blueAll-cause mortalityOutcomeFindinggrade A
methylene blueIntensive care unit length of stayOutcomeFindinggrade A
coenzyme Q10C-reactive protein concentrationOutcomeFindinggrade A
resveratrolHDL cholesterolOutcomeFindinggrade A
coenzyme Q10Erythrocyte sedimentation rateOutcomeFindinggrade A
coenzyme Q10Superoxide dismutase activityOutcomeFindinggrade A
all-cis-5,8,11,14,17-icosapentaenoic acidSerum albuminOutcomeFindinggrade A
resveratrolTotal cholesterol (TC)OutcomeFindinggrade A
resveratrolFat massOutcomeFindinggrade A
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade A
resveratrolClinical pregnancy rateOutcomeFindinggrade A

Show the remaining 470 connections

coenzyme Q10Intensive care unit length of stayOutcomeFindinggrade A
resveratrolHDL cholesterolOutcomeFindinggrade A
coenzyme Q10All-cause mortalityOutcomeFindinggrade A
resveratrolTriglyceridesOutcomeFindinggrade A
L-glutamineCD4/CD8 ratioOutcomeFindinggrade A
L-glutamineAll-cause mortalityOutcomeFindinggrade A
creatineCountermovement jump heightOutcomeFindinggrade A
methylene blueHospital length of stayOutcomeFindinggrade A
resveratrolTotal testosteroneOutcomeFindinggrade A
creatineLean body massOutcomeFindinggrade B
melatoninGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
creatineSerum creatinine concentrationOutcomeFindinggrade B
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade B
curcuminDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
melatoninBody mass indexOutcomeFindinggrade B
curcuminBody mass indexOutcomeFindinggrade B
all-cis-5,8,11,14,17-icosapentaenoic acidErythrocyte sedimentation rateOutcomeFindinggrade B
melatoninTotal antioxidant capacityOutcomeFindinggrade B
berberineTotal cholesterol (TC)OutcomeFindinggrade B
berberineAdverse reaction incidence (unstandardised)OutcomeFindinggrade B
caffeineTime-trial completion timeOutcomeFindinggrade B
nitrateColorectal cancer incidenceOutcomeFindinggrade B
creatineOne-repetition maximum strengthOutcomeFindinggrade B
creatineC-reactive protein concentrationOutcomeFindinggrade B
creatineSerum creatinine concentrationOutcomeFindinggrade B
creatineLower-body muscular strength (pooled composite)OutcomeFindinggrade B
curcuminSerum alkaline phosphataseOutcomeFindinggrade B
L-glutamineInfectious complication rateOutcomeFindinggrade B
nitrateMaximal oxygen uptakeOutcomeFindinggrade B
nitrateUrinary bladder cancer incidenceOutcomeFindinggrade B
nitrateMean power outputOutcomeFindinggrade B
nitratePlasma nitrate concentrationOutcomeFindinggrade B
creatineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
methylene blueDuration of mechanical ventilationOutcomeFindinggrade B
creatineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
L-glutamineC-reactive protein concentrationOutcomeFindinggrade B
caffeineLower-body muscular strength (pooled composite)OutcomeFindinggrade B
curcuminInterleukin-6 concentrationOutcomeFindinggrade B
luteinWorking memory performanceOutcomeFindinggrade B
L-arginineCD4+ T cell countOutcomeFindinggrade B
curcuminErythrocyte sedimentation rateOutcomeFindinggrade B
berberineGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
curcuminDisease Activity Score in 28 joints (DAS-28)OutcomeFindinggrade B
resveratrolC-reactive protein concentrationOutcomeFindinggrade B
nitrateBody mass indexOutcomeFindinggrade B
magnesium(2+)Serum magnesium concentrationOutcomeFindinggrade B
resveratrolMalondialdehyde (circulating)OutcomeFindinggrade B
methylene blueHospital length of stayOutcomeFindinggrade B
caffeineOne-repetition maximum strengthOutcomeFindinggrade B
curcuminSystolic blood pressure (setting unspecified)OutcomeFindinggrade B
L-glutamineGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
L-citrullineFlow-mediated dilationOutcomeFindinggrade B
magnesium(2+)Body mass indexOutcomeFindinggrade B
caffeineAdverse reaction incidence (unstandardised)OutcomeFindinggrade B
coenzyme Q10Fasting blood glucoseOutcomeFindinggrade B
coenzyme Q10Clinical pregnancy rateOutcomeFindinggrade B
melatoninFasting blood glucoseOutcomeFindinggrade B
melatoninMalondialdehyde (circulating)OutcomeFindinggrade B
melatoninTotal antioxidant capacityOutcomeFindinggrade B
caffeineRating of perceived exertionOutcomeFindinggrade B
melatoninSleep onset latencyOutcomeFindinggrade B
melatoninTotal leukocyte countOutcomeFindinggrade B
curcuminDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
curcuminAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade B
melatoninSleep onset latencyOutcomeFindinggrade B
curcuminHOMA-IROutcomeFindinggrade B
curcuminWithdrawal due to adverse eventsOutcomeFindinggrade B
curcuminVisual analogue scale pain intensityOutcomeFindinggrade B
melatoninTotal sleep timeOutcomeFindinggrade B
curcuminTotal antioxidant capacityOutcomeFindinggrade B
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade B
curcuminAlanine aminotransferaseOutcomeFindinggrade B
curcuminGlutathione peroxidase activityOutcomeFindinggrade B
coenzyme Q10Malondialdehyde (circulating)OutcomeFindinggrade B
resveratrolLDL cholesterolOutcomeFindinggrade B
curcuminMalondialdehyde (circulating)OutcomeFindinggrade B
curcuminFasting blood glucoseOutcomeFindinggrade B
melatoninTotal cholesterol (TC)OutcomeFindinggrade B
nitratePlasma nitrite concentrationOutcomeFindinggrade B
magnesium(2+)Metabolic syndrome (presence)OutcomeFindinggrade B
coenzyme Q10Blood haemoglobin concentrationOutcomeFindinggrade B
nitrateDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
curcuminGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
curcuminMalondialdehyde (circulating)OutcomeFindinggrade B
berberineHOMA-IROutcomeFindinggrade B
L-glutamineHospital length of stayOutcomeFindinggrade B
creatineFat massOutcomeFindinggrade B
coenzyme Q10Total leukocyte countOutcomeFindinggrade B
L-glutamineFasting blood glucoseOutcomeFindinggrade B
L-glutamineAll-cause mortalityOutcomeFindinggrade B
nitratePeak power outputOutcomeFindinggrade B
curcuminAspartate aminotransferaseOutcomeFindinggrade B
L-leucinePlasma glucagon-like peptide-1 (GLP-1)OutcomeFindinggrade B
nitratePlasma nitrite concentrationOutcomeFindinggrade B
luteinMacular pigment optical densityOutcomeFindinggrade B
luteinMacular pigment optical densityOutcomeFindinggrade B
L-arginineMaximal oxygen uptakeOutcomeFindinggrade B
L-arginineNecrotising enterocolitis incidenceOutcomeFindinggrade B
melatoninHDL cholesterolOutcomeFindinggrade B
resveratrolDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
curcuminSerum alkaline phosphataseOutcomeFindinggrade B
curcuminGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade B
caffeineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
caffeineLower-body muscular strength (pooled composite)OutcomeFindinggrade B
melatoninSerious adverse event incidenceOutcomeFindinggrade B
L-arginineInterleukin-6 concentrationOutcomeFindinggrade B
magnesium(2+)Metabolic syndrome (presence)OutcomeFindinggrade B
curcuminAlanine aminotransferaseOutcomeFindinggrade B
melatoninDuration of mechanical ventilationOutcomeFindinggrade B
coenzyme Q10Maximal oxygen uptakeOutcomeFindinggrade B
curcuminBody mass indexOutcomeFindinggrade B
all-cis-5,8,11,14,17-icosapentaenoic acidC-reactive protein concentrationOutcomeFindinggrade B
melatoninHOMA-IROutcomeFindinggrade B
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade B
creatineSerum creatinine concentrationOutcomeFindinggrade B
melatoninLDL cholesterolOutcomeFindinggrade B
resveratrolCatalase activityOutcomeFindinggrade B
curcuminDelayed-onset muscle sorenessOutcomeFindinggrade B
caffeineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
curcuminAspartate aminotransferaseOutcomeFindinggrade B
curcuminBody mass indexOutcomeFindinggrade B
coenzyme Q10HaematocritOutcomeFindinggrade B
curcuminC-reactive protein concentrationOutcomeFindinggrade B
melatoninMalondialdehyde (circulating)OutcomeFindinggrade B
curcuminAspartate aminotransferaseOutcomeFindinggrade B
curcuminTotal cholesterol (TC)OutcomeFindinggrade B
curcuminSerum creatinine concentrationOutcomeFindinggrade B
glucosamineWOMAC pain subscaleOutcomeFindinggrade B
melatoninIntensive care unit length of stayOutcomeFindinggrade B
melatoninAll-cause mortalityOutcomeFindinggrade B
L-glutamineInfectious complication rateOutcomeFindinggrade B
curcuminInterleukin-6 concentrationOutcomeFindinggrade B
magnesium(2+)C-reactive protein concentrationOutcomeFindinggrade B
curcuminMalondialdehyde (circulating)OutcomeFindinggrade B
curcuminLDL cholesterolOutcomeFindinggrade B
curcuminHDL cholesterolOutcomeFindinggrade B
curcuminTotal antioxidant capacityOutcomeFindinggrade B
curcuminTotal antioxidant capacityOutcomeFindinggrade B
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade B
astaxanthinMaximal oxygen uptakeOutcomeFindinggrade B
astaxanthinTime-trial completion timeOutcomeFindinggrade B
astaxanthinSystolic blood pressure (setting unspecified)OutcomeFindinggrade B
astaxanthinLDL cholesterolOutcomeFindinggrade B
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade B
CollagenStratum corneum hydration (corneometry)OutcomeFindinggrade B
riboflavinAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade B
curcuminSuperoxide dismutase activityOutcomeFindinggrade B
L-glutamineAll-cause mortalityOutcomeFindinggrade B
L-arginineTumour necrosis factor alpha concentrationOutcomeFindinggrade B
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade B
resveratrolFasting blood glucoseOutcomeFindinggrade B
caffeineTime to exhaustionOutcomeFindinggrade C
curcuminTriglyceridesOutcomeFindinggrade C
creatineInterleukin-6 concentrationOutcomeFindinggrade C
creatineEstimated glomerular filtration rateOutcomeFindinggrade C
melatoninSystolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninDiastolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninDiastolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninTotal sleep timeOutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
melatoninSystolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninDiastolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
resveratrolDiastolic blood pressure (office/clinic)OutcomeFindinggrade C
L-citrullineHOMA-IROutcomeFindinggrade C
L-citrullineFlow-mediated dilationOutcomeFindinggrade C
melatoninC-reactive protein concentrationOutcomeFindinggrade C
caffeineCountermovement jump heightOutcomeFindinggrade C
resveratrolGlutathione peroxidase activityOutcomeFindinggrade C
melatoninTotal sleep timeOutcomeFindinggrade C
berberineFasting blood glucoseOutcomeFindinggrade C
nitratePlasma nitrate concentrationOutcomeFindinggrade C
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade C
curcuminFasting blood glucoseOutcomeFindinggrade C
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade C
astaxanthinInterleukin-6 concentrationOutcomeFindinggrade C
titanium dioxideC-reactive protein concentrationOutcomeFindinggrade C
titanium dioxideTotal antioxidant capacityOutcomeFindinggrade C
titanium dioxideTumour necrosis factor alpha concentrationOutcomeFindinggrade C
glucosamineOsteoarthritis pain (pooled across scales)OutcomeFindinggrade D
(-)-epigallocatechin 3-gallateGlycated haemoglobin (HbA1c)OutcomeFindinggrade D
glucosamineRadiographic joint-space narrowingOutcomeFindinggrade D
glucosamineOsteoarthritis pain (pooled across scales)OutcomeFindinggrade D
magnesium(2+)Mean power outputOutcomeFindinggrade D
glucosaminePhysical function (pooled across scales)OutcomeFindinggrade D
coenzyme Q10HOMA-IROutcomeFindinggrade D
melatoninAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade D
methylene blueMean arterial pressure in vasodilatory shockOutcomeFindinggrade D
methylene blueSystemic vascular resistanceOutcomeFindinggrade D
coenzyme Q10Total cholesterol (TC)OutcomeFindinggrade D
methylene blueIncidence of postoperative deliriumOutcomeFindinggrade D
L-arginineBody mass indexOutcomeFindinggrade D
L-arginineBody massOutcomeFindinggrade D
coenzyme Q10TriglyceridesOutcomeFindinggrade D
resveratrolDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
coenzyme Q10Catalase activityOutcomeFindinggrade D
coenzyme Q10HDL cholesterolOutcomeFindinggrade D
(-)-epigallocatechin 3-gallateHOMA-IROutcomeFindinggrade D
resveratrolAlanine aminotransferaseOutcomeFindinggrade D
coenzyme Q10HOMA-IROutcomeFindinggrade D
L-citrullineRepeated-sprint performance decrementOutcomeFindinggrade D
coenzyme Q10Fasting blood glucoseOutcomeFindinggrade D
berberineAlanine aminotransferaseOutcomeFindinggrade D
resveratrolC-reactive protein concentrationOutcomeFindinggrade D
coenzyme Q10C-reactive protein concentrationOutcomeFindinggrade D
berberineAspartate aminotransferaseOutcomeFindinggrade D
coenzyme Q10Flow-mediated dilationOutcomeFindinggrade D
coenzyme Q10Reduced glutathione concentrationOutcomeFindinggrade D
magnesium(2+)Peak power outputOutcomeFindinggrade D
resveratrolSerum adiponectinOutcomeFindinggrade D
resveratrolGlutathione peroxidase activityOutcomeFindinggrade D
nitrateSix-minute walk test distanceOutcomeFindinggrade D
resveratrolSerum leptinOutcomeFindinggrade D
resveratrolHOMA-IROutcomeFindinggrade D
resveratrolHOMA-IROutcomeFindinggrade D
coenzyme Q10Fasting blood glucoseOutcomeFindinggrade D
L-arginineC-reactive protein concentrationOutcomeFindinggrade D
resveratrolSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
nitrateSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)Incidence of strokeOutcomeFindinggrade D
resveratrolDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
resveratrolFlow-mediated dilationOutcomeFindinggrade D
resveratrolFlow-mediated dilationOutcomeFindinggrade D
curcuminSerum alkaline phosphataseOutcomeFindinggrade D
L-isoleucinePostprandial blood glucose area under the curveOutcomeFindinggrade D
L-arginineArginine-to-ornithine ratioOutcomeFindinggrade D
resveratrolVisual analogue scale pain intensityOutcomeFindinggrade D
coenzyme Q10Serum creatinine concentrationOutcomeFindinggrade D
chondroitin sulfateRadiographic joint-space narrowingOutcomeFindinggrade D
L-isoleucinePeak postprandial blood glucoseOutcomeFindinggrade D
magnesium(2+)Maximal oxygen uptakeOutcomeFindinggrade D
magnesium(2+)LDL cholesterolOutcomeFindinggrade D
nitratePlasma nitrate concentrationOutcomeFindinggrade D
magnesium(2+)Cardiovascular mortalityOutcomeFindinggrade D
nitratePlasma nitrite concentrationOutcomeFindinggrade D
magnesium(2+)TriglyceridesOutcomeFindinggrade D
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade D
curcuminMalondialdehyde (circulating)OutcomeFindinggrade D
L-arginineC-reactive protein concentrationOutcomeFindinggrade D
L-arginineTumour necrosis factor alpha concentrationOutcomeFindinggrade D
magnesium(2+)Total cholesterol (TC)OutcomeFindinggrade D
L-arginineDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)HDL cholesterolOutcomeFindinggrade D
nitrateIsometric peak forceOutcomeFindinggrade D
creatineInterleukin-6 concentrationOutcomeFindinggrade D
resveratrolSerum uric acidOutcomeFindinggrade D
magnesium(2+)Flow-mediated dilationOutcomeFindinggrade D
L-arginineSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
creatineSerum creatine kinase activityOutcomeFindinggrade D
L-arginineGlycated haemoglobin (HbA1c)OutcomeFindinggrade D
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade D
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade D
creatineSerum creatinine concentrationOutcomeFindinggrade D
L-arginineInterleukin-6 concentrationOutcomeFindinggrade D
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade D
magnesium(2+)Time-trial completion timeOutcomeFindinggrade D
curcuminFasting blood glucoseOutcomeFindinggrade D
curcuminSerum adiponectinOutcomeFindinggrade D
melatoninAll-cause mortalityOutcomeFindinggrade D
nitratePlasma nitrite concentrationOutcomeFindinggrade D
creatineGlutathione peroxidase activityOutcomeFindinggrade D
melatoninAll-cause mortalityOutcomeFindinggrade D
curcuminSerum leptinOutcomeFindinggrade D
melatoninAll-cause mortalityOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
curcuminAlanine aminotransferaseOutcomeFindinggrade D
curcuminTriglyceridesOutcomeFindinggrade D
curcuminInterleukin-6 concentrationOutcomeFindinggrade D
L-arginineSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
L-arginineHOMA-IROutcomeFindinggrade D
magnesium(2+)Withdrawal due to adverse eventsOutcomeFindinggrade D
L-arginineDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)C-reactive protein concentrationOutcomeFindinggrade D
curcuminInterleukin-6 concentrationOutcomeFindinggrade D
CollagenPhysical function (pooled across scales)OutcomeFindinggrade D
resveratrolBody massOutcomeFindinggrade D
resveratrolInterleukin-6 concentrationOutcomeFindinggrade D
L-arginineTotal antioxidant capacityOutcomeFindinggrade D
(-)-epigallocatechin 3-gallateFasting blood glucoseOutcomeFindinggrade D
L-arginineInfectious complication rateOutcomeFindinggrade D
creatineIsometric peak forceOutcomeFindinggrade D
curcuminSerum alkaline phosphataseOutcomeFindinggrade D
berberineBody mass indexOutcomeFindinggrade D
creatineTumour necrosis factor alpha concentrationOutcomeFindinggrade D
magnesium(2+)All-cause mortalityOutcomeFindinggrade D
CollagenVisual analogue scale pain intensityOutcomeFindinggrade D
coenzyme Q10Anxiety symptom severity (pooled across unnamed instruments)OutcomeFindinggrade D
L-arginineLDL cholesterolOutcomeFindinggrade D
L-arginineTotal cholesterol (TC)OutcomeFindinggrade D
L-arginineHDL cholesterolOutcomeFindinggrade D
curcuminTotal antioxidant capacityOutcomeFindinggrade D
berberineC-reactive protein concentrationOutcomeFindinggrade D
nitrateMean arterial pressureOutcomeFindinggrade D
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade D
creatineMuscle strength (pooled across mixed instruments)OutcomeFindinggrade D
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade D
astaxanthinTotal testosteroneOutcomeFindinggrade D
astaxanthinC-reactive protein concentrationOutcomeFindinggrade D
astaxanthinTumour necrosis factor alpha concentrationOutcomeFindinggrade D
5-hydroxy-L-tryptophanFat massOutcomeFindinggrade D
aspartameTotal cholesterol (TC)OutcomeFindinggrade D
aspartameBody massOutcomeFindinggrade D
astaxanthinInterleukin-6 concentrationOutcomeFindinggrade D
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade D
berberineWaist-to-hip ratioOutcomeFindinggrade D
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade D
curcuminTotal cholesterol (TC)OutcomeFindinggrade D
coenzyme Q10Clinical attachment level (CAL) gainOutcomeFindinggrade D
curcuminBody massOutcomeFindinggrade D
caffeineBody massOutcomeFindinggrade D
caffeineBody mass indexOutcomeFindinggrade D
caffeineFat massOutcomeFindinggrade D
melatoninMini-Mental State Examination total scoreOutcomeFindinggrade D
melatoninAlanine aminotransferaseOutcomeFindinggrade D
magnesium(2+)Flow-mediated dilationOutcomeFindinggrade D
melatoninIncidence of postoperative deliriumOutcomeFindinggrade D
melatoninHDL cholesterolOutcomeFindinggrade D
curcuminHDL cholesterolOutcomeFindinggrade D
berberineHDL cholesterolOutcomeFindinggrade D
melatoninFasting blood glucoseOutcomeFindinggrade D
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade D
curcuminFlow-mediated dilationOutcomeFindinggrade D
resveratrolSerum leptinOutcomeFindinggrade D
curcuminFlow-mediated dilationOutcomeFindinggrade D
curcuminSerum adiponectinOutcomeFindinggrade D
resveratrolSerum adiponectinOutcomeFindinggrade D
resveratrolInterleukin-6 concentrationOutcomeFindinggrade D
resveratrolSubjective fatigueOutcomeFindinggrade D
magnesium(2+)Colorectal cancer incidenceOutcomeFindinggrade D
melatoninIncidence of ICU deliriumOutcomeFindinggrade D
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)HDL cholesterolOutcomeFindinggrade D
magnesium(2+)Total cholesterol (TC)OutcomeFindinggrade D
magnesium(2+)LDL cholesterolOutcomeFindinggrade D
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade D
curcuminSuperoxide dismutase activityOutcomeFindinggrade D
curcuminSerum leptinOutcomeFindinggrade D
L-glutamineInfectious complication rateOutcomeFindinggrade D
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade D
curcuminSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
curcuminTotal cholesterol (TC)OutcomeFindinggrade D
melatoninIntensive care unit length of stayOutcomeFindinggrade D
nitratePlasma nitrite concentrationOutcomeFindinggrade D
melatoninC-reactive protein concentrationOutcomeFindinggrade D
L-glutamineAll-cause mortalityOutcomeFindinggrade D
magnesium(2+)Lumbar spine bone mineral densityOutcomeFindinggrade D
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade D
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade D
curcuminTriglyceridesOutcomeFindinggrade D
curcuminHDL cholesterolOutcomeFindinggrade D
coenzyme Q10Clinical attachment level (CAL) gainOutcomeFindinggrade D
melatoninInterleukin-6 concentrationOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
melatoninIncidence of ICU deliriumOutcomeFindinggrade D
resveratrolSuperoxide dismutase activityOutcomeFindinggrade D
coenzyme Q10Malondialdehyde (circulating)OutcomeFindinggrade D
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade D
melatoninMuscle strength (pooled across mixed instruments)OutcomeFindinggrade D
curcuminMalondialdehyde (circulating)OutcomeFindinggrade D
resveratrolTotal antioxidant capacityOutcomeFindinggrade D
L-arginineTumour necrosis factor alpha concentrationOutcomeFindinggrade D
L-arginineFlow-mediated dilationOutcomeFindinggrade D
nitrateRating of perceived exertionOutcomeFindinggrade D
creatineIsometric peak forceOutcomeFindinggrade D
curcuminSuperoxide dismutase activityOutcomeFindinggrade D
melatoninCatalase activityOutcomeFindinggrade D
resveratrolGlycated haemoglobin (HbA1c)OutcomeFindinggrade D
resveratrolFasting blood glucoseOutcomeFindinggrade D
resveratrolSerum albuminOutcomeFindinggrade D
nitrateSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)Serum magnesium concentrationOutcomeFindinggrade D
caffeineRating of perceived exertionOutcomeFindinggrade D
caffeineCountermovement jump heightOutcomeFindinggrade D
caffeineSquat jump heightOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
caffeineNecrotising enterocolitis incidenceOutcomeFindinggrade D
resveratrolOrganism lifespanOutcomeFindinggrade F
(-)-epigallocatechin 3-gallateLean body massOutcomeFindinggrade F
curcuminInterleukin-6 concentrationOutcomeFindinggrade F
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade F
astaxanthinTNFRSF1BProteinFindinggrade F
5-hydroxy-L-tryptophanPlasma/serum 5-hydroxytryptophan concentrationOutcomeFindinggrade F
melatoninCYP1A2ProteinHypothesis
melatoninCYP1A1ProteinHypothesis
melatoninCYP1B1ProteinHypothesis
melatoninCYP2C19ProteinHypothesis
melatoninASMTProteinHypothesis
melatoninIDO1ProteinHypothesis
magnesium(2+)VDAC1ProteinHypothesis
magnesium(2+)SLC25A23ProteinHypothesis
magnesium(2+)SLC25A24ProteinHypothesis
magnesium(2+)PIEZO1ProteinHypothesis
magnesium(2+)SLC41A1ProteinHypothesis
magnesium(2+)GRIA1ProteinHypothesis
coenzyme Q10STARD7ProteinHypothesis
coenzyme Q10NQO1ProteinHypothesis
coenzyme Q10AIFM2ProteinHypothesis
coenzyme Q10SQORProteinHypothesis
L-arginineCTSBProteinHypothesis
L-arginineNOS2ProteinHypothesis
L-arginineCTSDProteinHypothesis
L-arginineCTSGProteinHypothesis
L-arginineCTSLProteinHypothesis
L-arginineSLC25A29ProteinHypothesis
creatineCKBProteinHypothesis
creatineSLC6A8ProteinHypothesis
creatineCKMT1AProteinHypothesis
creatineCKMProteinHypothesis
creatineGAMTProteinHypothesis
creatineCKMT2ProteinHypothesis
nitrateCLIC4ProteinHypothesis
nitrateCLIC1ProteinHypothesis
nitrateSLC1A5ProteinHypothesis
nitrateCLCC1ProteinHypothesis
nitrateSLC1A4ProteinHypothesis
nitrateSLC26A2ProteinHypothesis
L-glutamineSLC1A5ProteinHypothesis
L-glutamineSLC38A2ProteinHypothesis
L-glutamineCTSBProteinHypothesis
L-glutamineCTSDProteinHypothesis
L-glutamineCTSGProteinHypothesis
L-glutamineCTSLProteinHypothesis
calciolCYP27A1ProteinHypothesis
calciolCYP2R1ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidPTGS2ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP2C9ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP2C8ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidABCD3ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP2E1ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP1A1ProteinHypothesis
L-citrullineNOS2ProteinHypothesis
L-citrullineNOS3ProteinHypothesis
L-citrullineNOS1ProteinHypothesis
L-citrullineSLC7A9ProteinHypothesis
L-citrullineASS1ProteinHypothesis
L-citrullineOTCProteinHypothesis
luteinBCO2ProteinHypothesis
luteinRPE65ProteinHypothesis
L-isoleucineCTSBProteinHypothesis
L-isoleucineCTSDProteinHypothesis
L-isoleucineCTSGProteinHypothesis
L-isoleucineACE2ProteinHypothesis
L-isoleucineSLC7A5ProteinHypothesis
L-isoleucineCTSLProteinHypothesis
5-hydroxy-L-tryptophanTPH1ProteinHypothesis
5-hydroxy-L-tryptophanDDCProteinHypothesis
5-hydroxy-L-tryptophanTPH2ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidALOX5ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidCYP2E1ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidABCD3ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidPTGS2ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidFABP5ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidALOX15ProteinHypothesis
riboflavinRFKProteinHypothesis
riboflavinALPIProteinHypothesis
riboflavinBLVRBProteinHypothesis
riboflavinABCG2ProteinHypothesis
riboflavinACP3ProteinHypothesis
riboflavinSLC52A2ProteinHypothesis
L-leucineCTSBProteinHypothesis
L-leucineCTSDProteinHypothesis
L-leucineCTSGProteinHypothesis
L-leucineSLC38A2ProteinHypothesis
L-leucineCTSLProteinHypothesis
L-leucineSLC7A5ProteinHypothesis

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197 entities, 482 connections

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Every placement in the body is an inference: a compound is placed in a region because a transporter known to carry it is expressed in a tissue of that region, not because any source reports it arriving there. Filtering here filters by hypothesis.

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25,306 nodes · 3,213 compounds · 28 with a graded finding · 2,915 with a route · drawing 28 · hub metabolites excluded by the projection

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Distance from the middle is the layer, never the grade. What a graded finding touches is in the middle, what that reaches is around it, and the rest of the reference layer is outside that.
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Line weight and dash are the grade

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B · Likely
C · Suggestive
D · Preliminary
F · Speculative

A gap is a claim nobody made

Finding — a source reports it
Hypothesis — a path through a shared intermediate

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Entities

197

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Edge list

197 entities, 482 connections: 399 findings and 83 inferred.

Capped at 6 proteins per compound (238 omitted); hub metabolites excluded.

Inferred

Derived from Rhea, Reactome, UniProt, ChEBI and Gene Ontology. These are established reactions, but no source reports the connection being drawn from them, and nothing here carries a grade.

all-cis-5,8,11,14,17-icosapentaenoic acidHOMA-IROutcomeFindinggrade A
methylene blueAll-cause mortalityOutcomeFindinggrade A
methylene blueIntensive care unit length of stayOutcomeFindinggrade A
coenzyme Q10C-reactive protein concentrationOutcomeFindinggrade A
resveratrolHDL cholesterolOutcomeFindinggrade A
coenzyme Q10Erythrocyte sedimentation rateOutcomeFindinggrade A
coenzyme Q10Superoxide dismutase activityOutcomeFindinggrade A
all-cis-5,8,11,14,17-icosapentaenoic acidSerum albuminOutcomeFindinggrade A
resveratrolTotal cholesterol (TC)OutcomeFindinggrade A
resveratrolFat massOutcomeFindinggrade A
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade A
resveratrolClinical pregnancy rateOutcomeFindinggrade A

Show the remaining 470 connections

coenzyme Q10Intensive care unit length of stayOutcomeFindinggrade A
resveratrolHDL cholesterolOutcomeFindinggrade A
coenzyme Q10All-cause mortalityOutcomeFindinggrade A
resveratrolTriglyceridesOutcomeFindinggrade A
L-glutamineCD4/CD8 ratioOutcomeFindinggrade A
L-glutamineAll-cause mortalityOutcomeFindinggrade A
creatineCountermovement jump heightOutcomeFindinggrade A
methylene blueHospital length of stayOutcomeFindinggrade A
resveratrolTotal testosteroneOutcomeFindinggrade A
creatineLean body massOutcomeFindinggrade B
melatoninGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
creatineSerum creatinine concentrationOutcomeFindinggrade B
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade B
curcuminDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
melatoninBody mass indexOutcomeFindinggrade B
curcuminBody mass indexOutcomeFindinggrade B
all-cis-5,8,11,14,17-icosapentaenoic acidErythrocyte sedimentation rateOutcomeFindinggrade B
melatoninTotal antioxidant capacityOutcomeFindinggrade B
berberineTotal cholesterol (TC)OutcomeFindinggrade B
berberineAdverse reaction incidence (unstandardised)OutcomeFindinggrade B
caffeineTime-trial completion timeOutcomeFindinggrade B
nitrateColorectal cancer incidenceOutcomeFindinggrade B
creatineOne-repetition maximum strengthOutcomeFindinggrade B
creatineC-reactive protein concentrationOutcomeFindinggrade B
creatineSerum creatinine concentrationOutcomeFindinggrade B
creatineLower-body muscular strength (pooled composite)OutcomeFindinggrade B
curcuminSerum alkaline phosphataseOutcomeFindinggrade B
L-glutamineInfectious complication rateOutcomeFindinggrade B
nitrateMaximal oxygen uptakeOutcomeFindinggrade B
nitrateUrinary bladder cancer incidenceOutcomeFindinggrade B
nitrateMean power outputOutcomeFindinggrade B
nitratePlasma nitrate concentrationOutcomeFindinggrade B
creatineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
methylene blueDuration of mechanical ventilationOutcomeFindinggrade B
creatineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
L-glutamineC-reactive protein concentrationOutcomeFindinggrade B
caffeineLower-body muscular strength (pooled composite)OutcomeFindinggrade B
curcuminInterleukin-6 concentrationOutcomeFindinggrade B
luteinWorking memory performanceOutcomeFindinggrade B
L-arginineCD4+ T cell countOutcomeFindinggrade B
curcuminErythrocyte sedimentation rateOutcomeFindinggrade B
berberineGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
curcuminDisease Activity Score in 28 joints (DAS-28)OutcomeFindinggrade B
resveratrolC-reactive protein concentrationOutcomeFindinggrade B
nitrateBody mass indexOutcomeFindinggrade B
magnesium(2+)Serum magnesium concentrationOutcomeFindinggrade B
resveratrolMalondialdehyde (circulating)OutcomeFindinggrade B
methylene blueHospital length of stayOutcomeFindinggrade B
caffeineOne-repetition maximum strengthOutcomeFindinggrade B
curcuminSystolic blood pressure (setting unspecified)OutcomeFindinggrade B
L-glutamineGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
L-citrullineFlow-mediated dilationOutcomeFindinggrade B
magnesium(2+)Body mass indexOutcomeFindinggrade B
caffeineAdverse reaction incidence (unstandardised)OutcomeFindinggrade B
coenzyme Q10Fasting blood glucoseOutcomeFindinggrade B
coenzyme Q10Clinical pregnancy rateOutcomeFindinggrade B
melatoninFasting blood glucoseOutcomeFindinggrade B
melatoninMalondialdehyde (circulating)OutcomeFindinggrade B
melatoninTotal antioxidant capacityOutcomeFindinggrade B
caffeineRating of perceived exertionOutcomeFindinggrade B
melatoninSleep onset latencyOutcomeFindinggrade B
melatoninTotal leukocyte countOutcomeFindinggrade B
curcuminDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
curcuminAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade B
melatoninSleep onset latencyOutcomeFindinggrade B
curcuminHOMA-IROutcomeFindinggrade B
curcuminWithdrawal due to adverse eventsOutcomeFindinggrade B
curcuminVisual analogue scale pain intensityOutcomeFindinggrade B
melatoninTotal sleep timeOutcomeFindinggrade B
curcuminTotal antioxidant capacityOutcomeFindinggrade B
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade B
curcuminAlanine aminotransferaseOutcomeFindinggrade B
curcuminGlutathione peroxidase activityOutcomeFindinggrade B
coenzyme Q10Malondialdehyde (circulating)OutcomeFindinggrade B
resveratrolLDL cholesterolOutcomeFindinggrade B
curcuminMalondialdehyde (circulating)OutcomeFindinggrade B
curcuminFasting blood glucoseOutcomeFindinggrade B
melatoninTotal cholesterol (TC)OutcomeFindinggrade B
nitratePlasma nitrite concentrationOutcomeFindinggrade B
magnesium(2+)Metabolic syndrome (presence)OutcomeFindinggrade B
coenzyme Q10Blood haemoglobin concentrationOutcomeFindinggrade B
nitrateDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
curcuminGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
curcuminMalondialdehyde (circulating)OutcomeFindinggrade B
berberineHOMA-IROutcomeFindinggrade B
L-glutamineHospital length of stayOutcomeFindinggrade B
creatineFat massOutcomeFindinggrade B
coenzyme Q10Total leukocyte countOutcomeFindinggrade B
L-glutamineFasting blood glucoseOutcomeFindinggrade B
L-glutamineAll-cause mortalityOutcomeFindinggrade B
nitratePeak power outputOutcomeFindinggrade B
curcuminAspartate aminotransferaseOutcomeFindinggrade B
L-leucinePlasma glucagon-like peptide-1 (GLP-1)OutcomeFindinggrade B
nitratePlasma nitrite concentrationOutcomeFindinggrade B
luteinMacular pigment optical densityOutcomeFindinggrade B
luteinMacular pigment optical densityOutcomeFindinggrade B
L-arginineMaximal oxygen uptakeOutcomeFindinggrade B
L-arginineNecrotising enterocolitis incidenceOutcomeFindinggrade B
melatoninHDL cholesterolOutcomeFindinggrade B
resveratrolDiastolic blood pressure (setting unspecified)OutcomeFindinggrade B
curcuminSerum alkaline phosphataseOutcomeFindinggrade B
curcuminGlycated haemoglobin (HbA1c)OutcomeFindinggrade B
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade B
caffeineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
caffeineLower-body muscular strength (pooled composite)OutcomeFindinggrade B
melatoninSerious adverse event incidenceOutcomeFindinggrade B
L-arginineInterleukin-6 concentrationOutcomeFindinggrade B
magnesium(2+)Metabolic syndrome (presence)OutcomeFindinggrade B
curcuminAlanine aminotransferaseOutcomeFindinggrade B
melatoninDuration of mechanical ventilationOutcomeFindinggrade B
coenzyme Q10Maximal oxygen uptakeOutcomeFindinggrade B
curcuminBody mass indexOutcomeFindinggrade B
all-cis-5,8,11,14,17-icosapentaenoic acidC-reactive protein concentrationOutcomeFindinggrade B
melatoninHOMA-IROutcomeFindinggrade B
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade B
creatineSerum creatinine concentrationOutcomeFindinggrade B
melatoninLDL cholesterolOutcomeFindinggrade B
resveratrolCatalase activityOutcomeFindinggrade B
curcuminDelayed-onset muscle sorenessOutcomeFindinggrade B
caffeineUpper-body muscular strength (pooled composite)OutcomeFindinggrade B
curcuminAspartate aminotransferaseOutcomeFindinggrade B
curcuminBody mass indexOutcomeFindinggrade B
coenzyme Q10HaematocritOutcomeFindinggrade B
curcuminC-reactive protein concentrationOutcomeFindinggrade B
melatoninMalondialdehyde (circulating)OutcomeFindinggrade B
curcuminAspartate aminotransferaseOutcomeFindinggrade B
curcuminTotal cholesterol (TC)OutcomeFindinggrade B
curcuminSerum creatinine concentrationOutcomeFindinggrade B
glucosamineWOMAC pain subscaleOutcomeFindinggrade B
melatoninIntensive care unit length of stayOutcomeFindinggrade B
melatoninAll-cause mortalityOutcomeFindinggrade B
L-glutamineInfectious complication rateOutcomeFindinggrade B
curcuminInterleukin-6 concentrationOutcomeFindinggrade B
magnesium(2+)C-reactive protein concentrationOutcomeFindinggrade B
curcuminMalondialdehyde (circulating)OutcomeFindinggrade B
curcuminLDL cholesterolOutcomeFindinggrade B
curcuminHDL cholesterolOutcomeFindinggrade B
curcuminTotal antioxidant capacityOutcomeFindinggrade B
curcuminTotal antioxidant capacityOutcomeFindinggrade B
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade B
astaxanthinMaximal oxygen uptakeOutcomeFindinggrade B
astaxanthinTime-trial completion timeOutcomeFindinggrade B
astaxanthinSystolic blood pressure (setting unspecified)OutcomeFindinggrade B
astaxanthinLDL cholesterolOutcomeFindinggrade B
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade B
CollagenStratum corneum hydration (corneometry)OutcomeFindinggrade B
riboflavinAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade B
curcuminSuperoxide dismutase activityOutcomeFindinggrade B
L-glutamineAll-cause mortalityOutcomeFindinggrade B
L-arginineTumour necrosis factor alpha concentrationOutcomeFindinggrade B
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade B
resveratrolFasting blood glucoseOutcomeFindinggrade B
caffeineTime to exhaustionOutcomeFindinggrade C
curcuminTriglyceridesOutcomeFindinggrade C
creatineInterleukin-6 concentrationOutcomeFindinggrade C
creatineEstimated glomerular filtration rateOutcomeFindinggrade C
melatoninSystolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninDiastolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninDiastolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninTotal sleep timeOutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
melatoninSystolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninDiastolic blood pressure (setting unspecified)OutcomeFindinggrade C
melatoninMean arterial pressureOutcomeFindinggrade C
resveratrolDiastolic blood pressure (office/clinic)OutcomeFindinggrade C
L-citrullineHOMA-IROutcomeFindinggrade C
L-citrullineFlow-mediated dilationOutcomeFindinggrade C
melatoninC-reactive protein concentrationOutcomeFindinggrade C
caffeineCountermovement jump heightOutcomeFindinggrade C
resveratrolGlutathione peroxidase activityOutcomeFindinggrade C
melatoninTotal sleep timeOutcomeFindinggrade C
berberineFasting blood glucoseOutcomeFindinggrade C
nitratePlasma nitrate concentrationOutcomeFindinggrade C
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade C
curcuminFasting blood glucoseOutcomeFindinggrade C
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade C
astaxanthinInterleukin-6 concentrationOutcomeFindinggrade C
titanium dioxideC-reactive protein concentrationOutcomeFindinggrade C
titanium dioxideTotal antioxidant capacityOutcomeFindinggrade C
titanium dioxideTumour necrosis factor alpha concentrationOutcomeFindinggrade C
glucosamineOsteoarthritis pain (pooled across scales)OutcomeFindinggrade D
(-)-epigallocatechin 3-gallateGlycated haemoglobin (HbA1c)OutcomeFindinggrade D
glucosamineRadiographic joint-space narrowingOutcomeFindinggrade D
glucosamineOsteoarthritis pain (pooled across scales)OutcomeFindinggrade D
magnesium(2+)Mean power outputOutcomeFindinggrade D
glucosaminePhysical function (pooled across scales)OutcomeFindinggrade D
coenzyme Q10HOMA-IROutcomeFindinggrade D
melatoninAdverse event occurrence (oral or enteral supplement)OutcomeFindinggrade D
methylene blueMean arterial pressure in vasodilatory shockOutcomeFindinggrade D
methylene blueSystemic vascular resistanceOutcomeFindinggrade D
coenzyme Q10Total cholesterol (TC)OutcomeFindinggrade D
methylene blueIncidence of postoperative deliriumOutcomeFindinggrade D
L-arginineBody mass indexOutcomeFindinggrade D
L-arginineBody massOutcomeFindinggrade D
coenzyme Q10TriglyceridesOutcomeFindinggrade D
resveratrolDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
coenzyme Q10Catalase activityOutcomeFindinggrade D
coenzyme Q10HDL cholesterolOutcomeFindinggrade D
(-)-epigallocatechin 3-gallateHOMA-IROutcomeFindinggrade D
resveratrolAlanine aminotransferaseOutcomeFindinggrade D
coenzyme Q10HOMA-IROutcomeFindinggrade D
L-citrullineRepeated-sprint performance decrementOutcomeFindinggrade D
coenzyme Q10Fasting blood glucoseOutcomeFindinggrade D
berberineAlanine aminotransferaseOutcomeFindinggrade D
resveratrolC-reactive protein concentrationOutcomeFindinggrade D
coenzyme Q10C-reactive protein concentrationOutcomeFindinggrade D
berberineAspartate aminotransferaseOutcomeFindinggrade D
coenzyme Q10Flow-mediated dilationOutcomeFindinggrade D
coenzyme Q10Reduced glutathione concentrationOutcomeFindinggrade D
magnesium(2+)Peak power outputOutcomeFindinggrade D
resveratrolSerum adiponectinOutcomeFindinggrade D
resveratrolGlutathione peroxidase activityOutcomeFindinggrade D
nitrateSix-minute walk test distanceOutcomeFindinggrade D
resveratrolSerum leptinOutcomeFindinggrade D
resveratrolHOMA-IROutcomeFindinggrade D
resveratrolHOMA-IROutcomeFindinggrade D
coenzyme Q10Fasting blood glucoseOutcomeFindinggrade D
L-arginineC-reactive protein concentrationOutcomeFindinggrade D
resveratrolSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
nitrateSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)Incidence of strokeOutcomeFindinggrade D
resveratrolDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
resveratrolFlow-mediated dilationOutcomeFindinggrade D
resveratrolFlow-mediated dilationOutcomeFindinggrade D
curcuminSerum alkaline phosphataseOutcomeFindinggrade D
L-isoleucinePostprandial blood glucose area under the curveOutcomeFindinggrade D
L-arginineArginine-to-ornithine ratioOutcomeFindinggrade D
resveratrolVisual analogue scale pain intensityOutcomeFindinggrade D
coenzyme Q10Serum creatinine concentrationOutcomeFindinggrade D
chondroitin sulfateRadiographic joint-space narrowingOutcomeFindinggrade D
L-isoleucinePeak postprandial blood glucoseOutcomeFindinggrade D
magnesium(2+)Maximal oxygen uptakeOutcomeFindinggrade D
magnesium(2+)LDL cholesterolOutcomeFindinggrade D
nitratePlasma nitrate concentrationOutcomeFindinggrade D
magnesium(2+)Cardiovascular mortalityOutcomeFindinggrade D
nitratePlasma nitrite concentrationOutcomeFindinggrade D
magnesium(2+)TriglyceridesOutcomeFindinggrade D
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade D
curcuminMalondialdehyde (circulating)OutcomeFindinggrade D
L-arginineC-reactive protein concentrationOutcomeFindinggrade D
L-arginineTumour necrosis factor alpha concentrationOutcomeFindinggrade D
magnesium(2+)Total cholesterol (TC)OutcomeFindinggrade D
L-arginineDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)HDL cholesterolOutcomeFindinggrade D
nitrateIsometric peak forceOutcomeFindinggrade D
creatineInterleukin-6 concentrationOutcomeFindinggrade D
resveratrolSerum uric acidOutcomeFindinggrade D
magnesium(2+)Flow-mediated dilationOutcomeFindinggrade D
L-arginineSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
creatineSerum creatine kinase activityOutcomeFindinggrade D
L-arginineGlycated haemoglobin (HbA1c)OutcomeFindinggrade D
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade D
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade D
creatineSerum creatinine concentrationOutcomeFindinggrade D
L-arginineInterleukin-6 concentrationOutcomeFindinggrade D
calciolSerum 25-hydroxyvitamin D concentrationOutcomeFindinggrade D
magnesium(2+)Time-trial completion timeOutcomeFindinggrade D
curcuminFasting blood glucoseOutcomeFindinggrade D
curcuminSerum adiponectinOutcomeFindinggrade D
melatoninAll-cause mortalityOutcomeFindinggrade D
nitratePlasma nitrite concentrationOutcomeFindinggrade D
creatineGlutathione peroxidase activityOutcomeFindinggrade D
melatoninAll-cause mortalityOutcomeFindinggrade D
curcuminSerum leptinOutcomeFindinggrade D
melatoninAll-cause mortalityOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
curcuminAlanine aminotransferaseOutcomeFindinggrade D
curcuminTriglyceridesOutcomeFindinggrade D
curcuminInterleukin-6 concentrationOutcomeFindinggrade D
L-arginineSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
L-arginineHOMA-IROutcomeFindinggrade D
magnesium(2+)Withdrawal due to adverse eventsOutcomeFindinggrade D
L-arginineDiastolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)C-reactive protein concentrationOutcomeFindinggrade D
curcuminInterleukin-6 concentrationOutcomeFindinggrade D
CollagenPhysical function (pooled across scales)OutcomeFindinggrade D
resveratrolBody massOutcomeFindinggrade D
resveratrolInterleukin-6 concentrationOutcomeFindinggrade D
L-arginineTotal antioxidant capacityOutcomeFindinggrade D
(-)-epigallocatechin 3-gallateFasting blood glucoseOutcomeFindinggrade D
L-arginineInfectious complication rateOutcomeFindinggrade D
creatineIsometric peak forceOutcomeFindinggrade D
curcuminSerum alkaline phosphataseOutcomeFindinggrade D
berberineBody mass indexOutcomeFindinggrade D
creatineTumour necrosis factor alpha concentrationOutcomeFindinggrade D
magnesium(2+)All-cause mortalityOutcomeFindinggrade D
CollagenVisual analogue scale pain intensityOutcomeFindinggrade D
coenzyme Q10Anxiety symptom severity (pooled across unnamed instruments)OutcomeFindinggrade D
L-arginineLDL cholesterolOutcomeFindinggrade D
L-arginineTotal cholesterol (TC)OutcomeFindinggrade D
L-arginineHDL cholesterolOutcomeFindinggrade D
curcuminTotal antioxidant capacityOutcomeFindinggrade D
berberineC-reactive protein concentrationOutcomeFindinggrade D
nitrateMean arterial pressureOutcomeFindinggrade D
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade D
creatineMuscle strength (pooled across mixed instruments)OutcomeFindinggrade D
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade D
astaxanthinTotal testosteroneOutcomeFindinggrade D
astaxanthinC-reactive protein concentrationOutcomeFindinggrade D
astaxanthinTumour necrosis factor alpha concentrationOutcomeFindinggrade D
5-hydroxy-L-tryptophanFat massOutcomeFindinggrade D
aspartameTotal cholesterol (TC)OutcomeFindinggrade D
aspartameBody massOutcomeFindinggrade D
astaxanthinInterleukin-6 concentrationOutcomeFindinggrade D
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade D
berberineWaist-to-hip ratioOutcomeFindinggrade D
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade D
curcuminTotal cholesterol (TC)OutcomeFindinggrade D
coenzyme Q10Clinical attachment level (CAL) gainOutcomeFindinggrade D
curcuminBody massOutcomeFindinggrade D
caffeineBody massOutcomeFindinggrade D
caffeineBody mass indexOutcomeFindinggrade D
caffeineFat massOutcomeFindinggrade D
melatoninMini-Mental State Examination total scoreOutcomeFindinggrade D
melatoninAlanine aminotransferaseOutcomeFindinggrade D
magnesium(2+)Flow-mediated dilationOutcomeFindinggrade D
melatoninIncidence of postoperative deliriumOutcomeFindinggrade D
melatoninHDL cholesterolOutcomeFindinggrade D
curcuminHDL cholesterolOutcomeFindinggrade D
berberineHDL cholesterolOutcomeFindinggrade D
melatoninFasting blood glucoseOutcomeFindinggrade D
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade D
curcuminFlow-mediated dilationOutcomeFindinggrade D
resveratrolSerum leptinOutcomeFindinggrade D
curcuminFlow-mediated dilationOutcomeFindinggrade D
curcuminSerum adiponectinOutcomeFindinggrade D
resveratrolSerum adiponectinOutcomeFindinggrade D
resveratrolInterleukin-6 concentrationOutcomeFindinggrade D
resveratrolSubjective fatigueOutcomeFindinggrade D
magnesium(2+)Colorectal cancer incidenceOutcomeFindinggrade D
melatoninIncidence of ICU deliriumOutcomeFindinggrade D
magnesium(2+)Systolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)HDL cholesterolOutcomeFindinggrade D
magnesium(2+)Total cholesterol (TC)OutcomeFindinggrade D
magnesium(2+)LDL cholesterolOutcomeFindinggrade D
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade D
curcuminSuperoxide dismutase activityOutcomeFindinggrade D
curcuminSerum leptinOutcomeFindinggrade D
L-glutamineInfectious complication rateOutcomeFindinggrade D
magnesium(2+)Diastolic blood pressure (setting unspecified)OutcomeFindinggrade D
curcuminSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
curcuminTotal cholesterol (TC)OutcomeFindinggrade D
melatoninIntensive care unit length of stayOutcomeFindinggrade D
nitratePlasma nitrite concentrationOutcomeFindinggrade D
melatoninC-reactive protein concentrationOutcomeFindinggrade D
L-glutamineAll-cause mortalityOutcomeFindinggrade D
magnesium(2+)Lumbar spine bone mineral densityOutcomeFindinggrade D
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade D
magnesium(2+)Fasting blood glucoseOutcomeFindinggrade D
curcuminTriglyceridesOutcomeFindinggrade D
curcuminHDL cholesterolOutcomeFindinggrade D
coenzyme Q10Clinical attachment level (CAL) gainOutcomeFindinggrade D
melatoninInterleukin-6 concentrationOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
melatoninIncidence of ICU deliriumOutcomeFindinggrade D
resveratrolSuperoxide dismutase activityOutcomeFindinggrade D
coenzyme Q10Malondialdehyde (circulating)OutcomeFindinggrade D
coenzyme Q10Total antioxidant capacityOutcomeFindinggrade D
melatoninMuscle strength (pooled across mixed instruments)OutcomeFindinggrade D
curcuminMalondialdehyde (circulating)OutcomeFindinggrade D
resveratrolTotal antioxidant capacityOutcomeFindinggrade D
L-arginineTumour necrosis factor alpha concentrationOutcomeFindinggrade D
L-arginineFlow-mediated dilationOutcomeFindinggrade D
nitrateRating of perceived exertionOutcomeFindinggrade D
creatineIsometric peak forceOutcomeFindinggrade D
curcuminSuperoxide dismutase activityOutcomeFindinggrade D
melatoninCatalase activityOutcomeFindinggrade D
resveratrolGlycated haemoglobin (HbA1c)OutcomeFindinggrade D
resveratrolFasting blood glucoseOutcomeFindinggrade D
resveratrolSerum albuminOutcomeFindinggrade D
nitrateSystolic blood pressure (setting unspecified)OutcomeFindinggrade D
magnesium(2+)Serum magnesium concentrationOutcomeFindinggrade D
caffeineRating of perceived exertionOutcomeFindinggrade D
caffeineCountermovement jump heightOutcomeFindinggrade D
caffeineSquat jump heightOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
melatoninSleep onset latencyOutcomeFindinggrade D
caffeineNecrotising enterocolitis incidenceOutcomeFindinggrade D
resveratrolOrganism lifespanOutcomeFindinggrade F
(-)-epigallocatechin 3-gallateLean body massOutcomeFindinggrade F
curcuminInterleukin-6 concentrationOutcomeFindinggrade F
curcuminTumour necrosis factor alpha concentrationOutcomeFindinggrade F
astaxanthinTNFRSF1BProteinFindinggrade F
5-hydroxy-L-tryptophanPlasma/serum 5-hydroxytryptophan concentrationOutcomeFindinggrade F
melatoninCYP1A2ProteinHypothesis
melatoninCYP1A1ProteinHypothesis
melatoninCYP1B1ProteinHypothesis
melatoninCYP2C19ProteinHypothesis
melatoninASMTProteinHypothesis
melatoninIDO1ProteinHypothesis
magnesium(2+)VDAC1ProteinHypothesis
magnesium(2+)SLC25A23ProteinHypothesis
magnesium(2+)SLC25A24ProteinHypothesis
magnesium(2+)PIEZO1ProteinHypothesis
magnesium(2+)SLC41A1ProteinHypothesis
magnesium(2+)GRIA1ProteinHypothesis
coenzyme Q10STARD7ProteinHypothesis
coenzyme Q10NQO1ProteinHypothesis
coenzyme Q10AIFM2ProteinHypothesis
coenzyme Q10SQORProteinHypothesis
L-arginineCTSBProteinHypothesis
L-arginineNOS2ProteinHypothesis
L-arginineCTSDProteinHypothesis
L-arginineCTSGProteinHypothesis
L-arginineCTSLProteinHypothesis
L-arginineSLC25A29ProteinHypothesis
creatineCKBProteinHypothesis
creatineSLC6A8ProteinHypothesis
creatineCKMT1AProteinHypothesis
creatineCKMProteinHypothesis
creatineGAMTProteinHypothesis
creatineCKMT2ProteinHypothesis
nitrateCLIC4ProteinHypothesis
nitrateCLIC1ProteinHypothesis
nitrateSLC1A5ProteinHypothesis
nitrateCLCC1ProteinHypothesis
nitrateSLC1A4ProteinHypothesis
nitrateSLC26A2ProteinHypothesis
L-glutamineSLC1A5ProteinHypothesis
L-glutamineSLC38A2ProteinHypothesis
L-glutamineCTSBProteinHypothesis
L-glutamineCTSDProteinHypothesis
L-glutamineCTSGProteinHypothesis
L-glutamineCTSLProteinHypothesis
calciolCYP27A1ProteinHypothesis
calciolCYP2R1ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidPTGS2ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP2C9ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP2C8ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidABCD3ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP2E1ProteinHypothesis
all-cis-5,8,11,14,17-icosapentaenoic acidCYP1A1ProteinHypothesis
L-citrullineNOS2ProteinHypothesis
L-citrullineNOS3ProteinHypothesis
L-citrullineNOS1ProteinHypothesis
L-citrullineSLC7A9ProteinHypothesis
L-citrullineASS1ProteinHypothesis
L-citrullineOTCProteinHypothesis
luteinBCO2ProteinHypothesis
luteinRPE65ProteinHypothesis
L-isoleucineCTSBProteinHypothesis
L-isoleucineCTSDProteinHypothesis
L-isoleucineCTSGProteinHypothesis
L-isoleucineACE2ProteinHypothesis
L-isoleucineSLC7A5ProteinHypothesis
L-isoleucineCTSLProteinHypothesis
5-hydroxy-L-tryptophanTPH1ProteinHypothesis
5-hydroxy-L-tryptophanDDCProteinHypothesis
5-hydroxy-L-tryptophanTPH2ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidALOX5ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidCYP2E1ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidABCD3ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidPTGS2ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidFABP5ProteinHypothesis
all-cis-docosa-4,7,10,13,16,19-hexaenoic acidALOX15ProteinHypothesis
riboflavinRFKProteinHypothesis
riboflavinALPIProteinHypothesis
riboflavinBLVRBProteinHypothesis
riboflavinABCG2ProteinHypothesis
riboflavinACP3ProteinHypothesis
riboflavinSLC52A2ProteinHypothesis
L-leucineCTSBProteinHypothesis
L-leucineCTSDProteinHypothesis
L-leucineCTSGProteinHypothesis
L-leucineSLC38A2ProteinHypothesis
L-leucineCTSLProteinHypothesis
L-leucineSLC7A5ProteinHypothesis